| Identification |
|---|
| HMDB Protein ID
| CDBP02658 |
| Secondary Accession Numbers
| Not Available |
| Name
| Anoctamin-5 |
| Description
| Not Available |
| Synonyms
|
- Gnathodiaphyseal dysplasia 1 protein
- Transmembrane protein 16E
|
| Gene Name
| ANO5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| May act as a calcium-activated chloride channel |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p14.3 |
| SNPs
| ANO5 |
| Gene Sequence
|
>2742 bp
ATGGGCGACCCGGATCTCCTGGAAGTGTTGGCGGAGGAAGGGGAAAAAGTCAATAAGCAT
ATAGACTACTCTTTCCAAATGAGTGAGCAGAGCCTGAGCAGCAGAGAGACCAGCTTTCTC
ATCAATGAAGAAACAATGCCTGCAAAGCGATTCAATTTGTTCCTGAGGCGGCGGCTTATG
TTTCAAAAAAATCAGCAAAGCAAAGATTCTATCTTCTTCCGAGATGGGATTAGGCAAATT
GATTTTGTGCTTTCCTACGTTGATGACGTAAAGAAAGACGCAGAGTTAAAGGCGGAAAGA
AGAAAAGAGTTTGAAACTAATCTCAGAAAAACAGGTCTTGAGTTGGAAATAGAAGACAAA
AGGGACTCGGAAGATGGAAGAACTTATTTTGTCAAGATCCATGCCCCTTGGGAGGTATTA
GTTACCTATGCTGAAGTCTTGGGAATCAAAATGCCTATTAAGGAGAGTGATATTCCCCGC
CCTAAGCACACTCCTATAAGCTATGTGCTTGGACCTGTAAGACTCCCACTGAGTGTGAAG
TATCCCCATCCTGAATATTTTACTGCACAATTCAGCAGACATCGGCAGGAGCTCTTCCTC
ATCGAAGATCAGGCAACCTTCTTTCCATCCTCATCAAGAAACAGAATTGTGTACTATATT
CTCTCAAGATGTCCTTTTGGCATAGAAGATGGGAAGAAAAGGTTTGGGATTGAAAGACTG
CTAAACTCTAACACTTACTCATCTGCCTATCCACTCCATGATGGCCAATATTGGAAGCCA
TCAGAACCTCCCAATCCTACCAATGAAAGATACACACTTCACCAGAATTGGGCTCGATTT
TCCTATTTCTACAAGGAGCAGCCTTTAGACTTGATTAAGAATTATTATGGAGAAAAAATT
GGTATCTATTTTGTCTTTCTTGGATTTTACACAGAAATGCTATTCTTTGCAGCTGTAGTT
GGCTTAGCTTGTTTTATTTATGGCTTATTATCAATGGAACATAACACAAGCAGCACTGAA
ATCTGTGACCCTGAGATTGGTGGTCAGATGATCATGTGCCCACTCTGTGATCAAGTGTGT
GATTATTGGAGACTAAATAGTACGTGTTTGGCTTCAAAGTTCTCCCATTTGTTTGATAAT
GAGTCAACAGTGTTCTTTGCAATATTCATGGGAATTTGGGTCACCTTATTTTTGGAGTTT
TGGAAACAACGACAAGCCAGACTGGAATATGAATGGGACCTGGTGGACTTTGAAGAGGAA
CAGCAGCAGCTTCAGCTGAGACCAGAATTTGAAGCTATGTGTAAACACAGGAAATTGAAT
GCAGTGACTAAGGAGATGGAACCTTACATGCCTCTATACACGCGTATTCCATGGTACTTT
CTTTCAGGAGCCACAGTGACATTATGGATGTCTCTTGTCGTCACCAGTATGGTAGCTGTA
ATTGTGTACCGCCTGTCAGTCTTTGCTACATTTGCTAGTTTCATGGAAAGTGATGCATCC
TTAAAGCAGGTCAAAAGCTTCCTTACTCCTCAGATAACCACATCACTCACAGGATCATGC
TTGAACTTTATTGTCATCTTGATCTTGAATTTCTTTTATGAAAAGATATCTGCCTGGATC
ACAAAAATGGAAATTCCTCGAACATACCAGGAGTATGAGAGCAGTCTTACCTTGAAAATG
TTCCTGTTTCAGTTTGTAAATTTTTACTCATCCTGCTTCTACGTAGCTTTCTTTAAAGGG
AAGTTCGTAGGCTATCCTGGAAAATACACATATTTATTTAATGAGTGGAGAAGTGAAGAG
TGTGATCCTGGAGGCTGTCTTATAGAATTGACAACCCAATTGACCATTATAATGACCGGG
AAACAGATTTTTGGAAACATTAAAGAAGCCATTTATCCCTTGGCTTTGAATTGGTGGAGA
CGCCGAAAAGCTCGGACAAACTCTGAGAAGCTGTATAGTCGATGGGAGCAGGATCATGAC
CTTGAAAGTTTTGGACCCCTTGGGCTTTTCTATGAGTACTTAGAAACAGTTACTCAATTT
GGATTTGTTACACTATTTGTGGCCTCTTTTCCTTTGGCTCCTCTTCTTGCTCTCATAAAT
AATATTGTAGAGATTCGAGTGGATGCCTGGAAACTTACCACTCAATACAGGAGAACTGTA
GCTTCTAAAGCTCATAGCATAGGTGTTTGGCAAGACATTCTTTATGGAATGGCTGTCCTT
TCTGTTGCAACTAATGCCTTTATTGTTGCATTTACGTCAGACATCATTCCCCGTCTAGTT
TACTACTATGCTTACTCAACAAATGCCACACAGCCTATGACAGGATATGTGAATAATAGC
CTGTCAGTATTCCTGATAGCTGATTTTCCAAACCACACTGCACCTTCGGAAAAACGAGAC
TTCATCACTTGCAGGTACAGAGATTACAGATATCCTCCTGATGACGAGAATAAATATTTT
CATAATATGCAATTCTGGCATGTCCTTGCTGCCAAGATGACCTTCATCATTGTTATGGAA
CATGTTGTGTTTTTAGTTAAATTTTTGCTGGCCTGGATGATACCTGATGTTCCAAAAGAT
GTTGTGGAGAGAATCAAGAGAGAAAAGTTAATGACTATCAAGATTCTCCATGATTTTGAG
CTCAACAAATTAAAAGAGAACTTGGGAATTAATTCTAATGAATTTGCCAAGCATGTCATG
ATTGAGGAAAACAAAGCACAGCTGGCTAAATCAACACTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 913 |
| Molecular Weight
| 107186.7 |
| Theoretical pI
| 6.79 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["300-320", "381-401", "463-483", "512-532", "558-578", "680-700", "733-753", "835-855"]
|
| Protein Sequence
|
>Anoctamin-5
MGDPDLLEVLAEEGEKVNKHIDYSFQMSEQSLSSRETSFLINEETMPAKRFNLFLRRRLM
FQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDAELKAERRKEFETNLRKTGLELEIEDK
RDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHTPISYVLGPVRLPLSVK
YPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGIEDGKKRFGIERL
LNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLIKNYYGEKI
GIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPLCDQVC
DYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEE
QQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTRIPWYFLSGATVTLWMSLVVTSMVAV
IVYRLSVFATFASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYEKISAWI
TKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSEE
CDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNSEKLYSRWEQDHD
LESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTV
ASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYVNNS
LSVFLIADFPNHTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFIIVME
HVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHDFELNKLKENLGINSNEFAKHVM
IEENKAQLAKSTL
|
| External Links |
|---|
| GenBank ID Protein
| 46849562 |
| UniProtKB/Swiss-Prot ID
| Q75V66 |
| UniProtKB/Swiss-Prot Entry Name
| ANO5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB125267 |
| GeneCard ID
| ANO5 |
| GenAtlas ID
| ANO5 |
| HGNC ID
| HGNC:27337 |
| References |
|---|
| General References
| Not Available |