Identification |
HMDB Protein ID
| CDBP02655 |
Secondary Accession Numbers
| Not Available |
Name
| Anoctamin-2 |
Description
| Not Available |
Synonyms
|
- Transmembrane protein 16B
|
Gene Name
| ANO2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in intracellular calcium activated chloride ch |
Specific Function
| Acts as a calcium-activated chloride channel (CaCC), mostly in photoreceptors. May mediate olfactory amplification in olfactory sensory neurons (OSNs) and light perception amplification in retina |
GO Classification
|
Not Available
|
Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 12p13.3 |
SNPs
| ANO2 |
Gene Sequence
|
>3012 bp
ATGGCGACTCCCGGGCCGCGCGATATACCCCTGCTCCCTGGCTCCCCACGCCGGCTGAGC
CCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG
CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGC
GGTGGAGAGAGCACCCGCAGCAGCTCTGTCATCAACAACTATCTGGATGCCAATGAGCCT
GTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC
TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGC
CACTCGCTGGCTATCGTCTCCAATGGGGAGACAGGCAAGGAGCCTCATGCTGGGGGCCCA
GGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG
GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAA
AGCCAGGGATCCATCTTTGTCCGGATACACGCCCCGTGGCAGGTGCTGGCCAGAGAGGCA
GAATTCTTGAAGATCAAAGTTCCTACCAAGAAAGAGATGTACGAGATCAAAGCAGGAGGC
AGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGA
GTTCCAGAACACAGCAACAACAAGATGAAAAACCTCTCCTACCCATTCTCCAGGGAGAAG
ATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGTAGCCGC
ATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGGTATT
AACTCTCTGATCGCAAACAATATCTATGAGGCTGCCTACCCTCTTCATGACGGTGAATAC
GATAGTCCAGAGGACGATATGAATGACAGGAAGCTGCTATATCAAGAATGGGCGCGCTAT
GGAGTGTTCTATAAGTTCCAACCTATTGACCTCATCAGAAAGTATTTTGGAGAAAAAATT
GGACTGTATTTTGCCTGGCTGGGATTATATACATCATTCCTCATCCCATCTTCTGTAATT
GGAGTGATTGTGTTTCTTTATGGATGTGCAACAATTGAAGAAGATATTCCCAGCAGAGAG
ATGTGTGACCAGCAGAATGCCTTCACCATGTGTCCCCTGTGTGACAAGTCCTGTGATTAC
TGGAACCTCAGCTCAGCCTGTGGGACCGCGCAGGCCAGCCACCTGTTTGACAACCCTGCC
ACCGTCTTCTTCTCTATCTTCATGGCTCTGTGGGCTACCATGTTCCTGGAAAACTGGAAG
AGGCTACAGATGCGACTGGGCTACTTTTGGGACCTGACTGGCATAGAAGAGGAAGAAGAA
CGTGCCCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAG
GAGAGCAACCAGTCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAG
GATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGTTACCTGATGAACTTTGCC
TCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGA
ATAACAACTGCAGCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACA
GTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTCATCCTGGACGAGATCTAC
GGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAA
GAGCGCCTGATCCTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTC
TATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGAAGCTACGTCTATGTATTC
GATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAG
CTCAGCATCATCATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTC
CCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACCGAAGCTGGAGAAACTGAC
TCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACACA
GGACTGACTCCGGAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTG
GCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAACGTCATTGAAGTGCGGCTC
GATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATATC
GGAATCTGGTTTGACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTT
GTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTACCAGTACTCCTACAGTCAC
AATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTG
AAGGAGGGGACGCAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTT
AAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAGTTTTCGAAACAGTACTGG
TTTATTCTGTCTGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTG
AGCGTCCTCGTGGACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAG
AAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAGCATGAGAAGCTCAAGCTG
ATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCC
AGCTCAGCACCTTCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCAC
ACCAATGTGTGA
|
Protein Properties |
Number of Residues
| 1003 |
Molecular Weight
| 113968.4 |
Theoretical pI
| 6.52 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["366-386", "435-455", "539-559", "583-603", "624-644", "749-769", "802-822", "908-928"]
|
Protein Sequence
|
>Anoctamin-2
MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPC
GGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPG
HSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENK
SQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPR
VPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGI
NSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKI
GLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDY
WNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEE
RAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFA
SILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIY
GAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVF
DGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETD
SAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRL
DAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSH
NGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYW
FILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKL
MDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
|
External Links |
GenBank ID Protein
| 219809115 |
UniProtKB/Swiss-Prot ID
| Q9NQ90 |
UniProtKB/Swiss-Prot Entry Name
| ANO2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| FJ384095 |
GeneCard ID
| ANO2 |
GenAtlas ID
| ANO2 |
HGNC ID
| HGNC:1183 |
References |
General References
| Not Available |