| Identification |
|---|
| HMDB Protein ID
| CDBP02654 |
| Secondary Accession Numbers
| Not Available |
| Name
| Anoctamin-1 |
| Description
| Not Available |
| Synonyms
|
- Discovered on gastrointestinal stromal tumors protein 1
- Oral cancer overexpressed protein 2
- Transmembrane protein 16A
- Tumor-amplified and overexpressed sequence 2
|
| Gene Name
| ANO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular calcium activated chloride ch |
| Specific Function
| Acts as a calcium-activated chloride channel. Required for normal tracheal development |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.3 |
| SNPs
| ANO1 |
| Gene Sequence
|
>2961 bp
ATGAGGGTCAACGAGAAGTACTCGACGCTCCCGGCCGAGGACCGCAGCGTCCACATCATC
AACATCTGCGCCATCGAGGACATCGGCTACCTGCCGTCCGAGGGCACGCTGCTGAACTCC
TTATCTGTGGACCCTGATGCCGAGTGCAAGTATGGCCTGTACTTCAGGGACGGCCGGCGC
AAGGTGGACTACATCCTGGTGTACCATCACAAGAGGCCCTCGGGCAACCGGACCCTGGTC
AGGAGGGTGCAGCACAGCGACACCCCCTCTGGGGCTCGCAGCGTCAAGCAGGACCACCCC
CTGCCGGGCAAGGGGGCGTCGCTGGATGCAGGCTCGGGGGAGCCCCCGATGGACTACCAC
GAGGATGACAAGCGCTTCCGCAGGGAGGAGTACGAGGGCAACCTCCTGGAGGCGGGCCTG
GAGCTGGAGCGGGACGAGGACACTAAAATCCACGGAGTCGGGTTTGTGAAAATCCATGCC
CCCTGGAACGTGCTGTGCAGAGAGGCCGAGTTTCTGAAACTGAAGATGCCGACGAAGAAG
ATGTACCACATTAATGAGACCCGTGGCCTCCTGAAAAAAATCAACTCTGTGCTCCAGAAA
ATCACAGATCCCATCCAGCCCAAAGTGGCTGAGCACAGGCCCCAGACCATGAAGAGACTC
TCCTATCCCTTCTCCCGGGAGAAGCAGCATCTATTTGACTTGTCTGATAAGGATTCCTTT
TTCGACAGCAAAACCCGGAGCACGATTGTCTATGAGATCTTGAAGAGAACGACGTGTACA
AAGGCCAAGTACAGCATGGGCATCACGAGCCTGCTGGCCAATGGTGTGTACGCGGCTGCA
TACCCACTGCACGATGGAGACTACAACGGTGAAAACGTCGAGTTCAACGACAGAAAACTC
CTGTACGAAGAGTGGGCACGCTATGGAGTTTTCTATAAGTACCAGCCCATCGACCTGGTC
AGGAAGTATTTTGGGGAGAAGATCGGCCTGTACTTCGCCTGGCTGGGCGTGTACACCCAG
ATGCTCATCCCTGCCTCCATCGTGGGAATCATTGTCTTCCTGTACGGATGCGCCACCATG
GATGAAAACATCCCCAGCATGGAGATGTGTGACCAGAGACACAATATCACCATGTGCCCG
CTTTGCGACAAGACCTGCAGCTACTGGAAGATGAGCTCAGCCTGCGCCACGGCCCGCGCC
AGCCACCTCTTCGACAACCCCGCCACGGTCTTCTTCTCTGTCTTCATGGCCCTCTGGGCT
GCCACCTTCATGGAGCACTGGAAGCGGAAACAGATGCGACTCAACTACCGCTGGGACCTC
ACGGGCTTTGAAGAGGAAGAGGAGGCTGTCAAGGATCATCCTAGAGCTGAATACGAAGCC
AGAGTCTTGGAGAAGTCTCTGAAGAAAGAGTCCAGAAACAAAGAGAAGCGCCGGCATATT
CCAGAGGAGTCAACAAACAAATGGAAGCAGAGGGTTAAGACAGCCATGGCGGGGGTGAAA
TTGACTGACAAAGTGAAGCTGACATGGAGAGATCGGTTCCCAGCCTACCTCACTAACTTG
GTCTCCATCATCTTCATGATTGCAGTGACGTTTGCCATCGTCCTCGGCGTCATCATCTAC
AGAATCTCCATGGCCGCCGCCTTGGCCATGAACTCCTCCCCCTCCGTGCGGTCCAACATC
CGGGTCACAGTCACAGCCACCGCAGTCATCATCAACCTAGTGGTCATCATCCTCCTGGAC
GAGGTGTATGGCTGCATAGCCCGATGGCTCACCAAGATCGAGGTCCCAAAGACGGAGAAA
AGCTTTGAGGAGAGGCTGATCTTCAAGGCTTTCCTGCTGAAGTTTGTGAATTCCTACACC
CCCATCTTTTACGTGGCGTTCTTCAAAGGCCGGTTTGTTGGACGCCCGGGCGACTACGTG
TACATTTTCCGTTCCTTCCGAATGGAAGAGTGTGCGCCAGGGGGCTGCCTGATGGAGCTA
TGCATCCAGCTCAGCATCATCATGCTGGGGAAACAGCTGATCCAGAACAACCTGTTCGAG
ATCGGCATCCCGAAGATGAAGAAGCTCATCCGCTACCTGAAGCTGAAGCAGCAGAGCCCC
CCTGACCACGAGGAGTGTGTGAAGAGGAAACAGCGGTACGAGGTGGATTACAACCTGGAG
CCCTTCGCGGGCCTCACCCCAGAGTACATGGAAATGATCATCCAGTTTGGCTTCGTCACC
CTGTTTGTCGCCTCCTTCCCCCTGGCCCCACTGTTTGCGCTGCTGAACAACATCATCGAG
ATCCGCCTGGACGCCAAAAAGTTTGTCACTGAGCTCCGAAGGCCGGTAGCTGTCAGAGCC
AAAGACATCGGAATCTGGTACAATATCCTCAGAGGCATTGGGAAGCTTGCTGTCATCATC
AATGCCTTCGTGATCTCCTTCACGTCTGACTTCATCCCGCGCCTGGTGTACCTCTACATG
TACAGTAAGAACGGGACCATGCACGGCTTCGTCAACCACACCCTCTCCTCCTTCAACGTC
AGTGACTTCCAGAACGGCACGGCCCCCAATGACCCCCTGGACCTGGGCTACGAGGTGCAG
ATCTGCAGGTATAAAGACTACCGAGAGCCGCCGTGGTCGGAAAACAAGTACGACATCTCC
AAGGACTTCTGGGCCGTCCTGGCAGCCCGGCTGGCGTTTGTCATCGTCTTCCAGAACCTG
GTCATGTTCATGAGCGACTTTGTGGACTGGGTCATCCCGGACATCCCCAAGGACATCAGC
CAGCAGATCCACAAGGAGAAGGTGCTCATGGTGGAGCTGTTCATGCGGGAGGAGCAAGAC
AAGCAGCAGCTGCTGGAAACCTGGATGGAGAAGGAGCGGCAGAAGGACGAGCCGCCGTGC
AACCACCACAACACCAAAGCCTGCCCAGACAGCCTCGGCAGCCCAGCCCCCAGCCATGCC
TACCACGGGGGCGTCCTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 986 |
| Molecular Weight
| 114077.2 |
| Theoretical pI
| 8.71 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["334-354", "403-423", "520-540", "566-586", "607-627", "732-752", "792-812", "883-903"]
|
| Protein Sequence
|
>Anoctamin-1
MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRR
KVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYH
EDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK
MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSF
FDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKL
LYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM
DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWA
ATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHI
PEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIY
RISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEK
SFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMEL
CIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLE
PFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRA
KDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNV
SDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNL
VMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPC
NHHNTKACPDSLGSPAPSHAYHGGVL
|
| External Links |
|---|
| GenBank ID Protein
| 194306539 |
| UniProtKB/Swiss-Prot ID
| Q5XXA6 |
| UniProtKB/Swiss-Prot Entry Name
| ANO1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018043.5 |
| GeneCard ID
| ANO1 |
| GenAtlas ID
| ANO1 |
| HGNC ID
| HGNC:21625 |
| References |
|---|
| General References
| Not Available |