Identification |
HMDB Protein ID
| CDBP02645 |
Secondary Accession Numbers
| Not Available |
Name
| Sodium/hydrogen exchanger 10 |
Description
| Not Available |
Synonyms
|
- NHE-10
- Na(+)/H(+) exchanger 10
- Solute carrier family 9 member 10
- Sperm-specific Na(+)/H(+) exchanger
- sNHE
|
Gene Name
| SLC9A10 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in solute:hydrogen antiporter activity |
Specific Function
| Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) |
GO Classification
|
Component |
intrinsic to membrane |
integral to membrane |
cell part |
membrane part |
Function |
solute:cation antiporter activity |
solute:hydrogen antiporter activity |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
cation transmembrane transporter activity |
transporter activity |
Process |
establishment of localization |
transport |
transmembrane transport |
ion transport |
cation transport |
|
Cellular Location
|
- Multi-pass membrane protein
- Cell projection
- cilium
- flagellum membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:3 |
Locus
| 3q13.2 |
SNPs
| SLC9A10 |
Gene Sequence
|
>3534 bp
ATGGCTGGAATATTTAAGGAGTTTTTTTTCAGTACTGAGGACCTCCCTGAAGTCATTCTA
ACATTGTCTTTGATCAGCTCCATTGGAGCATTTTTGAACCGGCACTTGGAAGACTTTCCA
ATTCCTGTCCCTGTGATATTATTTTTACTTGGATGCAGTTTTGAAGTATTAAGCTTTACA
TCTTCACAGGTCCAAAGATACGCAAACGCCATACAATGGATAAGTCCAGACTTATTTTTT
CGTATATTTACACCAGTAGTTTTCTTTACTACTGCATTTGACATGGATACGTACATGCTT
CAAAAGTTATTTTGGCAGATACTTTTAATTTCAATTCCCGGCTTTTTGGTTAATTATATC
TTAGTTCTTTGGCATCTGGCATCTGTAAATCAATTACTTTTGAAGCCTACCCAATGGTTA
TTATTTTCAGCTATCCTTGTGAGTTCAGATCCCATGCTAACCGCAGCTGCTGTAAGAGAC
CTTGGGCTTTCTAGAAGCCTCATCAGTTTAATTAATGGAGAAAGTCTGATGACCTCTGTT
ATATCATTAATTACATTTACTAGTATTATGGATTTTGACCAAAGACTACAAAGTAAAAGA
AACCATACCTTAGCTGAAGAGATCGTGGGTGGAATTTGTTCATATATTATAGCAAGTTTC
TTGTTTGGAATTCTAAGTTCAAAACTGATTCAATTTTGGATGTCAACTGTTTTTGGTGAT
GATGTCAATCATATAAGTCTCATCTTTTCAATTCTGTATCTCATCTTTTATATTTGTGAG
TTAGTTGGAATGTCAGGAATATTTACTCTGGCCATTGTGGGACTTCTTTTAAATTCTACA
AGTTTTAAAGCAGCAGTTGAAGAAACACTTCTTCTTGAATTCTGGACTTTTCTATCACGT
ATTGCTTTTCTCATGGTGTTTACTTTCTTTGGACTTCTAATTCCTGCACATACATATTTG
TATATAGAATTTGTTGATATATACTATTCATTAAATATCTACTTAACATTGATTGTTTTA
AGATTTCTGACCCTTCTTTTAATGAGCCCTGTTTTGTCTCGAGTTGGTCATGAGTTCAGT
TGGCGCTGGGTATTCATAATGGTCTGTAGTGAAATGAAAGGGATGCCTAATATAAACATG
GCCCTTCTGCTTGCCTACTCTGATCTTTATTTTGGATCTGACAAAGAAAAATCTCAAATA
TTATTTCATGGAGTGTTAGTATGCCTAATAACCCTTGTTGTCAATAGATTTATTTTGCCA
GTGGCAGTTGCTATACTAGGTCTTCGTGATGCCACATCAACAAAATATAAATCGGTTTGT
TGCACATTTCAACACTTTCAAGAGCTAACCAAGTCTGCAGCCTCTGCCCTTAAATTTGAC
AAAGATCTTGCTAATGCTGATTGGAACATGATTGAGAAAGCAATTACACTTGAAAACCCA
TACATGTTGAACGAAGAAGAAACAACAGAACATCAGAAGGTGAAATGTCCACACTGTAAC
AAGGAAATAGATGAGATCTTTAACACTGAAGCAATGGAGCTGGCCAACAGGCGTCTCTTG
TCAGCACAAATAGCAAGCTACCAGAGACAATACAGGAATGAGATTCTGTCCCAGAGTGCT
GTCCAGGTGTTGGTTGGTGCAGCAGAAAGTTTTGGTGAGAAGAAGGGAAAATGTATGAGT
CTTGATACAATAAAGAATTATTCTGAAAGCCAAAAAACAGTTACCTTTGCTAGAAAACTA
CTACTTAATTGGGTGTATAATACCAGAAAGGAAAAAGAGGGCCCATCAAAATACTTCTTT
TTTCGTATATGCCATACAATAGTATTTACTGAGGAATTTGAACATGTTGGATACCTTGTG
ATATTAATGAATATATTTCCCTTTATAATCTCTTGGATATCCCAGTTAAATGTAATCTAC
CACAGCGAATTAAAACACACTAACTACTGTTTTCTTACACTTTATATTCTAGAGGCACTA
CTTAAGATAGCAGCAATGAGGAAGGACTTTTTTTCACATGCCTGGAACATATTCGAGTTA
GCAATTACATTAATTGGCATCTTACATGTAATACTTATTGAAATAGACACCATTAAGTAT
ATTTTTAATGAGATTGAAGTAATAGTCTTTATAAAAGTTGTTCAATTTTTTCGTATACTA
CGCATTTTCAAGCTCATAGCACCAAAGTTGCTGAAAATAATAGATAAAAGAATGAGTCAT
CAGAAGACCTTTTGGTATGGAATACTAAAAGGCTATGTCCAAGGCGAAGCAGACATAATG
ACCATAATTGATCAGATTACAATTTCTAAACAGATTAAACAGATGTTATTAAAGCAAGTG
ATAAGGAATATGGACCATGCTACAAAAGAGCTAGGCTACTTAGAGTATGATCACCCAGAA
ATTGCTGTCACTGTGAAAACAAAGGAAGAAATTAATGTTATGCTCAATATGGCTACAGAA
ATTCTTAAGGCTTTCAGCTTAAAAGGAATTATTAGTAAAACTGAAGGTGCTGGAATTAAT
AAGTTAATCATGGCCAAAAAGAAAGAGGTGCTTGATTCTCAATCTATTATCAGGCCTCTT
ACTGTTGAAGAAGTTCTATATCATATTCCGTGGCTAGATAAAAACAAAGATTATATAAAC
TTCATTCAGGAAAAAGCCAAAGTTGTAACATTTGATTGTGGAAATGATATATTTGAAGAA
GGTGATGAGCCCAAAGGAATCTATATCATTATTTCAGGCATGGTAAAGCTTGAAAAATCA
AAGCCAGGTTTAGGGATTGATCAAATGGTGGAGTCAAAGGAGAAAGATTTTCCGATAATT
GACACAGACTATATGCTCAGTGGAGAAATAATAGGAGAGATAAACTGCTTAACTAATGAA
CCTATGAAATATTCTGCCACCTGCAAAACTGTAGTGGAGACATGTTTTATTCCCAAAACT
CACTTGTATGATGCTTTTGAGCAATGCTCTCCTCTCATTAAACAAAAAATGTGGCTAAAA
CTTGGACTCGCTATTACAGCCAGAAAAATCAGAGAACACTTATCTTATGAGGATTGGAAC
TACAATATGCAACTAAAGCTCTCTAATATTTATGTAGTAGATATACCAATGAGTACCAAA
ACTGATATTTATGATGAAAATCTAATCTATGTTATCCTCATACATGGAGCTGTAGAAGAT
TGTCTGTTACGAAAAACTTATAGAGCACCTTTCTTAATTCCTATAACATGCCATCAGATA
CAAAGTATTGAAGATTTCACAAAAGTAGTGATTATTCAAACTCCGATTAACATGAAAACA
TTCAGAAGGAATATTAGAAAGTTTGTTCCTAAACATAAAAGTTATCTTACACCAGGATTA
ATAGGTTCAGTTGGAACATTGGAAGAAGGCATTCAAGAAGAAAGAAATGTTAAGGAGGAT
GGAGCACACAGTGCCGCCACTGCCAGGAGTCCCCAGCCTTGCTCCCTGCTGGGGACAAAG
TTCAACTGTAAGGAGTCCCCTAGAATAAACCTAAGGAAAGTCAGGAAAGAGTAA
|
Protein Properties |
Number of Residues
| 1177 |
Molecular Weight
| 135204.6 |
Theoretical pI
| 7.14 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["8-28", "39-59", "73-93", "103-123", "138-158", "167-187", "204-224", "248-268", "301-321", "333-353", "364-384", "405-425", "613-633", "646-666", "675-695", "707-727"]
|
Protein Sequence
|
>Sodium/hydrogen exchanger 10
MAGIFKEFFFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFT
SSQVQRYANAIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYI
LVLWHLASVNQLLLKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSV
ISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIASFLFGILSSKLIQFWMSTVFGD
DVNHISLIFSILYLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEETLLLEFWTFLSR
IAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFS
WRWIFIMVCSEMKGMPNINMALLLAYSDLYFGSDKEKSQILFHGVLVCLITLVVNRFILP
VAVTILGLRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDLANADWNMIEKAITLENP
YMLNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANRRLLSAQIASYQRQYRNEILSQSA
VQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGPSKYFF
FRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSELKHTNYCFLTLYILEAL
LKIAAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRIL
RIFKLIAPKLLQIIDKRMSHQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQV
IRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGIN
KLIMAKKKEVLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEE
GDEPKGIYIIISGMVKLEKSKPGLGIDQMVESKEKDFPIIDTDYMLSGEIIGEINCLTNE
PMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWN
YNMQLKLSNIYVVDIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQI
QSIEDFTKVVIIQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTLEEGIQEERNVKED
GAHSAATARSPQPCSLLGTKFNCKESPRINLRKVRKE
|
External Links |
GenBank ID Protein
| 34535281 |
UniProtKB/Swiss-Prot ID
| Q4G0N8 |
UniProtKB/Swiss-Prot Entry Name
| S9A10_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK128084 |
GeneCard ID
| SLC9A10 |
GenAtlas ID
| SLC9A10 |
HGNC ID
| HGNC:31401 |
References |
General References
| Not Available |