| Identification |
|---|
| HMDB Protein ID
| CDBP02642 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bestrophin-4 |
| Description
| Not Available |
| Synonyms
|
- Vitelliform macular dystrophy 2-like protein 2
|
| Gene Name
| BEST4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Forms calcium-sensitive chloride channels. Permeable to bicarbonate |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p33-p32.3 |
| SNPs
| BEST4 |
| Gene Sequence
|
>1422 bp
ATGACGGTTTCATACACTCTCAAAGTGGCGGAGGCCCGCTTCGGAGGTTTCTCTGGCCTG
CTTCTCCGCTGGAGGGGAAGCATCTACAAGCTCCTCTACAAGGAATTCCTCCTCTTTGGG
GCCTTGTACGCTGTGCTTAGCATCACCTACCGGCTGCTGCTGACCCAGGAGCAGAGGTAC
GTGTATGCTCAGGTGGCCCGGTACTGCAACCGCTCAGCAGACCTCATTCCCTTGTCCTTT
GTATTGGGTTTCTATGTGACTCTCGTGGTGAACCGCTGGTGGTCCCAGTACACAAGCATC
CCGCTGCCAGACCAGCTGATGTGCGTCATCTCGGCTAGCGTGCACGGCGTGGACCAGCGG
GGCCGCCTGCTGCGCCGCACCCTCATCCGCTACGCGAACCTGGCGTCCGTGCTGGTGCTG
CGCTCGGTCAGCACCCGCGTGCTTAAGCGCTTCCCCACCATGGAGCACGTGGTGGACGCA
GGTTTCATGTCCCAGGAAGAGAGGAAAAAGTTTGAGAGCCTGAAATCCGACTTCAACAAG
TACTGGGTCCCCTGCGTCTGGTTCACCAACCTGGCGGCCCAGGCCCGGAGGGACGGGCGA
ATACGTGACGATATCGCTCTCTGTCTACTTTTGGAAGAGCTGAACAAGTACCGAGCCAAG
TGCAGCATGCTATTCCACTATGACTGGATCAGCATCCCCCTCGTCTACACCCAAGTGGTG
ACCATAGCCGTCTACTCTTTCTTTGCCCTCTCCCTGGTTGGCCGCCAGTTTGTGGAGCCA
GAGGCAGGGGCTGCCAAACCTCAGAAGCTTCTGAAGCCAGGCCAGGAGCCAGCCCCAGCC
CTGGGAGACCCGGACATGTACGTGCCTCTCACCACTCTGCTGCAGTTCTTCTTCTATGCT
GGCTGGCTCAAGGTGGCTGAACAGATCATCAACCCATTTGGTGAGGATGATGACGACTTT
GAGACAAATCAGCTCATAGACCGCAACTTGCAGGTGTCCCTGCTATCCGTGGACGAAATG
TACCAGAACCTTCCCCCCGCTGAGAAGGACCAGTACTGGGATGAGGACCAGCCGCAGCCA
CCCTACACTGTGGCCACGGCGGCCGAGTCTCTGCGGCCCTCATTCCTGGGCTCCACCTTC
AACCTGCGCATGAGCGACGACCCTGAGCAGAGCCTGCAGGTGGAGGCGTCCCCCGGATCT
GGTCGGCCCGCGCCCGCCGCGCAGACCCCGTTGCTCGGCCGCTTCCTGGGCGTAGGGGCG
CCCTCCCCGGCCATCAGCCTCCGGAACTTCGGCCGCGTGCGAGGCACCCCCCGCCCCCCG
CATCTGCTGCGCTTCCGGGCGGAGGAGGGCGGCGACCCCGAGGCCGCAGCCCGCATCGAG
GAGGAATCGGCGGAGTCCGGGGACGAGGCCCTGGAGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 473 |
| Molecular Weight
| 53496.7 |
| Theoretical pI
| 5.87 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["26-46", "71-91", "179-199", "286-306"]
|
| Protein Sequence
|
>Bestrophin-4
MTVSYTLKVAEARFGGFSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQEQRY
VYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVHGVDQR
GRLLRRTLIRYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESLKSDFNK
YWVPCVWFTNLAAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVV
TIAVYSFFALSLVGRQFVEPEAGAAKPQKLLKPGQEPAPALGDPDMYVPLTTLLQFFFYA
GWLKVAEQIINPFGEDDDDFETNQLIDRNLQVSLLSVDEMYQNLPPAEKDQYWDEDQPQP
PYTVATAAESLRPSFLGSTFNLRMSDDPEQSLQVEASPGSGRPAPAAQTPLLGRFLGVGA
PSPAISLRNFGRVRGTPRPPHLLRFRAEEGGDPEAAARIEEESAESGDEALEP
|
| External Links |
|---|
| GenBank ID Protein
| 21734842 |
| UniProtKB/Swiss-Prot ID
| Q8NFU0 |
| UniProtKB/Swiss-Prot Entry Name
| BEST4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF440757 |
| GeneCard ID
| BEST4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |