| Identification |
|---|
| HMDB Protein ID
| CDBP02641 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bestrophin-3 |
| Description
| Not Available |
| Synonyms
|
- Vitelliform macular dystrophy 2-like protein 3
|
| Gene Name
| BEST3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Forms calcium-sensitivechloride channels. Permeable to bicarbonate |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q14.2-q15 |
| SNPs
| BEST3 |
| Gene Sequence
|
>2007 bp
ATGACTGTCACTTACTCCAGTAAAGTAGCAAATGCAACTTTTTTTGGATTTCATAGGTTA
CTCCTCAAGTGGAGAGGCAGCATCTACAAACTACTGTACAGGGAATTTATTGTTTTTGCT
GTTCTTTATACAGCAATAAGTTTGGTATACAGATTGTTACTTACAGGAGTCCAAAAACGT
TACTTTGAAAAATTATCAATTTACTGTGACAGATATGCTGAACAAATTCCAGTAACCTTT
GTGCTTGGGTTTTATGTTACTCTGGTAGTGAACCGATGGTGGAACCAGTTTGTGAATTTG
CCCTGGCCAGACAGGCTAATGTTCCTCATCTCTAGCAGTGTTCACGGAAGCGACGAGCAC
GGGCGCCTGCTTAGAAGGACGCTGATGCGCTACGTCAATCTCACCTCCCTGCTCATCTTT
CGCTCGGTGAGCACTGCTGTGTACAAAAGATTTCCCACAATGGACCACGTGGTTGAAGCA
GGTTTTATGACAACAGATGAAAGGAAATTATTCAACCACCTCAAGTCTCCTCATCTGAAA
TATTGGGTTCCATTCATCTGGTTTGGAAATCTTGCAACTAAAGCCCGGAATGAAGGTAGA
ATCAGAGACAGTGTTGATCTGCAATCATTGATGACTGAAATGAATCGATACCGCTCTTGG
TGCAGCCTCTTATTCGGTTATGACTGGGTTGGGATTCCGCTGGTTTACACCCAGGTTGTC
ACTCTTGCTGTCTATACCTTCTTCTTTGCGTGCCTGATTGGACGCCAGTTTTTGGATCCC
ACCAAAGGCTACGCAGGGCATGACTTGGATCTTTACATTCCCATCTTCACCCTCCTACAA
TTCTTCTTCTATGCAGGATGGCTTAAGGTAGCAGAGCAGCTTATCAACCCTTTTGGAGAA
GATGATGATGATTTTGAAACTAACTGGTGCATTGACAGAAATTTGCAGGTCTCTCTTTTA
GCTGTGGACGAAATGCACATGAGCTTACCCAAGATGAAGAAGGACATTTACTGGGACGAT
TCTGCTGCTCGCCCACCATACACATTGGCAGCTGCTGACTACTGCATACCCTCATTTCTG
GGGTCAACAGTCCAGATGGGGCTGTCTGGGTCCGACTTTCCTGACGAGGAGTGGCTGTGG
GATTATGAGAAGCATGGCCATCGGCATTCCATGATAAGAAGAGTCAAGCGGTTCCTGAGT
GCCCACGAACACCCCTCCAGCCCCAGAAGAAGAAGCTACAGGAGGCAGACAAGTGACAGC
TCCATGTTCTTACCCCGAGATGACCTCAGCCCAGCCAGGGACCTACTGGATGTGCCCTCA
AGAAACCCCCCCAGGGCCTCACCCACCTGGAAGAAATCCTGCTTCCCAGAAGGAAGCCCC
ACGCTGCACTTCAGCATGGGAGAGCTGTCCACCATCAGGGAGACCAGCCAGACAAGCACT
TTACAGAGCCTGACCCCACAGTCCAGTGTGAGAACTTCCCCCATCAAAATGCCACTGGTA
CCTGAGGTATTGATCACAGCAGCCGAAGCACCAGTGCCCACATCAGGGGGCTACCACCAT
GATTCCGCTACCTCCATCTTGAGCTCTGAGTTTACAGGGGTTCAGCCAAGCAAGACTGAG
CAGCAGCAGGGCCCCATGGGATCCATCCTGTCTCCCTCAGAGAAGGAGACACCTCCTGGA
GGCCCCAGTCCCCAGACAGTTTCAGCCAGCGCTGAGGAAAATATATTCAACTGTGAAGAA
GACCCTGGTGATACCTTTCTAAAAAGGTGGAGTCTTCCGGGATTCCTGGGGTCCAGCCAC
ACTTCCCTGGGAAACCTAAGTCCAGACCCCATGAGCTCTCAGCCAGCTCTTTTAATTGAC
ACAGAAACATCCTCAGAGATCAGTGGGATCAACATTGTGGCTGGCTCTCGAGTCTCTTCT
GATATGCTGTATTTAATGGAAAACCTGGACACCAAGGAAACAGATATCATAGAGCTGAAC
AAGGAAACTGAGGAATCACCCAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 668 |
| Molecular Weight
| 76106.0 |
| Theoretical pI
| 6.56 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["26-46", "71-91", "179-199", "271-291"]
|
| Protein Sequence
|
>Bestrophin-3
MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKR
YFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEH
GRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLK
YWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVV
TLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGE
DDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFL
GSTVQMGLSGSDFPDEEWLWDYEKHGHRHSMIRRVKRFLSAHEHPSSPRRRSYRRQTSDS
SMFLPRDDLSPARDLLDVPSRNPPRASPTWKKSCFPEGSPTLHFSMGELSTIRETSQTST
LQSLTPQSSVRTSPIKMPLVPEVLITAAEAPVPTSGGYHHDSATSILSSEFTGVQPSKTE
QQQGPMGSILSPSEKETPPGGPSPQTVSASAEENIFNCEEDPGDTFLKRWSLPGFLGSSH
TSLGNLSPDPMSSQPALLIDTETSSEISGINIVAGSRVSSDMLYLMENLDTKETDIIELN
KETEESPK
|
| External Links |
|---|
| GenBank ID Protein
| 115527104 |
| UniProtKB/Swiss-Prot ID
| Q8N1M1 |
| UniProtKB/Swiss-Prot Entry Name
| BEST3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_032735.2 |
| GeneCard ID
| BEST3 |
| GenAtlas ID
| BEST3 |
| HGNC ID
| HGNC:17105 |
| References |
|---|
| General References
| Not Available |