Cannabis Compound Database: Showing Protein Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (CDBP02619)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02619

Secondary Accession Numbers

Not Available

Name

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Description

Not Available

Synonyms

PTEN-like phosphatase
Phosphoinositide lipid phosphatase
Protein-tyrosine phosphatase mitochondrial 1

Gene Name

PTPMT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).

GO Classification

Biological Process
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
inositol phosphate dephosphorylation
cardiolipin biosynthetic process
Cellular Component
mitochondrion
mitochondrial inner membrane
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
phosphatidylglycerophosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process

Cellular Location

Mitochondrion inner membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Inositol Metabolism
phosphatidylglycerol biosynthesis	Not Available	Not Available
Phospholipid Biosynthesis
Cardiolipin Biosynthesis CL(i-13:0/i-16:0/i-13:0/i-17:0)		Not Available
Cardiolipin Biosynthesis CL(i-14:0/i-15:0/i-20:0/i-18:0)		Not Available

Gene Properties

Chromosome Location

Locus

11p11.2

SNPs

PTPMT1

Gene Sequence

>606 bp
ATGGCGGCCACCGCGCTGCTGGAGGCCGGCCTGGCGCGGGTGCTCTTCTACCCGACGCTG
CTCTACACCCTGTTCCGCGGGAAGGTGCCGGGTCGGGCGCACCGGGACTGGTACCACCGC
ATCGACCCCACCGTGCTGCTGGGCGCGCTGCCGTTGCGGAGCTTGACGCGCCAGCTGGTA
CAGGACGAGAACGTGCGCGGGGTGATCACCATGAACGAGGAGTACGAGACGAGGTTCCTG
TGCAACTCTTCACAGGAGTGGAAGAGACTAGGAGTCGAGCAGCTGCGGCTCAGCACAGTA
GACATGACTGGGATCCCCACCTTGGACAACCTCCAGAAGGGAGTCCAATTTGCTCTCAAG
TACCAGTCGCTGGGCCAGTGTGTTTACGTGCATTGTAAGGCTGGGCGCTCCAGGAGTGCC
ACTATGGTGGCAGCATACCTGATTCAGGTGCACAAATGGAGTCCAGAGGAGGCTGTAAGA
GCCATCGCCAAGATCCGGTCATACATCCACATCAGGCCTGGCCAGCTGGATGTTCTTAAA
GAGTTCCACAAGCAGATTACTGCACGGGCAACAAAGGATGGGACTTTTGTCATTTCAAAG
ACATGA

Protein Properties

Number of Residues

201

Molecular Weight

16458.74

Theoretical pI

10.96

Pfam Domain Function

DSPc (PF00782 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Protein-tyrosine phosphatase mitochondrial 1
MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLV
QDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALK
YQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLK
EFHKQITARATKDGTFVISKT

External Links

GenBank ID Protein

148224884

UniProtKB/Swiss-Prot ID

Q8WUK0

UniProtKB/Swiss-Prot Entry Name

PTPM1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_175732.2

GeneCard ID