| Identification |
|---|
| HMDB Protein ID
| CDBP02617 |
| Secondary Accession Numbers
| Not Available |
| Name
| Multiple inositol polyphosphate phosphatase 1 |
| Description
| Not Available |
| Synonyms
|
- Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
- Ins(1,3,4,5)P(4) 3-phosphatase
- 2,3-bisphosphoglycerate 3-phosphatase
- 2,3-BPG phosphatase
|
| Gene Name
| MINPP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid phosphatase activity |
| Specific Function
| Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification).
|
| GO Classification
|
| Biological Process |
| bone mineralization |
| polyphosphate metabolic process |
| Cellular Component |
| endoplasmic reticulum |
| endoplasmic reticulum lumen |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| acid phosphatase activity |
| Molecular Function |
| inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity |
| phosphohistidine phosphatase activity |
| acid phosphatase activity |
| bisphosphoglycerate 3-phosphatase activity |
| inositol hexakisphosphate 2-phosphatase activity |
| inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity |
|
| Cellular Location
|
- Endoplasmic reticulum lumen
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Inositol Metabolism |    |  | | Inositol Phosphate Metabolism |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q23 |
| SNPs
| MINPP1 |
| Gene Sequence
|
>1464 bp
ATGCTACGCGCGCCCGGCTGCCTCCTCCGGACCTCCGTAGCGCCTGCCGCGGCCCTGGCT
GCGGCGCTGCTCTCGTCGCTTGCGCGCTGCTCTCTTCTAGAGCCGAGGGACCCGGTGGCC
TCGTCGCTCAGCCCCTATTTCGGCACCAAGACTCGCTACGAGGATGTCAACCCCGTGCTA
TTGTCGGGCCCCGAGGCTCCGTGGCGGGACCCTGAGCTGCTGGAGGGGACCTGCACCCCG
GTGCAGCTGGTCGCCCTCATTCGCCACGGCACCCGCTACCCCACGGTCAAACAGATCCGC
AAGCTGAGGCAGCTGCACGGGTTGCTGCAGGCCCGCGGGTCCAGGGATGGCGGGGCTAGT
AGTACCGGCAGCCGCGACCTGGGTGCAGCGCTGGCCGACTGGCCTTTGTGGTACGCGGAC
TGGATGGACGGGCAGCTAGTAGAGAAGGGACGGCAGGATATGCGACAGCTGGCGCTGCGT
CTGGCCTCGCTCTTCCCGGCCCTTTTCAGCCGTGAGAACTACGGCCGCCTGCGGCTCATC
ACCAGTTCCAAGCACCGCTGCATGGATAGCAGCGCCGCCTTCCTGCAGGGGCTGTGGCAG
CACTACCACCCTGGCTTGCCGCCGCCGGACGTCGCAGATATGGAGTTTGGACCTCCAACA
GTTAATGATAAACTAATGAGATTTTTTGATCACTGTGAGAAGTTTTTAACTGAAGTAGAA
AAAAATGCTACAGCTCTTTATCACGTGGAAGCCTTCAAAACTGGACCAGAAATGCAGAAC
ATTTTAAAAAAAGTTGCAGCTACTTTGCAAGTGCCAGTAAATGATTTAAATGCAGATTTA
ATTCAAGTAGCCTTTTTCACCTGTTCATTTGACCTGGCAATTAAAGGTGTTAAATCTCCT
TGGTGTGATGTTTTTGACATAGATGATGCAAAGGTATTAGAATATTTAAATGATCTGAAA
CAATATTGGAAAAGAGGATATGGGTATACTATTAACAGTCGATCCAGCTGCACCTTGTTT
CAGGATATCTTTCAGCACTTGGACAAAGCAGTTGAACAGAAACAAAGGTCTCAGCCAATT
TCTTCTCCAGTCATCCTCCAGTTTGGTCATGCAGAGACTCTTCTTCCACTGCTTTCTCTC
ATGGGCTACTTCAAAGACAAGGAACCCCTAACAGCGTACAATTACAAAAAACAAATGCAT
CGGAAGTTCCGAAGTGGTCTCATTGTACCTTATGCCTCGAACCTGATATTTGTGCTTTAC
CACTGTGAAAATGCTAAGACTCCTAAAGAACAATTCCGAGTGCAGATGTTATTAAATGAA
AAGGTGTTACCTTTGGCTTACTCACAAGAAACTGTTTCATTTTATGAAGATCTGAAGAAC
CACTACAAGGACATCCTTCAGAGTTGTCAAACCAGTGAAGAATGTGAATTAGCAAGGGCT
AACAGTACATCTGATGAACTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 487 |
| Molecular Weight
| 34660.555 |
| Theoretical pI
| 8.97 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Multiple inositol polyphosphate phosphatase 1
MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVL
LSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGAS
STGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLI
TSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVE
KNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSP
WCDVFDIDDAKVLEYLNDLKQYWKRGYGYTINSRSSCTLFQDIFQHLDKAVEQKQRSQPI
SSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMHRKFRSGLIVPYASNLIFVLY
HCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARA
NSTSDEL
|
| External Links |
|---|
| GenBank ID Protein
| 19923761 |
| UniProtKB/Swiss-Prot ID
| Q9UNW1 |
| UniProtKB/Swiss-Prot Entry Name
| MINP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004897.4 |
| GeneCard ID
| MINPP1 |
| GenAtlas ID
| MINPP1 |
| HGNC ID
| HGNC:7102 |
| References |
|---|
| General References
| Not Available |