| Identification |
|---|
| HMDB Protein ID
| CDBP02613 |
| Secondary Accession Numbers
| Not Available |
| Name
| UDP-glucose:glycoprotein glucosyltransferase 2 |
| Description
| Not Available |
| Synonyms
|
- UDP--Glc:glycoprotein glucosyltransferase 2
- UDP-glucose ceramide glucosyltransferase-like 1
- UGT2
- hUGT2
|
| Gene Name
| UGGT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring glycosyl groups |
| Specific Function
| Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation |
| GO Classification
|
| Function |
| udp-glucose:glycoprotein glucosyltransferase activity |
| catalytic activity |
| transferase activity |
| udp-glycosyltransferase activity |
| transferase activity, transferring glycosyl groups |
| udp-glucosyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
| protein modification process |
| protein amino acid glycosylation |
|
| Cellular Location
|
- Endoplasmic reticulum lumen
- Endoplasmic reticulum-Golgi intermediate compartment
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q32.1 |
| SNPs
| UGGT2 |
| Gene Sequence
|
>4551 bp
ATGGCGCCAGCGAAAGCCACGAACGTGGTGCGGCTGCTACTAGGCTCCACAGCGCTGTGG
CTTTCGCAGCTCGGCTCCGGGACGGTCGCCGCGTCCAAGTCGGTGACTGCCCACTTGGCC
GCGAAGTGGCCCGAGACCCCGCTGCTGCTGGAGGCAAGTGAATTTATGGCAGAAGAAAGT
AATGAAAAATTTTGGCAGTTTTTGGAAACTGTGCAAGAATTAGCAATTTATAAGCAAACA
GAATCAGATTATTCTTATTACAACTTAATCCTGAAGAAAGCTGGACAGTTTCTAGACAAT
TTACACATCAACCTTTTAAAGTTTGCTTTCTCTATAAGGGCATACTCCCCAGCTATTCAG
ATGTTTCAGCAGATTGCAGCTGATGAGCCACCACCAGATGGTTGTAATGCATTTGTGGTT
ATTCATAAGAAGCACACCTGTAAAATTAATGAGATTAAAAAGCTGCTGAAGAAAGCTGCT
TCAAGGACTAGACCTTATCTATTTAAAGGAGATCACAAATTTCCTACAAACAAAGAGAAC
TTACCAGTGGTGATTCTCTATGCCGAAATGGGTACTAGAACATTTAGTGCATTTCACAAA
GTATTGTCTGAAAAAGCTCAAAATGAGGAAATTCTGTATGTTCTTCGCCATTATATTCAG
AAACCAAGCTCACGGAAAATGTACTTATCTGGGTATGGTGTGGAGCTAGCAATTAAGAGT
ACAGAATACAAAGCACTGGATGATACCCAAGTTAAAACTGTGACTAATACTACTGTAGAG
GATGAGACTGAAACAAATGAAGTTCAAGGATTTCTCTTTGGGAAACTAAAAGAAATATAT
TCAGATCTTAGAGATAATCTGACAGCATTCCAAAAATACCTGATTGAGAGTAACAAACAA
ATGATGCCTTTGAAAGTCTGGGAACTACAAGATCTTAGTTTTCAAGCAGCTTCTCAAATA
ATGTCCACTCCAGTTTATGATGCCATTAAATTAATGAAAGACATTTCACAGAACTTCCCC
ATAAAAGCCAGATCTCTAACCAGAATTGCTGTAAATCAACATATGAGAGAAGAAATAAAG
GAAAATCAAAAGGATCTTCAAGTTAGATTTAAAATTCAGCCAGGCGATGCTCGTCTATTT
ATAAATGGCCTTCGTGTTGATATGGATGTTTATGACGCTTTTAGTATTTTGGATATGCTG
AAATTAGAAGGAAAAATGATGAATGGCCTTCGCAATCTTGGGATCAATGGGGAAGATATG
AGCAAATTTTTAAAATTAAATTCACACATTTGGGAATATACTTATGTATTAGATATTCGA
CATTCTTCTATAATGTGGATTAATGACTTAGAAAATGATGATTTGTATATTACATGGCCT
ACAAGTTGCCAGAAACTTCTGAAGCCAGTATTTCCTGGAAGTGTACCTTCCATAAGGCGC
AATTTTCATAATTTGGTTCTGTTTATTGATCCGGCCCAAGAATATACCTTGGATTTTATA
AAACTTGCTGATGTTTTCTATTCTCACGAAGTTCCTCTTAGAATTGGTTTTGTGTTCATT
CTTAATACAGATGATGAAGTTGATGGAGCAAATGATGCTGGAGTTGCTCTCTGGCGAGCT
TTCAACTATATTGCAGAAGAATTTGATATATCAGAAGCATTTATTTCTATAGTACACATG
TACCAAAAAGTGAAGAAGGATCAAAATATACTCACTGTGGACAATGTGAAGAGTGTTCTC
CAAAATACATTTCCTCATGCTAATATTTGGGATATTTTGGGAATTCATTCTAAATATGAT
GAAGAAAGAAAGGCTGGAGCAAGCTTTTATAAGATGACTGGCCTGGGTCCTTTGCCTCAA
GCTCTTTATAATGGTGAACCCTTTAAACATGAAGAGATGAATATTAAAGAACTAAAAATG
GCTGTTCTTCAAAGAATGATGGATGCATCTGTATATTTACAAAGAGAAGTTTTTTTGGGC
ACATTAAATGATCGCACGAATGCAATTGATTTTCTAATGGATAGGAATAATGTTGTACCC
CGTATAAATACTTTGATTTTGCGTACTAACCAGCAGTACCTCAATTTAATATCTACATCA
GTAACTGCTGATGTTGAAGATTTCTCTACTTTCTTTTTCTTGGATTCACAAGATAAGAGT
GCTGTAATTGCAAAGAACATGTATTATTTAACCCAAGACGATGAGAGTATAATTTCTGCA
GTCACTCTCTGGATTATTGCAGATTTTGATAAGCCTTCTGGGAGAAAACTTCTTTTTAAT
GCATTAAAGCACATGAAAACAAGTGTTCATAGTCGGTTGGGGATTATTTATAATCCTACA
TCAAAAATAAATGAAGAGAACACAGCTATTTCTAGAGGGATTTTGGCAGCTTTTCTTACA
CAGAAGAACATGTTTTTGAGAAGCTTTCTTGGGCAACTGGCAAAGGAAGAAATTGCTACA
ACTATTTACTCTGGAGATAAAATTAAAACATTCCTTATTGAGGGGATGGATAAGAATGCT
TTTGAGAAAAAATATAATACTGTTGGAGTGAATATTTTTCGAACTCACCAGTTGTTCTGT
CAAGATGTACTTAAATTACGTCCTGGAGAAATGGGTATTGTCAGCAATGGGAGATTCTTA
GGACCTTTAGATGAAGATTTTTATGCAGAAGATTTTTACTTGTTGGAAAAGATAACATTT
AGTAATTTAGGAGAGAAAATTAAAGGCATTGTTGAAAATATGGGAATCAACGCAAATAAC
ATGAGTGACTTTATTATGAAAGTTGATGCCCTTATGTCCTCTGTGCCTAAGCGTGCATCT
CGATATGATGTCACATTTCTTAGGGAGAATCACAGTGTTATAAAGACGAATCCTCAAGAG
AATGATATGTTCTTCAATGTCATTGCTATTGTTGATCCATTAACAAGAGAAGCACAGAAA
ATGGCACAGTTGTTGGTTGTACTTGGCAAGATTATCAACCTGAAGATAAAGTTGTTCATG
AACTGTAGGGGCAGGCTTTCAGAAGCCCCTTTAGAAAGCTTTTACCGTTTTGTTCTGGAA
CCAGAACTGATGTCAGGGGCTAATGACGTTTCTTCTCTTGGACCAGTGGCAAAATTTTTG
GATATTCCTGAATCACCCCTCCTAATCCTCAACATGATTACTCCAGAAGGCTGGTTGGTT
GAAACAGTGCACAGCAACTGTGACCTTGATAATATTCACTTAAAGGATACTGAGAAAACT
GTTACAGCAGAATATGAACTAGAATACTTACTACTGGAAGGACAATGCTTTGATAAAGTG
ACAGAACAGCCTCCTCGGGGTCTGCAGTTCACACTAGGCACAAAAAATAAACCTGCTGTG
GTTGATACAATAGTGATGGCACATCATGGGTATTTTCAATTAAAAGCAAACCCAGGTGCT
TGGATACTGAGGTTACACCAAGGAAAATCTGAAGATATTTATCAAATAGTTGGGCATGAA
GGAACTGACTCTCAAGCAGACCTAGAAGATATCATTGTTGTATTAAACAGCTTCAAAAGC
AAGATACTCAAAGTAAAAGTGAAAAAAGAAACAGACAAAATTAAGGAAGATATCCTTACC
GATGAAGATGAAAAAACAAAAGGACTGTGGGATTCCATTAAAAGTTTCACAGTAAGCTTG
CATAAAGAAAACAAAAAGGAAAAAGATGTCCTAAACATTTTTTCAGTTGCTTCTGGTCAT
TTATATGAACGTTTTTTAAGAATTATGATGCTTTCTGTTTTGCGTAACACCAAAACACCA
GTGAAATTCTGGTTGCTAAAAAATTATCTCTCACCGACATTTAAAGAAGTAATTCCTCAC
ATGGCTAAAGAGTATGGATTCCGATATGAACTAGTTCAATATAGGTGGCCCCGTTGGCTT
CGTCAACAGACTGAAAGACAGAGGATTATTTGGGGTTACAAAATTCTTTTCCTTGATGTT
CTTTTCCCACTAGCAGTGGACAAAATCATTTTTGTTGATGCTGACCAGATTGTGAGACAT
GATCTAAAAGAACTTCGAGATTTCGATCTGGATGGAGCTCCTTATGGGTATACTCCATTT
TGTGATAGCCGCAGGGAAATGGATGGATATCGTTTCTGGAAAACAGGATACTGGGCATCA
CATCTTTTAAGACGGAAATACCATATCAGTGCTTTATATGTAGTGGATCTCAAGAAGTTC
AGGAGAATTGGAGCAGGTGACAGGCTCAGGAGCCAGTATCAAGCTCTCAGTCAAGATCCA
AACAGTCTTTCAAACCTAGATCAGGATCTCCCCAATAATATGATTTACCAAGTCGCCATT
AAGTCTCTTCCTCAAGACTGGCTGTGGTGTGAAACCTGGTGTGATGATGAATCCAAACAA
AGAGCCAAAACAATTGATCTGTGCAATAATCCCAAAACAAAAGAATCCAAACTAAAAGCT
GCTGCCAGAATTGTCCCAGAATGGGTGGAGTATGATGCTGAGATAAGACAACTATTAGAT
CATCTTGAAAACAAGAAGCAAGATACAATTTTGACACATGATGAACTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1516 |
| Molecular Weight
| 174717.7 |
| Theoretical pI
| 6.88 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>UDP-glucose:glycoprotein glucosyltransferase 2
MAPAKATNVVRLLLGSTALWLSQLGSGTVAASKSVTAHLAAKWPETPLLLEASEFMAEES
NEKFWQFLETVQELAIYKQTESDYSYYNLILKKAGQFLDNLHINLLKFAFSIRAYSPAIQ
MFQQIAADEPPPDGCNAFVVIHKKHTCKINEIKKLLKKAASRTRPYLFKGDHKFPTNKEN
LPVVILYAEMGTRTFSAFHKVLSEKAQNEEILYVLRHYIQKPSSRKMYLSGYGVELAIKS
TEYKALDDTQVKTVTNTTVEDETETNEVQGFLFGKLKEIYSDLRDNLTAFQKYLIESNKQ
MMPLKVWELQDLSFQAASQIMSAPVYDAIKLMKDISQNFPIKARSLTRIAVNQHMREEIK
ENQKDLQVRFKIQPGDARLFINGLRVDMDVYDAFSILDMLKLEGKMMNGLRNLGINGEDM
SKFLKLNSHIWEYTYVLDIRHSSIMWINDLENDDLYITWPTSCQKLLKPVFPGSVPSIRR
NFHNLVLFIDPAQEYTLDFIKLADVFYSHEVPLRIGFVFILNTDDEVDGANDAGVALWRA
FNYIAEEFDISEAFISIVHMYQKVKKDQNILTVDNVKSVLQNTFPHANIWDILGIHSKYD
EERKAGASFYKMTGLGPLPQALYNGEPFKHEEMNIKELKMAVLQRMMDASVYLQREVFLG
TLNDRTNAIDFLMDRNNVVPRINTLILRTNQQYLNLISTSVTADVEDFSTFFFLDSQDKS
AVIAKNMYYLTQDDESIISAVTLWIIADFDKPSGRKLLFNALKHMKTSVHSRLGIIYNPT
SKINEENTAISRGILAAFLTQKNMFLRSFLGQLAKEEIATAIYSGDKIKTFLIEGMDKNA
FEKKYNTVGVNIFRTHQLFCQDVLKLRPGEMGIVSNGRFLGPLDEDFYAEDFYLLEKITF
SNLGEKIKGIVENMGINANNMSDFIMKVDALMSSVPKRASRYDVTFLRENHSVIKTNPQE
NDMFFNVIAIVDPLTREAQKMAQLLVVLGKIINMKIKLFMNCRGRLSEAPLESFYRFVLE
PELMSGANDVSSLGPVAKFLDIPESPLLILNMITPEGWLVETVHSNCDLDNIHLKDTEKT
VTAEYELEYLLLEGQCFDKVTEQPPRGLQFTLGTKNKPAVVDTIVMAHHGYFQLKANPGA
WILRLHQGKSEDIYQIVGHEGTDSQADLEDIIVVLNSFKSKILKVKVKKETDKIKEDILT
DEDEKTKGLWDSIKSFTVSLHKENKKEKDVLNIFSVASGHLYERFLRIMMLSVLRNTKTP
VKFWLLKNYLSPTFKEVIPHMAKEYGFRYELVQYRWPRWLRQQTERQRIIWGYKILFLDV
LFPLAVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWAS
HLLRRKYHISALYVVDLKKFRRIGAGDRLRSQYQALSQDPNSLSNLDQDLPNNMIYQVAI
KSLPQDWLWCETWCDDESKQRAKTIDLCNNPKTKESKLKAAARIVPEWVEYDAEIRQLLD
HLENKKQDTILTHDEL
|
| External Links |
|---|
| GenBank ID Protein
| 11346464 |
| UniProtKB/Swiss-Prot ID
| Q9NYU1 |
| UniProtKB/Swiss-Prot Entry Name
| UGGG2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF227906 |
| GeneCard ID
| UGGT2 |
| GenAtlas ID
| UGGT2 |
| HGNC ID
| HGNC:15664 |
| References |
|---|
| General References
| Not Available |