| Identification |
|---|
| HMDB Protein ID
| CDBP02606 |
| Secondary Accession Numbers
| Not Available |
| Name
| Methionyl-tRNA formyltransferase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- MtFMT
|
| Gene Name
| MTFMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in methionyl-tRNA formyltransferase activity |
| Specific Function
| Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).
|
| GO Classification
|
| Biological Process |
| translational initiation |
| Cellular Component |
| mitochondrion |
| Function |
| catalytic activity |
| transferase activity |
| glycine hydroxymethyltransferase activity |
| hydroxymethyl-, formyl- and related transferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| methionyl-trna formyltransferase activity |
| Molecular Function |
| methyltransferase activity |
| methionyl-tRNA formyltransferase activity |
| Process |
| macromolecule biosynthetic process |
| cellular macromolecule biosynthetic process |
| translation |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Methionine Metabolism |    |  | | Folate Metabolism |    |  | | One carbon pool by folate | Not Available | | | Aminoacyl-tRNA biosynthesis | Not Available |  | | Methotrexate Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q22.31 |
| SNPs
| MTFMT |
| Gene Sequence
|
>1170 bp
ATGAGGGTGTTGGTGCGGCGCTGTTGGGGTCCTCCGCTGGCTCATGGCGCCAGGCGTGGG
AGGCCGAGTCCCCAGTGGCGAGCACTGGCCCGACTCGGCTGGGAGGACTGCCGGGACTCC
AGAGTCCGCGAGAAGCCTCCCTGGCGGGTGCTCTTCTTCGGCACGGACCAGTTCGCCCGC
GAGGCGCTGCGGGCGCTGCACGCCGCCAGGGAAAACAAAGAAGAAGAGTTAATCGACAAA
CTGGAGGTGGTCACAATGCCTTCCCCATCACCAAAAGGACTGCCAGTGAAGCAATATGCT
GTGCAGTCTCAGCTTCCCGTATATGAGTGGCCGGATGTGGGATCTGGAGAATATGATGTT
GGAGTAGTGGCTTCGTTTGGCCGACTTTTGAATGAGGCTCTTATTCTTAAATTTCCCTAT
GGCATATTGAATGTTCATCCCAGTTGCCTCCCGAGATGGCGTGGCCCAGCCCCTGTAATC
CATACAGTGCTTCACGGAGACACAGTTACTGGAGTAACAATTATGCAAATTAGACCTAAA
AGGTTTGATGTAGGCCCAATTCTCAAACAAGAAACTGTTCCTGTGCCACCCAAGAGCACT
GCAAAGGAATTGGAAGCAGTGTTGTCAAGACTGGGTGCCAACATGCTCATTTCAGTTTTG
AAAAATTTGCCTGAAAGTCTGAGCAATGGAAGGCAGCAGCCAATGGAGGGGGCGACTTAC
GCCCCTAAGATTTCTGCTGGTACCAGTTGTATAAAATGGGAGGAACAAACTTCAGAACAA
ATATTCAGACTTTACCGTGCCATTGGAAATATAATTCCGTTGCAGACGCTCTGGATGGCG
AATACCATTAAACTTCTGGATTTGGTAGAAGTTAACAGTTCAGTCCTTGCTGATCCAAAA
TTAACGGGACAGGCTCTTATTCCAGGATCAGTAATATACCACAAACAGTCACAAATACTA
TTGGTTTATTGCAAGGATGGTTGGATTGGTGTTCGATCAGTGATGCTCAAGAAATCACTA
ACAGCTACTGACTTCTACAATGGATATTTGCACCCCTGGTACCAGAAAAATTCCCAAGCT
CAACCAAGCCAATGCAGATTTCAGACTCTCAGACTTCCAACAAAGAAGAAGCAGAAAAAA
ACTGTTGCTATGCAACAATGCATTGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 389 |
| Molecular Weight
| 43831.73 |
| Theoretical pI
| 9.663 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Methionyl-tRNA formyltransferase, mitochondrial
MRVLVRRCWGPPLAHGARRGRPSPQWRALARLGWEDCRDSRVREKPPWRVLFFGTDQFAR
EALRALHAARENKEEELIDKLEVVTMPSPSPKGLPVKQYAVQSQLPVYEWPDVGSGEYDV
GVVASFGRLLNEALILKFPYGILNVHPSCLPRWRGPAPVIHTVLHGDTVTGVTIMQIRPK
RFDVGPILKQETVPVPPKSTAKELEAVLSRLGANMLISVLKNLPESLSNGRQQPMEGATY
APKISAGTSCIKWEEQTSEQIFRLYRAIGNIIPLQTLWMANTIKLLDLVEVNSSVLADPK
LTGQALIPGSVIYHKQSQILLVYCKDGWIGVRSVMLKKSLTATDFYNGYLHPWYQKNSQA
QPSQCRFQTLRLPTKKKQKKTVAMQQCIE
|
| External Links |
|---|
| GenBank ID Protein
| 164663775 |
| UniProtKB/Swiss-Prot ID
| Q96DP5 |
| UniProtKB/Swiss-Prot Entry Name
| FMT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_139242.3 |
| GeneCard ID
| MTFMT |
| GenAtlas ID
| MTFMT |
| HGNC ID
| HGNC:29666 |
| References |
|---|
| General References
| Not Available |