| Identification |
|---|
| HMDB Protein ID
| CDBP02593 |
| Secondary Accession Numbers
| Not Available |
| Name
| Di-N-acetylchitobiase |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| CTBS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chitinase activity |
| Specific Function
| Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing o-glycosyl compounds |
| chitinase activity |
| Process |
| primary metabolic process |
| carbohydrate metabolic process |
| polysaccharide catabolic process |
| aminoglycan catabolic process |
| chitin catabolic process |
| polysaccharide metabolic process |
| metabolic process |
|
| Cellular Location
|
- Lysosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p22 |
| SNPs
| CTBS |
| Gene Sequence
|
>1158 bp
ATGTCCCGGCCGCAGCTTCGACGCTGGCGCCTCGTCTCTAGCCCGCCGAGCGGCGTCCCG
GGTCTAGCGCTGCTGGCGCTGCTGGCGCTGCTGGCGCTGCGGCTCGCGGCCGGGACCGAC
TGCCCATGCCCGGAGCCTGAGCTCTGCCGCCCGATTCGCCACCATCCAGATTTCGAGGTC
TTTGTGTTTGATGTTGGACAGAAAACTTGGAAATCTTATGATTGGTCACAGATTACAACT
GTGGCAACATTTGGAAAATATGACTCAGAACTTATGTGCTACGCTCATTCAAAAGGAGCC
AGAGTAGTACTTAAAGGAGATGTATCCTTAAAGGATATCATTGATCCTGCTTTCAGAGCA
TCCTGGATAGCTCAAAAACTTAATTTGGCCAAAACACAATATATGGATGGAATTAATATA
GATATAGAGCAAGAAGTTAATTGTTTATCACCTGAATATGATGCATTAACTGCTTTAGTC
AAAGAAACTACAGACTCTTTCCATCGTGAAATTGAGGGATCACAGGTAACCTTTGATGTA
GCTTGGTCTCCAAAGAACATAGACAGAAGATGCTATAATTATACTGGAATCGCAGATGCT
TGTGACTTCCTCTTTGTGATGTCTTATGATGAACAAAGTCAGATCTGGTCAGAATGTATT
GCAGCAGCCAATGCTCCCTATAATCAGACATTAACTGGATATAATGACTACATCAAGATG
AGCATTAATCCTAAGAAACTTGTAATGGGTGTTCCTTGGTATGGTTATGATTATACCTGC
CTGAATCTGTCTGAGGATCATGTTTGTACCATTGCAAAAGTCCCTTTCCGGGGGGCTCCT
TGTAGTGACGCTGCAGGACGTCAGGTGCCCTACAAAACGATCATGAAGCAAATAAATAGT
TCTATTTCTGGAAACCTATGGGATAAAGATCAGCGGGCTCCTTATTATAACTATAAAGAT
CCTGCTGGCCACTTTCATCAAGTATGGTATGATAACCCTCAGAGTATTTCTTTAAAGGCA
ACATATATACAAAACTATCGCTTACGGGGCATTGGCATGTGGAATGCAAACTGTCTTGAC
TACTCTGGAGATGCTGTAGCCAAACAGCAAACTGAAGAAATGTGGGAAGTCTTAAAGCCA
AAGCTGTTACAGAGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 385 |
| Molecular Weight
| 43759.4 |
| Theoretical pI
| 6.61 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Di-N-acetylchitobiase
MSRPQLRRWRLVSSPPSGVPGLALLALLALLALRLAAGTDCPCPEPELCRPIRHHPDFEV
FVFDVGQKTWKSYDWSQITTVATFGKYDSELMCYAHSKGARVVLKGDVSLKDIIDPAFRA
SWIAQKLNLAKTQYMDGINIDIEQEVNCLSPEYDALTALVKETTDSFHREIEGSQVTFDV
AWSPKNIDRRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYNDYIKM
SINPKKLVMGVPWYGYDYTCLNLSEDHVCTIAKVPFRGAPCSDAAGRQVPYKTIMKQINS
SISGNLWDKDQRAPYYNYKDPAGHFHQVWYDNPQSISLKATYIQNYRLRGIGMWNANCLD
YSGDAVAKQQTEEMWEVLKPKLLQR
|
| External Links |
|---|
| GenBank ID Protein
| 3603439 |
| UniProtKB/Swiss-Prot ID
| Q01459 |
| UniProtKB/Swiss-Prot Entry Name
| DIAC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF085706 |
| GeneCard ID
| CTBS |
| GenAtlas ID
| CTBS |
| HGNC ID
| HGNC:2496 |
| References |
|---|
| General References
| Not Available |