| Identification |
|---|
| HMDB Protein ID
| CDBP02515 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sedoheptulokinase |
| Description
| Not Available |
| Synonyms
|
- Carbohydrate kinase-like protein
- SHK
|
| Gene Name
| SHPK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphotransferase activity, alcohol group as acceptor |
| Specific Function
| Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity).
|
| GO Classification
|
| Biological Process |
| pentose-phosphate shunt, non-oxidative branch |
| regulation of inflammatory response |
| cellular response to lipopolysaccharide |
| cellular response to interleukin-13 |
| cellular response to interleukin-4 |
| regulation of macrophage activation |
| Cellular Component |
| cytoplasm |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| phosphotransferase activity, alcohol group as acceptor |
| Molecular Function |
| ATP binding |
| sedoheptulokinase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
|
| Cellular Location
|
- Cytoplasm (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Inositol Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p13 |
| SNPs
| SHPK |
| Gene Sequence
|
>1437 bp
ATGGCTGCGCGGCCGATCACCCTCGGCATTGACCTGGGCACCACATCTGTGAAGGCAGCT
CTGCTGAGGGCCGCGCCCGACGACCCATCCGGGTTCGCAGTGCTGGCGAGCTGTGCCCGT
GCTGCGCGGGCAGAGGCGGCGGTCGAGAGCGCGGTGGCCGGGCCCCAGGGGCGGGAGCAG
GATGTGAGTAGAATCCTCCAAGCCCTACACGAGTGCCTTGCTGCCCTTCCCCGACCCCAG
CTCCGGAGCGTCGTGGGCATCGGGGTGTCGGGCCAGATGCATGGAGTCGTGTTTTGGAAA
ACAGGCCAAGGCTGTGAATGGACAGAGGGAGGGATTACCCCGGTGTTCGAGCCCCGAGCT
GTTAGCCACCTGGTCACGTGGCAGGATGGCCGATGTAGCAGCGAATTCCTGGCCTCTCTG
CCCCAGCCGAAGTCTCATCTCAGTGTGGCCACGGGCTTCGGCTGTGCAACCATCTTCTGG
CTTTTGAAATATCGCCCAGAGTTCCTGAAGTCCTACGACGCAGCCGGTACCATCCACGAC
TATGTGGTTGCCATGCTGTGTGGCTTGCCAAGACCTCTGATGTCCGACCAGAATGCTGCC
AGCTGGGGCTATTTCAACACGCAGAGCCAAAGCTGGAACGTAGAGACACTGAGGAGCTCG
GGTTTTCCTGTCCACCTGCTCCCAGACATCGCCGAGCCTGGCAGTGTGGCGGGCAGAACT
TCCCACATGTGGTTTGAAATCCCAAAGGGGACGCAGGTGGGAGTGGCCTTGGGTGATTTA
CAGGCCTCTGTCTATTCCTGCATGGCCCAGAGGACAGATGCAGTTCTCAACATCAGCACC
TCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCT
ACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCA
CTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGAT
CTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAG
CAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGAC
CAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGG
GCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAG
GAGTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTG
AAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCA
GCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGACACCTCAACCAGAAGGAATCTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 478 |
| Molecular Weight
| 51504.425 |
| Theoretical pI
| 6.836 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sedoheptulokinase
MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQGREQ
DVSRILQALHECLAALPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRA
VSHLVTWQDGRCSSEFLASLPQPKSHLSVATGFGCATIFWLLKYRPEFLKSYDAAGTIHD
YVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGSVAGRT
SHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSGFQPAQTPDP
TAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQ
QRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQ
DWGVERVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQKES
|
| External Links |
|---|
| GenBank ID Protein
| 74315356 |
| UniProtKB/Swiss-Prot ID
| Q9UHJ6 |
| UniProtKB/Swiss-Prot Entry Name
| SHPK_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_013276.2 |
| GeneCard ID
| SHPK |
| GenAtlas ID
| SHPK |
| HGNC ID
| HGNC:1492 |
| References |
|---|
| General References
| Not Available |