| Identification |
|---|
| HMDB Protein ID
| CDBP02470 |
| Secondary Accession Numbers
| Not Available |
| Name
| Retinol dehydrogenase 10 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| RDH10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.
|
| GO Classification
|
| Biological Process |
| neural crest cell development |
| bud elongation involved in lung branching |
| ear development |
| gonad development |
| primary lung bud formation |
| retinoic acid biosynthetic process |
| retinol metabolic process |
| in utero embryonic development |
| nose development |
| retinal metabolic process |
| metanephros development |
| visual perception |
| embryonic viscerocranium morphogenesis |
| embryonic camera-type eye development |
| embryonic forelimb morphogenesis |
| Cellular Component |
| endoplasmic reticulum membrane |
| cytoplasm |
| integral to membrane |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| retinol dehydrogenase activity |
| NADP-retinol dehydrogenase activity |
| nucleotide binding |
| Process |
| oxidation reduction |
| metabolic process |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Microsome membrane
- Single-pass membrane protein (Potential)
- Single-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q21.11 |
| SNPs
| RDH10 |
| Gene Sequence
|
>1026 bp
ATGAACATCGTGGTGGAGTTCTTCGTGGTCACTTTCAAAGTGCTCTGGGCGTTCGTGCTG
GCCGCGGCGCGCTGGCTGGTGCGGCCCAAGGAGAAGAGCGTGGCGGGCCAGGTGTGCCTC
ATCACCGGCGCCGGCAGCGGCCTGGGCCGCCTCTTCGCGCTGGAGTTCGCCCGGCGTCGG
GCGCTGCTGGTGCTGTGGGACATCAACACGCAAAGCAACGAGGAGACGGCTGGCATGGTG
CGCCACATCTACCGCGACCTGGAGGCGGCCGACGCCGCTGCGCTGCAAGCTGGGAATGGT
GAGGAAGAAATTCTGCCCCACTGTAACTTGCAGGTTTTTACCTACACCTGTGACGTGGGG
AAGAGGGAGAACGTCTACCTGACGGCTGAAAGAGTCCGCAAGGAGGTTGGCGAAGTCTCA
GTCCTGGTCAATAATGCTGGTGTGGTCTCTGGGCATCACCTTCTGGAATGTCCTGATGAG
CTCATTGAGAGAACCATGATGGTCAATTGCCATGCACACTTCTGGACCACTAAGGCTTTT
CTTCCTACGATGCTGGAGATTAATCATGGTCATATTGTGACAGTTGCAAGTTCCTTGGGA
TTGTTCAGTACTGCCGGAGTTGAGGATTACTGTGCCAGTAAATTTGGAGTTGTGGGTTTT
CATGAATCCCTGAGCCATGAACTAAAGGCTGCTGAAAAGGATGGAATTAAAACAACCTTG
GTTTGCCCTTATCTTGTAGACACTGGCATGTTCAGAGGCTGCCGAATCAGGAAAGAAATT
GAGCCTTTTCTGCCACCTCTGAAGCCTGATTACTGTGTGAAGCAGGCCATGAAGGCCATC
CTCACTGACCAGCCCATGATCTGCACTCCCCGCCTCATGTACATCGTGACCTTCATGAAG
AGCATCCTACCATTTGAAGCAGTTGTGTGCATGTATCGGTTCCTAGGAGCGGACAAGTGT
ATGTACCCCTTTATTGCTCAAAGAAAGCAAGCCACAAACAATAATGAAGCAAAAAATGGA
ATCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 341 |
| Molecular Weight
| 38087.16 |
| Theoretical pI
| 7.4 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Retinol dehydrogenase 10
MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR
ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG
KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF
LPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTL
VCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMK
SILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI
|
| External Links |
|---|
| GenBank ID Protein
| 24817402 |
| UniProtKB/Swiss-Prot ID
| Q8IZV5 |
| UniProtKB/Swiss-Prot Entry Name
| RDH10_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF456765 |
| GeneCard ID
| RDH10 |
| GenAtlas ID
| RDH10 |
| HGNC ID
| HGNC:19975 |
| References |
|---|
| General References
| Not Available |