Cannabis Compound Database: Showing Protein Cytidine deaminase (CDBP02455)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP02455

Secondary Accession Numbers

Not Available

Name

Cytidine deaminase

Description

Not Available

Synonyms

Cytidine aminohydrolase

Gene Name

CDA

Protein Type

Enzyme

Biological Properties

General Function

Involved in zinc ion binding

Specific Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

GO Classification

Biological Process
cellular response to external biotic stimulus
cytosine metabolic process
negative regulation of nucleotide metabolic process
pyrimidine nucleoside salvage
response to cycloheximide
cell surface receptor signaling pathway
negative regulation of cell growth
protein homotetramerization
Cellular Component
cytosol
extracellular region
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
transition metal ion binding
zinc ion binding
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
cytidine deaminase activity
ion binding
cation binding
metal ion binding
binding
Molecular Function
nucleoside binding
metal ion binding
cytidine deaminase activity
zinc ion binding
protein homodimerization activity
Process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside metabolic process
pyrimidine nucleoside metabolic process
pyrimidine ribonucleoside metabolic process
cytidine metabolic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Cellular Location

Cytoplasmic

Pathways

Name	SMPDB/Pathwhiz	KEGG
Drug metabolism - other enzymes	Not Available
Pyrimidine Metabolism
Beta Ureidopropionase Deficiency		Not Available
UMP Synthase Deficiency (Orotic Aciduria)		Not Available
Dihydropyrimidinase Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

1p36.2-p35

SNPs

CDA

Gene Sequence

>441 bp
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACTCAGTGA

Protein Properties

Number of Residues

146

Molecular Weight

16184.545

Theoretical pI

6.921

Pfam Domain Function

dCMP_cyt_deam_1 (PF00383 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

External Links

GenBank ID Protein

598149

UniProtKB/Swiss-Prot ID

P32320

UniProtKB/Swiss-Prot Entry Name

CDD_HUMAN

PDB IDs