| Identification |
|---|
| HMDB Protein ID
| CDBP02454 |
| Secondary Accession Numbers
| Not Available |
| Name
| Prostaglandin E synthase 2 |
| Description
| Not Available |
| Synonyms
|
- Microsomal prostaglandin E synthase 2
- Prostaglandin E synthase 2 truncated form
- mPGES-2
|
| Gene Name
| PTGES2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
|
| GO Classification
|
| Biological Process |
| cell redox homeostasis |
| positive regulation of transcription, DNA-dependent |
| secretion |
| prostaglandin biosynthetic process |
| Cellular Component |
| cytosol |
| mitochondrion |
| perinuclear region of cytoplasm |
| nucleus |
| integral to membrane |
| Golgi membrane |
| Function |
| electron carrier activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| disulfide oxidoreductase activity |
| protein disulfide oxidoreductase activity |
| oxidoreductase activity |
| catalytic activity |
| Molecular Function |
| prostaglandin-E synthase activity |
| electron carrier activity |
| protein disulfide oxidoreductase activity |
| DNA binding |
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- perinuclear region
- Prostaglandin E synthase 2 truncated form:Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | prostaglandin biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.11 |
| SNPs
| PTGES2 |
| Gene Sequence
|
>1134 bp
ATGGACCCGGCTGCGCGGGTGGTGCGGGCGCTGTGGCCTGGTGGGTGCGCCTTGGCCTGG
AGGCTGGGAGGCCGCCCCCAGCCGCTGCTACCCACGCAGAGCCGGGCTGGCTTCGCGGGG
GCGGCGGGCGGCCCGAGCCCCGTGGCTGCAGCTCGTAAGGGGAGCCCGCGGCTGCTGGGA
GCTGCGGCGCTGGCCCTGGGGGGAGCCCTGGGGCTGTACCACACGGCGCGGTGGCACCTG
CGCGCCCAGGACCTCCACGCAGAGCGCTCAGCCGCGCAGCTCTCCCTGTCCAGCCGCCTG
CAGCTGACCCTGTACCAGTACAAGACGTGTCCCTTCTGCAGCAAGGTCCGAGCCTTCCTC
GACTTCCATGCCCTGCCCTACCAGGTGGTGGAGGTGAACCCTGTGCGCAGGGCTGAGATC
AAGTTCTCCTCCTACAGAAAGGTGCCCATCCTGGTGGCCCAGGAAGGAGAAAGCTCGCAA
CAACTAAATGACTCCTCTGTCATCATCAGCGCCCTCAAGACCTACCTGGTGTCGGGGCAG
CCCCTGGAAGAGATCATCACCTACTACCCAGCCATGAAGGCTGTGAACGAGCAGGGCAAG
GAGGTGACCGAGTTCGGCAATAAGTACTGGCTCATGCTCAACGAGAAGGAGGCCCAGCAA
GTGTATGGTGGGAAGGAGGCCAGGACGGAGGAGATGAAGTGGCGGCAGTGGGCGGACGAC
TGGCTGGTGCACCTGATCTCCCCCAATGTGTACCGCACGCCCACCGAGGCTCTGGCGTCC
TTTGACTACATTGTCCGCGAGGGCAAGTTCGGAGCCGTGGAGGGTGCCGTGGCCAAGTAC
ATGGGTGCAGCGGCCATGTACCTCATCAGCAAGCGACTCAAGAGCAGGCACCGCCTCCAG
GACAACGTGCGCGAGGACCTCTATGAGGCTGCTGACAAGTGGGTGGCTGCTGTGGGCAAG
GACCGGCCCTTCATGGGGGGCCAGAAGCCGAATCTCGCTGATTTGGCGGTGTATGGCGTG
CTGCGTGTGATGGAGGGGCTGGATGCATTCGATGACCTGATGCAGCACACGCACATCCAG
CCCTGGTACCTGCGGGTGGAGAGGGCCATCACCGAGGCCTCCCCAGCGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 377 |
| Molecular Weight
| 21337.205 |
| Theoretical pI
| 6.703 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostaglandin E synthase 2
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLG
AAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFL
DFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQ
PLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADD
WLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQ
DNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQ
PWYLRVERAITEASPAH
|
| External Links |
|---|
| GenBank ID Protein
| 10436397 |
| UniProtKB/Swiss-Prot ID
| Q9H7Z7 |
| UniProtKB/Swiss-Prot Entry Name
| PGES2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK024100 |
| GeneCard ID
| PTGES2 |
| GenAtlas ID
| PTGES2 |
| HGNC ID
| HGNC:17822 |
| References |
|---|
| General References
| Not Available |