| Identification |
|---|
| HMDB Protein ID
| CDBP02446 |
| Secondary Accession Numbers
| Not Available |
| Name
| Retinol dehydrogenase 11 |
| Description
| Not Available |
| Synonyms
|
- Androgen-regulated short-chain dehydrogenase/reductase 1
- HCV core-binding protein HCBP12
- Prostate short-chain dehydrogenase/reductase 1
- RalR1
- Retinal reductase 1
|
| Gene Name
| RDH11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| retinol metabolic process |
| steroid metabolic process |
| retinal metabolic process |
| adaptation of rhodopsin mediated signaling |
| Cellular Component |
| endoplasmic reticulum membrane |
| photoreceptor inner segment |
| integral to membrane |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| retinol dehydrogenase activity |
| NADP-retinol dehydrogenase activity |
| nucleotide binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Retinol Metabolism |    |  | | Vitamin A Deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q24.1 |
| SNPs
| RDH11 |
| Gene Sequence
|
>957 bp
ATGGTTGAGCTCATGTTCCCGCTGTTGCTCCTCCTTCTGCCCTTCCTTCTGTATATGGCT
GCGCCCCAAATCAGGAAAATGCTGTCCAGTGGGGTGTGTACATCAACTGTTCAGCTTCCT
GGGAAAGTAGTTGTGGTCACAGGAGCTAATACAGGTATCGGGAAGGAGACAGCCAAAGAG
CTGGCTCAGAGAGGAGCTCGAGTATATTTAGCTTGCCGGGATGTGGAAAAGGGGGAATTG
GTGGCCAAAGAGATCCAGACCACGACAGGGAACCAGCAGGTGTTGGTGCGGAAACTGGAC
CTGTCTGATACTAAGTCTATTCGAGCTTTTGCTAAGGGCTTCTTAGCTGAGGAAAAGCAC
CTCCACGTTTTGATCAACAATGCAGGAGTGATGATGTGTCCGTACTCGAAGACAGCAGAT
GGCTTTGAGATGCACATAGGAGTCAACCACTTGGGTCACTTCCTCCTAACCCATCTGCTG
CTAGAGAAACTAAAGGAATCAGCCCCATCAAGGATAGTAAATGTGTCTTCCCTCGCACAT
CACCTGGGAAGGATCCACTTCCATAACCTGCAGGGCGAGAAATTCTACAATGCAGGCCTG
GCCTACTGTCACAGCAAGCTAGCCAACATCCTCTTCACCCAGGAACTGGCCCGGAGACTA
AAAGGCTCTGGCGTTACGACGTATTCTGTACACCCTGGCACAGTCCAATCTGAACTGGTT
CGGCACTCATCTTTCATGAGATGGATGTGGTGGCTTTTCTCCTTTTTCATCAAGACTCCT
CAGCAGGGAGCCCAGACCAGCCTGCACTGTGCCTTAACAGAAGGTCTTGAGATTCTAAGT
GGGAATCATTTCAGTGACTGTCATGTGGCATGGGTCTCTGCCCAAGCTCGTAATGAGACT
ATAGCAAGGCGGCTGTGGGACGTCAGTTGTGACCTGCTGGGCCTCCCAATAGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 318 |
| Molecular Weight
| 35385.955 |
| Theoretical pI
| 8.826 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Retinol dehydrogenase 11
MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKE
LAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKH
LHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAH
HLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELV
RHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNET
IARRLWDVSCDLLGLPID
|
| External Links |
|---|
| GenBank ID Protein
| 4929633 |
| UniProtKB/Swiss-Prot ID
| Q8TC12 |
| UniProtKB/Swiss-Prot Entry Name
| RDH11_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF151840 |
| GeneCard ID
| RDH11 |
| GenAtlas ID
| RDH11 |
| HGNC ID
| HGNC:17964 |
| References |
|---|
| General References
| Not Available |