| Identification |
|---|
| HMDB Protein ID
| CDBP02444 |
| Secondary Accession Numbers
| Not Available |
| Name
| Retinol dehydrogenase 8 |
| Description
| Not Available |
| Synonyms
|
- Photoreceptor outer segment all-trans retinol dehydrogenase
|
| Gene Name
| RDH8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in estradiol 17-beta-dehydrogenase activity |
| Specific Function
| Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).
|
| GO Classification
|
| Biological Process |
| retinol metabolic process |
| steroid biosynthetic process |
| visual perception |
| response to stimulus |
| estrogen biosynthetic process |
| Cellular Component |
| cytoplasm |
| integral to plasma membrane |
| Component |
| cytoplasm |
| cell part |
| intracellular part |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| steroid dehydrogenase activity |
| steroid dehydrogenase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
| estradiol 17-beta-dehydrogenase activity |
| Molecular Function |
| retinol dehydrogenase activity |
| estradiol 17-beta-dehydrogenase activity |
| NADP-retinol dehydrogenase activity |
| nucleotide binding |
| Process |
| steroid biosynthetic process |
| estrogen biosynthetic process |
| metabolic process |
| primary metabolic process |
| oxidation reduction |
| lipid metabolic process |
| steroid metabolic process |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Retinol Metabolism |    |  | | Vitamin A Deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.2 |
| SNPs
| RDH8 |
| Gene Sequence
|
>936 bp
ATGGCCGCTGCACCCCGGACTGTGTTGATCTCCGGCTGCTCATCAGGAATTGGTCTGGAA
CTTGCAGTGCAACTGGCCCATGACCCCAAGAAGCGCTACCAGGTCGTGGCCACCATGAGG
GACCTGGGGAAGAAGGAGACACTGGAGGCAGCTGCTGGGGAGGCTCTGGGGCAGACCCTC
ACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATC
CAGGGAGAAGTGGACGTGCTGGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAG
GGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTTCGGAGCTGTCCGT
CTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATC
AGCAGTGTCATGGGCCTGCAGGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTC
GCCCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTTCAACATCTTCATC
TCCCTGGTGGAGCCAGGCCCCGTGGTCACCGAGTTTGAGGGGAAGCTTCTGGCGCAGGTT
TCTATGGCTGAGTTCCCAGGCACTGACCCTGAGACCCTGCACTACTTCCGGGACCTCTAT
CTCCCAGCCTCCAGGAAGCTGTTTTGCTCCGTGGGACAGAACCCACAGGACGTGGTTCAG
GCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACATCCGC
TACTCGCCGCTGACCACGCTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGCGAACG
ACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCTTCAATGTCTGTCC
TGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 311 |
| Molecular Weight
| 35804.24 |
| Theoretical pI
| 8.238 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Retinol dehydrogenase 8
MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTL
TVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVR
LVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFI
SLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQ
AIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLS
CGCLPTRVRPR
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9NYR8 |
| UniProtKB/Swiss-Prot Entry Name
| RDH8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF229845 |
| GeneCard ID
| RDH8 |
| GenAtlas ID
| RDH8 |
| HGNC ID
| HGNC:14423 |
| References |
|---|
| General References
| Not Available |