| Identification |
|---|
| HMDB Protein ID
| CDBP02437 |
| Secondary Accession Numbers
| Not Available |
| Name
| Testis anion transporter 1 |
| Description
| Not Available |
| Synonyms
|
- Anion exchange transporter
- Solute carrier family 26 member 8
|
| Gene Name
| SLC26A8 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transporter activity |
| Process |
| transmembrane transport |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21 |
| SNPs
| SLC26A8 |
| Gene Sequence
|
>2913 bp
ATGGCACAACTAGAGAGGAGCGCCATCTCTGGCTTCAGCTCTAAGTCCAGGCGAAACTCA
TTCGCATATGATGTTAAGCGTGAAGTATACAATGAGGAGACCTTTCAACAGGAACACAAA
AGGAAGGCCTCCTCTTCTGGGAACATGAACATCAACATCACCACCTTCAGACACCACGTC
CAGTGCCGCTGCTCATGGCACAGGTTCCTACGATGCATGCTTACAATCTTTCCCTTCCTA
GAATGGATGTGTATGTATCGATTAAAGGATTGGCTTCTGGGAGACTTACTTGCTGGTATA
AGTGTTGGCCTTGTGCAAGTTCCCCAAGGCCTGACACTTAGTTTGCTGGCAAGGCAACTG
ATTCCTCCTCTCAACATCGCTTATGCAGCTTTCTGTTCTTCGGTAATCTATGTAATTTTT
GGATCGTGTCATCAAATGTCCGTTGGTTCCTTCTTCCTGGTGAGTGCTCTGCTGATCAAC
GTTCTGAAAGTGAGCCCATTCGACAACGGTCAACTGGTCATGGGATCTTTCGTCAAGAAT
GAGTTTTCGGCCCCCTCCTACCTTATGGGCTATAATAAATCCTTGAGTGTGGTGGCAACC
ACAACTTTTCTGACTGGGATTATTCAGCTAATAATGGGCGTATTGGGTTTGGGCTTCATT
GCCACTTACCTTCCGGAGTCTGCAATGAATGCTTACCTGGCTGCTGTGGCACTTCATATC
ATGCTGTCCCAGCTGACTTTCATCTTTGGGATTATGATTAGTTTCCATGCCGGTCCCATC
TCCTTCTTCTATGACATAATTAATTACTGTGTAGCTCTCCCAAAAGCGAATTCCACCAGC
ATTCTAGTATTTCTAACTGTTGTTGTTGCTCTGCGAATCAACAAATGTATCAGAATTTCT
TTCAATCAGTATCCCATTGAGTTTCCCATGGAATTATTTCTGATTATTGGCTTCACTGTG
ATTGCAAACAAGATAAGCATGGCCACAGAAACCAGCCAGACGCTTATTGACATGATTCCT
TATAGCTTTCTGCTTCCTGTAACACCAGATTTCAGCCTTCTTCCCAAGATAATTTTACAA
GCCTTCTCCTTATCTTTGGTGAGCTCCTTTCTGCTCATATTTCTGGGCAAGAAGATTGCC
AGTCTTCACAATTACAGTGTCAATTCCAACCAGGATTTAATAGCCATCGGCCTTTGCAAT
GTCGTCAGTTCATTTTTCAGATCTTGTGTGTTTACTGGTGCTATTGCTAGGACTATTATC
CAGGATAAATCTGGAGGAAGACAACAGTTTGCATCTCTGGTAGGCGCAGGTGTGATGCTG
CTCCTGATGGTGAAGATGGGACACTTTTTCTACACACTGCCAAATGCTGTGCTGGCTGGT
ATTATTCTGAGCAACGTCATTCCCTACCTTGAAACCATTTCTAACCTACCCAGCCTGTGG
AGGCAGGACCAATATGACTGTGCTCTTTGGATGATGACATTCTCATCTTCAATTTTCCTG
GGACTGGACATTGGACTAATTATCTCAGTAGTTTCTGCTTTCTTCATCACCACTGTTCGT
TCACACAGAGCTAAGATTCTTCTCCTGGGTCAAATCCCTAACACCAACATTTATAGAAGC
ATCAATGATTATCGGGAGATCATCACCATTCCTGGGGTGAAAATCTTCCAGTGCTGCTGC
TCAATTACATTTGTAAATGTTTACTACCTAAAGCATAAGCTGTTAAAAGAGGTTGATATG
GTAAAGGTGCCTCTTAAAGAAGAAGAAATTTTCAGCTTGTTTAATTCAAGTGACACCAAT
CTACAAGGAGGAAAGATTTGCAGGTGTTTCTGCAACTGTGATGATCTGGAGCCGCTGCCC
AGGATTCTTTACACAGAGCGATTTGAAAATAAACTGGATCCCGAAGCATCCTCCGTTAAC
CTGATTCACTGCTCACATTTTGAGAGCATGAACACAAGCCAAACTGCATCCGAAGACCAA
GTGCCATACACAGTATCGTCTGTGTCTCAGAAAAATCAAGGGCAACAGTATGAGGAGGTG
GAAGAAGTTTGGCTTCCTAATAACTCATCAAGAAACAGCTCACCAGGACTGCCTGATGTG
GCGGAAAGCCAGGGGAGGAGATCACTCATCCCTTACTCAGATGCGTCTCTACTGCCCAGT
GTCCACACCATCATCCTGGATTTCTCCATGGTACACTACGTGGATTCACGGGGGTTAGTC
GTATTAAGACAGATATGCAATGCCTTTCAAAACGCCAACATTTTGATACTCATTGCAGGG
TGTCACTCTTCCATAGTCAGGGCATTTGAGAGGAATGATTTCTTTGACGCTGGCATCACC
AAGACCCAGCTGTTCCTCAGCGTTCACGACGCCGTGCTGTTTGCCTTGTCAAGGAAGGTC
ATAGGCTCCTCCGAGTTAAGCATCGATGAATCCGAGACAGTGATACGGGAAACCTACTCA
GAAACAGACAAGAATGACAATTCAAGATATAAAATGAGCAGCAGTTTTCTAGGAAGCCAA
AAAAATGTAAGTCCAGGCTTCATCAAGATCCAACAGCCTGTAGAAGAGGAGTCGGAGTTG
GATTTGGAGCTGGAATCAGAACAAGAGGCTGGGCTGGGTCTGGACCTAGACCTGGATCGG
GAGCTGGAGCCTGAAATGGAGCCCAAGGCTGAGACCGAGACCAAGACCCAGACCGAGATG
GAGCCCCAGCCTGAGACTGAGCCTGAGATGGAGCCCAACCCCAAATCTAGGCCAAGAGCT
CACACTTTTCCTCAGCAGCGTTACTGGCCTATGTATCATCCGTCTATGGCTTCCACCCAG
TCTCAGACTCAGACTCGGACATGGTCAGTGGAGAGGAGACGCCATCCTATGGATTCATAC
TCACCAGAGGGCAACAGCAATGAAGATGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 970 |
| Molecular Weight
| 109004.5 |
| Theoretical pI
| 6.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["96-116", "120-140", "147-167", "203-223", "233-253", "271-291", "308-328", "356-376", "393-413", "430-450", "453-473", "498-518"]
|
| Protein Sequence
|
>Testis anion transporter 1
MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
QCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN
EFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHI
MLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRIS
FNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQ
AFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTII
QDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLW
RQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRS
INDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTN
LQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQ
VPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPS
VHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGIT
KTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQ
KNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEM
EPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSY
SPEGNSNEDV
|
| External Links |
|---|
| GenBank ID Protein
| 16588684 |
| UniProtKB/Swiss-Prot ID
| Q96RN1 |
| UniProtKB/Swiss-Prot Entry Name
| S26A8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF314959 |
| GeneCard ID
| SLC26A8 |
| GenAtlas ID
| SLC26A8 |
| HGNC ID
| HGNC:14468 |
| References |
|---|
| General References
| Not Available |