Identification
HMDB Protein ID CDBP02409
Secondary Accession Numbers Not Available
Name Thymidylate synthase
Description Not Available
Synonyms
  1. TS
  2. TSase
Gene Name TYMS
Protein Type Enzyme
Biological Properties
General Function Involved in thymidylate synthase activity
Specific Function Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
GO Classification
Biological Process
response to drug
response to glucocorticoid stimulus
response to organophosphorus
regulation of transcription involved in G1/S phase of mitotic cell cycle
cartilage development
pyrimidine nucleoside biosynthetic process
phosphatidylinositol-mediated signaling
dTTP biosynthetic process
aging
pyrimidine nucleobase metabolic process
organ regeneration
DNA repair
DNA replication
deoxyribonucleoside monophosphate biosynthetic process
dTMP biosynthetic process
dUMP metabolic process
developmental growth
immortalization of host cell by virus
intestinal epithelial cell maturation
Cellular Component
cytosol
mitochondrial matrix
nucleoplasm
mitochondrial inner membrane
Function
methyltransferase activity
catalytic activity
transferase activity
5,10-methylenetetrahydrofolate-dependent methyltransferase activity
thymidylate synthase activity
transferase activity, transferring one-carbon groups
Molecular Function
thymidylate synthase activity
cofactor binding
folic acid binding
nucleotide binding
Process
pyrimidine nucleotide biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine deoxyribonucleoside monophosphate biosynthetic process
dtmp biosynthetic process
pyrimidine nucleotide metabolic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 18
Locus 18p11.32
SNPs TYMS
Gene Sequence
>942 bp
ATGCCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCCCCCCGCCGCACAGGAGCGG
GACGCCGAGCCGCGTCCGCCGCACGGGGAGCTGCAGTACCTGGGGCAGATCCAACACATC
CTCCGCTGCGGCGTCAGGAAGGACGACCGCACGGGCACCGGCACCCTGTCGGTATTCGGC
ATGCAGGCGCGCTACAGCCTGAGAGATGAATTCCCTCTGCTGACAACCAAACGTGTGTTC
TGGAAGGGTGTTTTGGAGGAGTTGCTGTGGTTTATCAAGGGATCCACAAATGCTAAAGAG
CTGTCTTCCAAGGGAGTGAAAATCTGGGATGCCAATGGATCCCGAGACTTTTTGGACAGC
CTGGGATTCTCCACCAGAGAAGAAGGGGACTTGGGCCCAGTTTATGGCTTCCAGTGGAGG
CATTTTGGGGCAGAATACAGAGATATGGAATCAGATTATTCAGGACAGGGAGTTGACCAA
CTGCAAAGAGTGATTGACACCATCAAAACCAACCCTGACGACAGAAGAATCATCATGTGC
GCTTGGAATCCAAGAGATCTTCCTCTGATGGCGCTGCCTCCATGCCATGCCCTCTGCCAG
TTCTATGTGGTGAACAGTGAGCTGTCCTGCCAGCTGTACCAGAGATCGGGAGACATGGGC
CTCGGTGTGCCTTTCAACATCGCCAGCTACGCCCTGCTCACGTACATGATTGCGCACATC
ACGGGCCTGAAGCCAGGTGACTTTATACACACTTTGGGAGATGCACATATTTACCTGAAT
CACATCGAGCCACTGAAAATTCAGCTTCAGCGAGAACCCAGACCTTTCCCAAAGCTCAGG
ATTCTTCGAAAAGTTGAGAAAATTGATGACTTCAAAGCTGAAGACTTTCAGATTGAAGGG
TACAATCCGCATCCAACTATTAAAATGGAAATGGCTGTTTAG
Protein Properties
Number of Residues 313
Molecular Weight 35715.65
Theoretical pI 6.998
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Thymidylate synthase
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
GenBank ID Protein 37479
UniProtKB/Swiss-Prot ID P04818
UniProtKB/Swiss-Prot Entry Name TYSY_HUMAN
PDB IDs
GenBank Gene ID X02308
GeneCard ID TYMS
GenAtlas ID TYMS
HGNC ID HGNC:12441
References
General References Not Available