| Identification |
|---|
| HMDB Protein ID
| CDBP02382 |
| Secondary Accession Numbers
| Not Available |
| Name
| Vesicular glutamate transporter 1 |
| Description
| Not Available |
| Synonyms
|
- Brain-specific Na(+)-dependent inorganic phosphate cotransporter
- Solute carrier family 17 member 7
- VGluT1
|
| Gene Name
| SLC17A7 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
|
| GO Classification
|
| Biological Process |
| regulation of excitatory postsynaptic membrane potential |
| L-glutamate import |
| sequestering of neurotransmitter |
| synaptic transmission, glutamatergic |
| neurotransmitter secretion |
| glutamate secretion |
| long-term memory |
| Cellular Component |
| clathrin-sculpted glutamate transport vesicle membrane |
| presynaptic active zone |
| neuron projection |
| integral to membrane |
| synaptic vesicle membrane |
| plasma membrane |
| cell junction |
| excitatory synapse |
| Molecular Function |
| inorganic phosphate transmembrane transporter activity |
| sodium:inorganic phosphate symporter activity |
| sodium-dependent phosphate transmembrane transporter activity |
| L-glutamate transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Membrane
- Multi-pass membrane protein (Potential)
- secretory vesicle
- Cell junction
- synapse
- synaptosome
- synaptic vesicle membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Synaptic vesicle cycle | Not Available |  | | Retrograde endocannabinoid signaling | Not Available |  | | Glutamatergic synapse | Not Available |  | | Nicotine addiction | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13 |
| SNPs
| SLC17A7 |
| Gene Sequence
|
>1683 bp
ATGGAGTTCCGCCAGGAGGAGTTTCGGAAGCTAGCGGGTCGTGCTCTCGGGAAGCTGCAC
CGCCTTCTGGAGAAGCGGCAGGAAGGCGCGGAGACGCTGGAGCTGAGTGCGGATGGGCGC
CCGGTGACCACGCAGACCCGGGACCCGCCGGTGGTGGACTGCACCTGCTTCGGCCTCCCT
CGCCGCTACATTATCGCCATCATGAGTGGTCTGGGCTTCTGCATCAGCTTTGGCATCCGC
TGCAACCTGGGCGTGGCCATCGTCTCCATGGTCAATAACAGCACGACCCACCGCGGGGGC
CACGTGGTGGTGCAGAAAGCCCAGTTCAGCTGGGATCCAGAGACTGTCGGCCTCATACAC
GGCTCCTTTTTCTGGGGCTACATTGTCACTCAGATTCCAGGAGGATTTATCTGTCAAAAA
TTTGCAGCCAACAGAGTTTTCGGCTTTGCTATTGTGGCAACATCCACTCTAAACATGCTG
ATCCCCTCAGCTGCCCGCGTCCACTATGGCTGTGTCATCTTCGTGAGGATCCTGCAGGGG
TTGGTAGAGGGGGTCACATACCCCGCCTGCCATGGGATCTGGAGCAAATGGGCCCCACCC
TTAGAACGGAGTCGCCTGGCGACGACAGCCTTTTGTGGTTCCTATGCTGGGGCGGTGGTC
GCGATGCCCCTCGCCGGGGTCCTTGTGCAGTACTCAGGATGGAGCTCTGTTTTCTACGTC
TACGGCAGCTTCGGGATCTTCTGGTACCTGTTCTGGCTGCTCGTCTCCTACGAGTCCCCC
GCGCTGCACCCCAGCATCTCGGAGGAGGAGCGCAAGTACATCGAGGACGCCATCGGAGAG
AGCGCGAAACTCATGAACCCCCTCACGAAGTTTAGCACTCCCTGGCGGCGCTTCTTCACG
TCTATGCCAGTCTATGCCATCATCGTGGCCAACTTCTGCCGCAGCTGGACGTTCTACCTG
CTGCTCATCTCCCAGCCCGCCTACTTCGAAGAAGTGTTCGGCTTCGAGATCAGCAAGGTA
GGCCTGGTGTCCGCGCTGCCCCACCTGGTCATGACCATCATCGTGCCCATCGGCGGCCAG
ATCGCGGACTTCCTGCGGAGCCGCCGCATCATGTCCACCACCAACGTGCGCAAGTTGATG
AACTGCGGAGGCTTCGGCATGGAAGCCACGCTGCTGTTGGTGGTCGGCTACTCGCACTCC
AAGGGCGTGGCCATCTCCTTCCTGGTCCTAGCCGTGGGCTTCAGCGGCTTCGCCATCTCT
GGGTTCAACGTGAACCACCTGGACATAGCCCCGCGCTACGCCAGCATCCTCATGGGCATC
TCCAACGGCGTGGGCACACTGTCGGGCATGGTGTGCCCCATCATCGTGGGGGCCATGACT
AAGCACAAGACTCGGGAGGAGTGGCAGTACGTGTTCCTAATTGCCTCCCTGGTGCACTAT
GGAGGTGTCATCTTCTACGGGGTCTTTGCTTCTGGAGAGAAGCAGCCGTGGGCAGAGCCT
GAGGAGATGAGCGAGGAGAAGTGTGGCTTCGTTGGCCATGACCAGCTGGCTGGCAGTGAC
GACAGCGAAATGGAGGATGAGGCTGAGCCCCCGGGGGCACCCCCTGCACCCCCGCCCTCC
TATGGGGCCACACACAGCACATTTCAGCCCCCCAGGCCCCCACCCCCTGTCCGGGACTAC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 560 |
| Molecular Weight
| 61612.845 |
| Theoretical pI
| 7.475 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Vesicular glutamate transporter 1
MEFRQEEFRKLAGRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDPPVVDCTCFGLP
RRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIH
GSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQG
LVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYV
YGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPLTKFSTPWRRFFT
SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQ
IADFLRSRRIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAIS
GFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHY
GGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAEPPGAPPAPPPS
YGATHSTFQPPRPPPPVRDY
|
| External Links |
|---|
| GenBank ID Protein
| 7328925 |
| UniProtKB/Swiss-Prot ID
| Q9P2U7 |
| UniProtKB/Swiss-Prot Entry Name
| VGLU1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB032436 |
| GeneCard ID
| SLC17A7 |
| GenAtlas ID
| SLC17A7 |
| HGNC ID
| HGNC:16704 |
| References |
|---|
| General References
| Not Available |