Identification
HMDB Protein ID CDBP02382
Secondary Accession Numbers Not Available
Name Vesicular glutamate transporter 1
Description Not Available
Synonyms
  1. Brain-specific Na(+)-dependent inorganic phosphate cotransporter
  2. Solute carrier family 17 member 7
  3. VGluT1
Gene Name SLC17A7
Protein Type Transporter
Biological Properties
General Function Involved in transmembrane transport
Specific Function Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
GO Classification
Biological Process
regulation of excitatory postsynaptic membrane potential
L-glutamate import
sequestering of neurotransmitter
synaptic transmission, glutamatergic
neurotransmitter secretion
glutamate secretion
long-term memory
Cellular Component
clathrin-sculpted glutamate transport vesicle membrane
presynaptic active zone
neuron projection
integral to membrane
synaptic vesicle membrane
plasma membrane
cell junction
excitatory synapse
Molecular Function
inorganic phosphate transmembrane transporter activity
sodium:inorganic phosphate symporter activity
sodium-dependent phosphate transmembrane transporter activity
L-glutamate transmembrane transporter activity
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Cytoplasmic vesicle
  2. Membrane
  3. Multi-pass membrane protein (Potential)
  4. secretory vesicle
  5. Cell junction
  6. synapse
  7. synaptosome
  8. synaptic vesicle membrane
Pathways
Gene Properties
Chromosome Location 19
Locus 19q13
SNPs SLC17A7
Gene Sequence
>1683 bp
ATGGAGTTCCGCCAGGAGGAGTTTCGGAAGCTAGCGGGTCGTGCTCTCGGGAAGCTGCAC
CGCCTTCTGGAGAAGCGGCAGGAAGGCGCGGAGACGCTGGAGCTGAGTGCGGATGGGCGC
CCGGTGACCACGCAGACCCGGGACCCGCCGGTGGTGGACTGCACCTGCTTCGGCCTCCCT
CGCCGCTACATTATCGCCATCATGAGTGGTCTGGGCTTCTGCATCAGCTTTGGCATCCGC
TGCAACCTGGGCGTGGCCATCGTCTCCATGGTCAATAACAGCACGACCCACCGCGGGGGC
CACGTGGTGGTGCAGAAAGCCCAGTTCAGCTGGGATCCAGAGACTGTCGGCCTCATACAC
GGCTCCTTTTTCTGGGGCTACATTGTCACTCAGATTCCAGGAGGATTTATCTGTCAAAAA
TTTGCAGCCAACAGAGTTTTCGGCTTTGCTATTGTGGCAACATCCACTCTAAACATGCTG
ATCCCCTCAGCTGCCCGCGTCCACTATGGCTGTGTCATCTTCGTGAGGATCCTGCAGGGG
TTGGTAGAGGGGGTCACATACCCCGCCTGCCATGGGATCTGGAGCAAATGGGCCCCACCC
TTAGAACGGAGTCGCCTGGCGACGACAGCCTTTTGTGGTTCCTATGCTGGGGCGGTGGTC
GCGATGCCCCTCGCCGGGGTCCTTGTGCAGTACTCAGGATGGAGCTCTGTTTTCTACGTC
TACGGCAGCTTCGGGATCTTCTGGTACCTGTTCTGGCTGCTCGTCTCCTACGAGTCCCCC
GCGCTGCACCCCAGCATCTCGGAGGAGGAGCGCAAGTACATCGAGGACGCCATCGGAGAG
AGCGCGAAACTCATGAACCCCCTCACGAAGTTTAGCACTCCCTGGCGGCGCTTCTTCACG
TCTATGCCAGTCTATGCCATCATCGTGGCCAACTTCTGCCGCAGCTGGACGTTCTACCTG
CTGCTCATCTCCCAGCCCGCCTACTTCGAAGAAGTGTTCGGCTTCGAGATCAGCAAGGTA
GGCCTGGTGTCCGCGCTGCCCCACCTGGTCATGACCATCATCGTGCCCATCGGCGGCCAG
ATCGCGGACTTCCTGCGGAGCCGCCGCATCATGTCCACCACCAACGTGCGCAAGTTGATG
AACTGCGGAGGCTTCGGCATGGAAGCCACGCTGCTGTTGGTGGTCGGCTACTCGCACTCC
AAGGGCGTGGCCATCTCCTTCCTGGTCCTAGCCGTGGGCTTCAGCGGCTTCGCCATCTCT
GGGTTCAACGTGAACCACCTGGACATAGCCCCGCGCTACGCCAGCATCCTCATGGGCATC
TCCAACGGCGTGGGCACACTGTCGGGCATGGTGTGCCCCATCATCGTGGGGGCCATGACT
AAGCACAAGACTCGGGAGGAGTGGCAGTACGTGTTCCTAATTGCCTCCCTGGTGCACTAT
GGAGGTGTCATCTTCTACGGGGTCTTTGCTTCTGGAGAGAAGCAGCCGTGGGCAGAGCCT
GAGGAGATGAGCGAGGAGAAGTGTGGCTTCGTTGGCCATGACCAGCTGGCTGGCAGTGAC
GACAGCGAAATGGAGGATGAGGCTGAGCCCCCGGGGGCACCCCCTGCACCCCCGCCCTCC
TATGGGGCCACACACAGCACATTTCAGCCCCCCAGGCCCCCACCCCCTGTCCGGGACTAC
TGA
Protein Properties
Number of Residues 560
Molecular Weight 61612.845
Theoretical pI 7.475
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Vesicular glutamate transporter 1
MEFRQEEFRKLAGRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDPPVVDCTCFGLP
RRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIH
GSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQG
LVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYV
YGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPLTKFSTPWRRFFT
SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQ
IADFLRSRRIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAIS
GFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHY
GGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAEPPGAPPAPPPS
YGATHSTFQPPRPPPPVRDY
GenBank ID Protein 7328925
UniProtKB/Swiss-Prot ID Q9P2U7
UniProtKB/Swiss-Prot Entry Name VGLU1_HUMAN
PDB IDs Not Available
GenBank Gene ID AB032436
GeneCard ID SLC17A7
GenAtlas ID SLC17A7
HGNC ID HGNC:16704
References
General References Not Available