| Identification |
|---|
| HMDB Protein ID
| CDBP02380 |
| Secondary Accession Numbers
| Not Available |
| Name
| Vesicular glutamate transporter 3 |
| Description
| Not Available |
| Synonyms
|
- Solute carrier family 17 member 8
- VGluT3
|
| Gene Name
| SLC17A8 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
|
| GO Classification
|
| Biological Process |
| sodium ion transport |
| neurotransmitter transport |
| transmembrane transport |
| sensory perception of sound |
| ion transport |
| Cellular Component |
| cell junction |
| neuron projection |
| integral to membrane |
| synaptic vesicle membrane |
| Molecular Function |
| symporter activity |
| L-glutamate transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Membrane
- Multi-pass membrane protein (Potential)
- secretory vesicle
- Cell junction
- synapse
- synaptosome
- synaptic vesicle membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Synaptic vesicle cycle | Not Available |  | | Retrograde endocannabinoid signaling | Not Available |  | | Glutamatergic synapse | Not Available |  | | Nicotine addiction | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q23.1 |
| SNPs
| SLC17A8 |
| Gene Sequence
|
>1770 bp
ATGCCTTTTAAAGCATTTGATACCTTCAAAGAAAAAATTCTGAAACCTGGGAAGGAAGGA
GTGAAGAACGCCGTGGGAGATTCTTTGGGAATTTTACAAAGAAAAATCGATGGGACAACT
GAGGAAGAAGATAACATTGAGCTGAATGAAGAAGGAAGGCCGGTGCAGACGTCCAGGCCA
AGCCCCCCACTCTGCGACTGCCACTGCTGCGGCCTCCCCAAGCGTTACATCATTGCTATC
ATGAGTGGGCTGGGATTCTGCATTTCCTTTGGGATCCGGTGCAATCTTGGAGTTGCCATT
GTGGAAATGGTCAACAATAGCACCGTATATGTTGATGGAAAACCGGAAATTCAGACAGCA
CAGTTTAACTGGGATCCAGAAACAGTGGGCCTTATCCATGGATCTTTTTTCTGGGGCTAT
ATTATGACACAAATTCCAGGTGGTTTCATTTCAAACAAGTTTGCTGCTAACAGGGTCTTT
GGAGCTGCCATCTTCTTAACATCGACTCTGAACATGTTTATTCCCTCTGCAGCCAGAGTG
CATTACGGATGCGTCATGTGTGTCAGAATTCTGCAAGGTTTAGTGGAGGGTGTGACCTAC
CCAGCCTGCCATGGGATGTGGAGTAAGTGGGCACCACCTTTGGAGAGAAGCCGACTGGCC
ACAACCTCTTTTTGTGGTTCCTATGCAGGGGCAGTGGTTGCCATGCCCCTGGCTGGGGTG
TTGGTGCAGTACATTGGATGGTCCTCTGTCTTTTATATTTATGGCATGTTTGGGATTATT
TGGTACATGTTTTGGCTGTTGCAGGCCTATGAGTGCCCAGCAGCTCATCCAACAATATCC
AATGAGGAGAAGACCTATATAGAGACAAGCATAGGAGAGGGGGCCAACGTGGTTAGTCTA
AGTAAATTTAGTACCCCATGGAAAAGATTTTTCACATCTTTGCCGGTTTACGCAATCATT
GTGGCAAATTTTTGCAGAAGCTGGACCTTTTATTTGCTCCTCATAAGTCAGCCTGCTTAT
TTTGAAGAGGTCTTTGGATTTGCAATAAGTAAGGTGGGTCTCTTGTCAGCAGTCCCACAC
ATGGTTATGACAATCGTTGTACCTATTGGAGGACAATTGGCTGATTATTTAAGAAGCAGA
CAAATTTTAACCACAACTGCTGTCAGAAAAATCATGAACTGTGGAGGTTTTGGCATGGAG
GCAACCTTACTCCTGGTGGTTGGCTTTTCGCATACCAAAGGGGTGGCTATCTCCTTTCTG
GTACTTGCTGTAGGATTTAGTGGCTTCGCTATTTCAGGTTTTAATGTCAACCACCTGGAC
ATTGCCCCACGCTATGCCAGCATTCTCATGGGGATCTCAAACGGAGTGGGAACCCTCTCT
GGAATGGTCTGTCCCCTCATTGTCGGTGCAATGACCAGGCACAAGACCCGTGAAGAATGG
CAGAATGTGTTCCTCATAGCTGCCCTGGTGCATTACAGTGGTGTGATCTTCTATGGGGTC
TTTGCTTCTGGGGAGAAACAGGAGTGGGCTGACCCAGAGAATCTCTCTGAGGAGAAATGT
GGAATCATTGACCAGGACGAATTAGCTGAGGAGATAGAACTCAACCATGAGAGTTTTGCG
AGTCCCAAAAAGAAGATGTCTTATGGAGCCACCTCCCAGAATTGTGAAGTCCAGAAGAAG
GAATGGAAAGGACAGAGAGGAGCGACCCTTGATGAGGAAGAGCTGACATCCTACCAGAAT
GAAGAGAGAAACTTCTCAACTATATCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 589 |
| Molecular Weight
| 59076.69 |
| Theoretical pI
| 5.94 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Vesicular glutamate transporter 3
MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRP
SPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTA
QFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARV
HYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGV
LVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSL
SKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPH
MVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFL
VLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEW
QNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEIELNHESFA
SPKKKMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS
|
| External Links |
|---|
| GenBank ID Protein
| 21213895 |
| UniProtKB/Swiss-Prot ID
| Q8NDX2 |
| UniProtKB/Swiss-Prot Entry Name
| VGLU3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ459241 |
| GeneCard ID
| SLC17A8 |
| GenAtlas ID
| SLC17A8 |
| HGNC ID
| HGNC:20151 |
| References |
|---|
| General References
| Not Available |