Cannabis Compound Database: Showing Protein Thymidine kinase 2, mitochondrial (CDBP02371)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP02371

Secondary Accession Numbers

Not Available

Name

Thymidine kinase 2, mitochondrial

Description

Not Available

Synonyms

Mt-TK

Gene Name

TK2

Protein Type

Enzyme

Biological Properties

General Function

Involved in ATP binding

Specific Function

Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.

GO Classification

Biological Process
deoxyribonucleotide metabolic process
mitochondrial DNA replication
pyrimidine nucleoside salvage
pyrimidine nucleobase metabolic process
Cellular Component
mitochondrial matrix
mitochondrial inner membrane
Function
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
phosphotransferase activity, alcohol group as acceptor
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
Molecular Function
thymidine kinase activity
phosphotransferase activity, alcohol group as acceptor
ATP binding
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
Drug metabolism - other enzymes	Not Available

Gene Properties

Chromosome Location

Locus

16q22-q23.1

SNPs

TK2

Gene Sequence

>798 bp
ATGCTGCTGTGGCCGCTGCGGGGCTGGGCCGCCCGGGCGCTGCGCTGCTTTGGGCCGGGA
AGTCGCGGGAGCCCGGCCTCAGGCCCCGGGCCGCGGAGGGTGCAGCGCCGGGCCTGGCCT
CCCGATAAAGAACAGGAAAAAGAGAAAAAATCAGTGATCTGTGTCGAGGGCAATATTGCA
AGTGGGAAGACGACATGCCTGGAATTCTTCTCCAACGCGACAGACGTCGAGGTGTTAACG
GAGCCTGTGTCCAAGTGGAGAAATGTCCGTGGCCACAATCCTCTGGGCCTGATGTACCAC
GATGCCTCTCGCTGGGGTCTTACGCTACAGACTTATGTGCAGCTCACCATGCTGGACAGG
CATACTCGTCCTCAGGTGTCATCTGTACGGTTGATGGAGAGGTCGATTCACAGCGCAAGA
TACATTTTTGTAGAAAACCTGTATAGAAGTGGGAAGATGCCAGAAGTGGACTATGTAGTT
CTGTCGGAATGGTTTGACTGGATCTTGAGGAACATGGACGTGTCTGTTGATTTGATAGTT
TACCTTCGGACCAATCCTGAGACTTGTTACCAGAGGTTAAAGAAGAGATGCAGGGAAGAG
GAGAAGGTCATTCCGCTGGAATACCTGGAAGCAATTCACCATCTCCATGAGGAGTGGCTC
ATCAAAGGCAGCCTTTTCCCCATGGCAGCCCCTGTTCTGGTGATTGAGGCTGACCACCAC
ATGGAGAGGATGTTAGAACTCTTTGAACAAAATCGGGATCGAATATTAACTCCAGAGAAT
CGGAAGCATTGCCCATAG

Protein Properties

Number of Residues

265

Molecular Weight

27561.495

Theoretical pI

6.849

Pfam Domain Function

dNK (PF01712 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Thymidine kinase 2, mitochondrial
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP

External Links

GenBank ID Protein

290656936

UniProtKB/Swiss-Prot ID

O00142

UniProtKB/Swiss-Prot Entry Name

KITM_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_004614.4

GeneCard ID