| Identification |
|---|
| HMDB Protein ID
| CDBP02371 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thymidine kinase 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Mt-TK
|
| Gene Name
| TK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.
|
| GO Classification
|
| Biological Process |
| deoxyribonucleotide metabolic process |
| mitochondrial DNA replication |
| pyrimidine nucleoside salvage |
| pyrimidine nucleobase metabolic process |
| Cellular Component |
| mitochondrial matrix |
| mitochondrial inner membrane |
| Function |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| phosphotransferase activity, alcohol group as acceptor |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleoside binding |
| Molecular Function |
| thymidine kinase activity |
| phosphotransferase activity, alcohol group as acceptor |
| ATP binding |
| Process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Drug metabolism - other enzymes | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16q22-q23.1 |
| SNPs
| TK2 |
| Gene Sequence
|
>798 bp
ATGCTGCTGTGGCCGCTGCGGGGCTGGGCCGCCCGGGCGCTGCGCTGCTTTGGGCCGGGA
AGTCGCGGGAGCCCGGCCTCAGGCCCCGGGCCGCGGAGGGTGCAGCGCCGGGCCTGGCCT
CCCGATAAAGAACAGGAAAAAGAGAAAAAATCAGTGATCTGTGTCGAGGGCAATATTGCA
AGTGGGAAGACGACATGCCTGGAATTCTTCTCCAACGCGACAGACGTCGAGGTGTTAACG
GAGCCTGTGTCCAAGTGGAGAAATGTCCGTGGCCACAATCCTCTGGGCCTGATGTACCAC
GATGCCTCTCGCTGGGGTCTTACGCTACAGACTTATGTGCAGCTCACCATGCTGGACAGG
CATACTCGTCCTCAGGTGTCATCTGTACGGTTGATGGAGAGGTCGATTCACAGCGCAAGA
TACATTTTTGTAGAAAACCTGTATAGAAGTGGGAAGATGCCAGAAGTGGACTATGTAGTT
CTGTCGGAATGGTTTGACTGGATCTTGAGGAACATGGACGTGTCTGTTGATTTGATAGTT
TACCTTCGGACCAATCCTGAGACTTGTTACCAGAGGTTAAAGAAGAGATGCAGGGAAGAG
GAGAAGGTCATTCCGCTGGAATACCTGGAAGCAATTCACCATCTCCATGAGGAGTGGCTC
ATCAAAGGCAGCCTTTTCCCCATGGCAGCCCCTGTTCTGGTGATTGAGGCTGACCACCAC
ATGGAGAGGATGTTAGAACTCTTTGAACAAAATCGGGATCGAATATTAACTCCAGAGAAT
CGGAAGCATTGCCCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 265 |
| Molecular Weight
| 27561.495 |
| Theoretical pI
| 6.849 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thymidine kinase 2, mitochondrial
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP
|
| External Links |
|---|
| GenBank ID Protein
| 290656936 |
| UniProtKB/Swiss-Prot ID
| O00142 |
| UniProtKB/Swiss-Prot Entry Name
| KITM_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004614.4 |
| GeneCard ID
| TK2 |
| GenAtlas ID
| TK2 |
| HGNC ID
| HGNC:11831 |
| References |
|---|
| General References
| Not Available |