| Identification |
|---|
| HMDB Protein ID
| CDBP02370 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thymidine kinase, cytosolic |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| TK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| pyrimidine nucleoside salvage |
| pyrimidine nucleobase metabolic process |
| DNA replication |
| protein homotetramerization |
| Cellular Component |
| cytosol |
| Function |
| nucleobase, nucleoside, nucleotide kinase activity |
| adenyl nucleotide binding |
| atp binding |
| nucleoside kinase activity |
| deoxynucleoside kinase activity |
| thymidine kinase activity |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| Molecular Function |
| thymidine kinase activity |
| metal ion binding |
| ATP binding |
| zinc ion binding |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Drug metabolism - other enzymes | Not Available |  | | Pyrimidine Metabolism |    |  | | Beta Ureidopropionase Deficiency |    | Not Available | | UMP Synthase Deficiency (Orotic Aciduria) |    | Not Available | | Dihydropyrimidinase Deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q23.2-q25.3 |
| SNPs
| TK1 |
| Gene Sequence
|
>705 bp
ATGAGCTGCATTAACCTGCCCACTGTGCTGCCCGGCTCCCCCAGCAAGACCCGGGGGCAG
ATCCAGGTGATTCTCGGGCCGATGTTCTCAGGAAAAAGCACAGAGTTGATGAGACGCGTC
CGTCGCTTCCAGATTGCTCAGTACAAGTGCCTGGTGATCAAGTATGCCAAAGACACTCGC
TACAGCAGCAGCTTCTGCACACATGACCGGAACACCATGGAGGCGCTGCCCGCCTGCCTG
CTCCGAGACGTGGCCCAGGAGGCCCTGGGCGTGGCTGTCATAGGCATCGACGAGGGGCAG
TTTTTCCCTGACATCATGGAGTTCTGCGAGGCCATGGCCAACGCCGGGAAGACCGTAATT
GTGGCTGCACTGGATGGGACCTTCCAGAGGAAGCCATTTGGGGCCATCCTGAACCTGGTG
CCGCTGGCCGAGAGCGTGGTGAAGCTGACGGCGGTGTGCATGGAGTGCTTCCGGGAAGCC
GCCTATACCAAGAGGCTCGGCACAGAGAAGGAGGTCGAGGTGATTGGGGGAGCAGACAAG
TACCACTCCGTGTGTCGGCTCTGCTACTTCAAGAAGGCCTCAGGCCAGCCTGCCGGGCCG
GACAACAAAGAGAACTGCCCAGTGCCAGGAAAGCCAGGGGAAGCCGTGGCTGCCAGGAAG
CTCTTTGCCCCACAGCAGATTCTGCAATGCAGCCCTGCCAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 234 |
| Molecular Weight
| 25468.455 |
| Theoretical pI
| 8.51 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thymidine kinase, cytosolic
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
|
| External Links |
|---|
| GenBank ID Protein
| 339709 |
| UniProtKB/Swiss-Prot ID
| P04183 |
| UniProtKB/Swiss-Prot Entry Name
| KITH_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| K02581 |
| GeneCard ID
| TK1 |
| GenAtlas ID
| TK1 |
| HGNC ID
| HGNC:11830 |
| References |
|---|
| General References
| Not Available |