Cannabis Compound Database: Showing Protein Putative N-acetylglucosamine-6-phosphate deacetylase (CDBP02361)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02361

Secondary Accession Numbers

Not Available

Name

Putative N-acetylglucosamine-6-phosphate deacetylase

Description

Not Available

Synonyms

Amidohydrolase domain-containing protein 2
GlcNAc 6-P deacetylase

Gene Name

AMDHD2

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity

Specific Function

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

GO Classification

Biological Process
N-acetylneuraminate catabolic process
N-acetylglucosamine metabolic process
carbohydrate metabolic process
Function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
n-acetylglucosamine-6-phosphate deacetylase activity
catalytic activity
hydrolase activity
Molecular Function
metal ion binding
N-acetylglucosamine-6-phosphate deacetylase activity
Process
metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
amino sugar metabolic process
glucosamine metabolic process
n-acetylglucosamine metabolic process

Cellular Location

Cytoplasmic

Pathways

Name	SMPDB/Pathwhiz	KEGG
Amino Sugar Metabolism
N-acetylneuraminate degradation	Not Available	Not Available
Amino sugar and nucleotide sugar metabolism	Not Available
Sialuria or French Type Sialuria		Not Available
Salla Disease/Infantile Sialic Acid Storage Disease		Not Available

Gene Properties

Chromosome Location

Locus

16p13.3

SNPs

AMDHD2

Gene Sequence

>1320 bp
ATGCGCGGCGAGCAGGGCGCGGCGGGGGCCCGCGTGCTCCAGTTCACTAACTGCCGGATC
CTGCGCGGAGGGAAACTGCTCAGGGAGGATCTGTGGGTGCGCGGAGGCCGCATCTTGGAC
CCAGAGAAGCTGTTCTTTGAGGAGCGGCGCGTGGCCGACGAGCGGCGGGACTGCGGGGGC
CGCATCTTGGCTCCCGGATTCATCGACGTGCAGATCAACGGTGGATTTGGTGTTGACTTC
TCTCAAGCCACGGAGGACGTGGGTTCGGGGGTTGCCCTCGTGGCCCGGAGGATCCTGTCG
CACGGCGTCACCTCCTTCTGCCCCACCCTGGTCACTTCCCCACCGGAGGTTTATCACAAG
GTTGTTCCTCAGATCCCTGTGAAGAGTGGTGGTCCCCATGGGGCAGGGGTCCTCGGGCTG
CACCTGGAGGGCCCCTTCATCAGCCGGGAGAAGCGGGGCGCGCACCCCGAGGCCCACCTC
CGCTCCTTCGAGGCCGATGCCTTCCAGGACTTGCTGGCCACCTACGGGCCCCTGGACAAT
GTCCGCATCGTGACGCTGGCCCCAGAGTTGGGCCGTAGCCACGAAGTGATCCGGGCGCTG
ACGGCCCGTGGCATCTGCGTGTCCCTAGGGCACTCAGTGGCTGACCTGCGGGCGGCAGAG
GATGCTGTGTGGAGCGGAGCCACCTTCATCACCCACCTCTTCAACGCCATGCTGCCTTTC
CACCACCGCGACCCAGGCATCGTGGGGCTCCTGACCAGCGACCGGCTGCCCGCAGGCCGC
TGCATCTTCTATGGGATGATTGCAGATGGCACGCACACCAACCCCGCCGCCCTGCGGATC
GCCCACCGTGCCCATCCCCAGGGGCTGGTGCTGGTCACCGATGCCATCCCTGCCTTGGGC
CTGGGCAACGGCCGGCACACGCTGGGACAGCAGGAAGTGGAAGTGGACGGTCTGACGGCC
TACGTGGCAGGTGAGCGCCCTGACCCACTGGGTCCCAGGTCCCAGCCCGCATGCCAGGTG
GCCCACGACCCCCCCAGAGCCTGCCCTCTCTGCTCTCAAGGCACCAAGACGCTGAGTGGC
AGCATAGCCCCAATGGACGTCTGTGTCCGGCACTTCCTGCAGGCCACAGGCTGCAGCATG
GAGTCGGCCCTGGAGGCTGCATCCCTGCACCCCGCCCAGTTGCTGGGGCTGGAGAAGAGT
AAGGGGACCCTGGACTTTGGTGCTGACGCAGACTTCGTGGTGCTCGACGACTCCCTTCAC
GTCCAGGCCACCTACATCTCGGGTGAGCTGGTGTGGCAGGCGGACGCAGCTAGGCAGTGA

Protein Properties

Number of Residues

409

Molecular Weight

63594.415

Theoretical pI

7.526

Pfam Domain Function

Amidohydro_1 (PF01979 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Putative N-acetylglucosamine-6-phosphate deacetylase
MRGEQGAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGG
RILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHK
VVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDN
VRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPF
HHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALG
LGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLH
PAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADAARQ

External Links

GenBank ID Protein

21361513

UniProtKB/Swiss-Prot ID

Q9Y303

UniProtKB/Swiss-Prot Entry Name

NAGA_HUMAN

PDB IDs

Not Available

GenBank Gene ID

Not Available

GeneCard ID