| Identification |
|---|
| HMDB Protein ID
| CDBP02348 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cardiolipin synthase |
| Description
| Not Available |
| Synonyms
|
- CLS
- Protein GCD10 homolog
|
| Gene Name
| CRLS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphotransferase activity, for other substituted phosphate groups |
| Specific Function
| Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| cardiolipin biosynthetic process |
| phosphatidylglycerol acyl-chain remodeling |
| Cellular Component |
| integral to membrane |
| mitochondrial inner membrane |
| Component |
| membrane |
| cell part |
| Function |
| phosphotransferase activity, for other substituted phosphate groups |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| Molecular Function |
| phosphotransferase activity, for other substituted phosphate groups |
| Process |
| metabolic process |
| phospholipid biosynthetic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Phospholipid Biosynthesis |    |  | | Glycerophospholipid metabolism | Not Available | | | Cardiolipin Biosynthesis CL(i-13:0/i-16:0/i-13:0/i-17:0) |    | Not Available | | Cardiolipin Biosynthesis CL(i-14:0/i-15:0/i-20:0/i-18:0) |    | Not Available | | Cardiolipin Biosynthesis CL(a-13:0/i-12:0/a-15:0/i-12:0) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20p13-p12.3 |
| SNPs
| CRLS1 |
| Gene Sequence
|
>906 bp
ATGCTAGCCTTGCGCGTGGCGCGCGGCTCGTGGGGGGCCCTGCGCGGCGCCGCTTGGGCT
CCGGGAACGCGGCCGAGTAAGCGACGCGCCTGCTGGGCCCTGCTGCCGCCCGTGCCCTGC
TGCTTGGGCTGCCTGGCCGAACGCTGGAGGCTGCGTCCGGCCGCTCTTGGCTTGCGGCTG
CCCGGGATCGGCCAGCGGAACCACTGTTCGGGCGCGGGGAAGGCGGCTCCCAGGCCAGCG
GCCGGAGCGGGCGCCGCTGCCGAAGCCCCGGGCGGCCAGTGGGGCCCGGCGAGCACCCCC
AGCCTGTATGAAAACCCATGGACAATCCCGAATATGTTGTCAATGACGAGAATTGGCTTG
GCCCCAGTTCTGGGCTATTTGATTATTGAAGAAGATTTTAATATTGCACTAGGAGTTTTT
GCTTTAGCTGGACTAACAGATTTGTTGGATGGATTTATTGCTCGAAACTGGGCCAATCAA
AGATCAGCTTTGGGAAGTGCTCTTGATCCACTTGCTGATAAAATACTTATCAGTATCTTA
TATGTTAGCTTGACCTATGCAGATCTTATTCCAGTTCCACTTACTTACATGATCATTTCG
AGAGATGTAATGTTGATTGCTGCTGTTTTTTATGTCAGATACCGAACTCTTCCAACACCA
CGAACACTTGCCAAGTATTTCAATCCTTGCTATGCCACTGCTAGGTTAAAACCAACATTC
ATCAGCAAGGTGAATACAGCAGTCCAGTTAATCTTGGTGGCAGCTTCTTTGGCAGCTCCA
GTTTTCAACTATGCTGACAGCATTTATCTTCAGATACTATGGTGTTTTACAGCTTTCACC
ACAGCTGCATCAGCTTATAGTTACTATCATTATGGCCGGAAGACTGTTCAGGTGATAAAA
GACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 301 |
| Molecular Weight
| 22583.205 |
| Theoretical pI
| 8.683 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cardiolipin synthase
MLALRVARGSWGALRGAAWAPGTRPSKRRACWALLPPVPCCLGCLAERWRLRPAALGLRL
PGIGQRNHCSGAGKAAPRPAAGAGAAAEAPGGQWGPASTPSLYENPWTIPNMLSMTRIGL
APVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNWANQRSALGSALDPLADKILISIL
YVSLTYADLIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPRTLAKYFNPCYATARLKPTF
ISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCFTAFTTAASAYSYYHYGRKTVQVIK
D
|
| External Links |
|---|
| GenBank ID Protein
| 12005485 |
| UniProtKB/Swiss-Prot ID
| Q9UJA2 |
| UniProtKB/Swiss-Prot Entry Name
| CRLS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF241784 |
| GeneCard ID
| CRLS1 |
| GenAtlas ID
| CRLS1 |
| HGNC ID
| HGNC:16148 |
| References |
|---|
| General References
| Not Available |