| Identification |
|---|
| HMDB Protein ID
| CDBP02347 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 |
| Description
| Not Available |
| Synonyms
|
- GalNAc alpha-2,6-sialyltransferase VI
- SIAT7-F
- ST6GalNAc VI
- ST6GalNAcVI
- Sialyltransferase 7F
- hST6GalNAc VI
|
| Gene Name
| ST6GALNAC6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sialyltransferase activity |
| Specific Function
| Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)), a representative tumor-associated antigen in cancers of the pancreas and colon, in colon tissues |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| intrinsic to organelle membrane |
| intrinsic to golgi membrane |
| integral to golgi membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring glycosyl groups |
| sialyltransferase activity |
| Process |
| protein modification process |
| protein amino acid glycosylation |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q34.11 |
| SNPs
| ST6GALNAC6 |
| Gene Sequence
|
>1002 bp
ATGGCTTGCTCGAGGCCCCCCAGCCAGTGTGAACCCACATCCCTGCCCCCAGGGCCACCT
GCAGGACGCCGACACCTACCCCTCAGCAGACGCCGGAGAGAAATGAGTAGCAACAAAGAG
CAGCGGTCAGCAGTGTTCGTGATCCTCTTTGCCCTCATCACCATCCTCATCCTCTACAGC
TCCAACAGTGCCAATGAGGTCTTCCATTACGGCTCCCTGCGGGGCCGTAGCCGCCGACCT
GTCAACCTCAAGAAGTGGAGCATCACTGACGGCTATGTCCCCATTCTCGGCAACAAGACA
CTGCCCTCTCGGTGCCACCAGTGTGTGATTGTCAGCAGCTCCAGCCACCTGCTGGGCACC
AAGCTGGGCCCTGAGATCGAGCGGGCTGAGTGTACAATCCGCATGAATGATGCACCCACC
ACTGGCTACTCAGCTGATGTGGGCAACAAGACCACCTACCGCGTCGTGGCCCATTCCAGT
GTGTTCCGCGTGCTGAGGAGGCCCCAGGAGTTTGTCAACCGGACCCCTGAAACCGTGTTC
ATCTTCTGGGGGCCCCCGAGCAAGATGCAGAAGCCCCAGGGCAGCCTCGTGCGTGTGATC
CAGCGAGCGGGCCTGGTGTTCCCCAACATGGAAGCATATGCCGTCTCTCCCGGCCGCATG
CGGCAATTTGACGACCTCTTCCGGGGTGAGACGGGCAAGGACAGGGAGAAGTCTCATTCG
TGGTTGAGCACAGGCTGGTTTACCATGGTGATCGCGGTGGAGTTGTGTGACCACGTGCAT
GTCTATGGCATGGTCCCCCCCAACTACTGCAGCCAGCGGCCCCGCCTCCAGCGCATGCCC
TACCACTACTACGAGCCCAAGGGGCCGGACGAATGTGTCACCTACATCCAGAATGAGCAC
AGTCGCAAGGGCAACCACCACCGCTTCATCACCGAGAAAAGGGTCTTCTCATCGTGGGCC
CAGCTGTATGGCATCACCTTCTCCCACCCCTCCTGGACCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 333 |
| Molecular Weight
| 38067.3 |
| Theoretical pI
| 10.29 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
MACSRPPSQCEPTSLPPGPPAGRRHLPLSRRRREMSSNKEQRSAVFVILFALITILILYS
SNSANEVFHYGSLRGRSRRPVNLKKWSITDGYVPILGNKTLPSRCHQCVIVSSSSHLLGT
KLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVF
IFWGPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHS
WLSTGWFTMVIAVELCDHVHVYGMVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEH
SRKGNHHRFITEKRVFSSWAQLYGITFSHPSWT
|
| External Links |
|---|
| GenBank ID Protein
| 21361444 |
| UniProtKB/Swiss-Prot ID
| Q969X2 |
| UniProtKB/Swiss-Prot Entry Name
| SIA7F_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_013443.3 |
| GeneCard ID
| ST6GALNAC6 |
| GenAtlas ID
| ST6GALNAC6 |
| HGNC ID
| HGNC:23364 |
| References |
|---|
| General References
| Not Available |