Cannabis Compound Database: Showing Protein Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (CDBP02323)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02323

Secondary Accession Numbers

Not Available

Name

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Description

Not Available

Synonyms

DAD-1
Defender against cell death 1
Oligosaccharyl transferase subunit DAD1

Gene Name

DAD1

Protein Type

Enzyme

Biological Properties

General Function

Involved in dolichyl-diphosphooligosaccharide-protein g

Specific Function

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity).

GO Classification

Biological Process
apoptotic process
negative regulation of apoptotic process
response to drug
post-translational protein modification
protein N-linked glycosylation via asparagine
response to nutrient
blastocyst development
Cellular Component
oligosaccharyltransferase complex
integral to membrane
Molecular Function
transferase activity, transferring glycosyl groups

Cellular Location

Membrane
Multi-pass membrane protein (Potential)

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein glycosylation	Not Available	Not Available
N-Glycan biosynthesis	Not Available
Protein processing in endoplasmic reticulum	Not Available

Gene Properties

Chromosome Location

Locus

14q11.2

SNPs

DAD1

Gene Sequence

>342 bp
ATGTCGGCGTCGGTAGTGTCTGTCATTTCGCGGTTCTTAGAAGAGTACTTGAGCTCCACT
CCGCAGCGTCTGAAGTTGCTGGACGCGTACCTGCTGTATATACTGCTGACCGGGGCGCTG
CAGTTCGGTTACTGTCTCCTCGTGGGGACCTTCCCCTTCAACTCTTTTCTCTCGGGCTTC
ATCTCTTGTGTGGGGAGTTTCATCCTAGCGGTTTGCCTGAGAATACAGATCAACCCACAG
AACAAAGCGGATTTCCAAGGCATCTCCCCAGAGCGAGCCTTTGCTGATTTTCTCTTTGCC
AGCACCATCCTGCACCTTGTTGTCATGAACTTTGTTGGCTGA

Protein Properties

Number of Residues

113

Molecular Weight

12496.55

Theoretical pI

7.076

Pfam Domain Function

DAD (PF02109 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGF
ISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG

External Links

GenBank ID Protein

29501770

UniProtKB/Swiss-Prot ID

P61803

UniProtKB/Swiss-Prot Entry Name

DAD1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AY259117

GeneCard ID