| Identification |
|---|
| HMDB Protein ID
| CDBP02310 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carbohydrate sulfotransferase 5 |
| Description
| Not Available |
| Synonyms
|
- GST4-alpha
- Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha
- GlcNAc6ST-3
- Gn6st-3
- I-GlcNAc6ST
- Intestinal GlcNAc-6-sulfotransferase
- Intestinal N-acetylglucosamine-6-O-sulfotransferase
- N-acetylglucosamine 6-O-sulfotransferase 3
- hIGn6ST
|
| Gene Name
| CHST5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| Catalyzes the transfer of sulfate to position 6 of non- reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N- acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for L-selectin. Its substrate specificity may be influenced by its subcellular location |
| GO Classification
|
| Component |
| golgi membrane |
| membrane |
| cell part |
| organelle membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| Process |
| carbohydrate metabolic process |
| metabolic process |
| primary metabolic process |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q22.3 |
| SNPs
| CHST5 |
| Gene Sequence
|
>1236 bp
ATGGGCATGAGGGCCCGGGTCCCTAAAGTTGCCCACTCCACCCGAAGGCCCCCAGCCGCC
CGCATGTGGCTGCCACGGTTCTCCAGCAAGACAGTGACAGTGCTCCTCCTGGCACAGACC
ACCTGCCTCCTGCTCTTCATCATCTCCCGGCCAGGGCCCTCATCCCCAGCCGGCGGCGAG
GATCGTGTGCACGTGCTGGTGCTGTCCTCGTGGCGCTCGGGCTCATCCTTCTTGGGCCAG
CTCTTCAGCCAGCACCCCGACGTCTTCTACCTGATGGAGCCCGCGTGGCATGTGTGGACC
ACCCTGTCGCAGGGCAGCGCGGCAACGCTGCACATGGCCGTGCGCGACCTGATGCGCTCT
ATCTTTTTGTGCGACATGGACGTGTTTGATGCCTACATGCCACAGAGCCGAAACCTGTCC
GCCTTTTTCAACTGGGCAACGAGCCGCGCGCTGTGCTCGCCGCCCGCCTGCAGCGCCTTT
CCCCGAGGCACCATCAGCAAGCAGGACGTATGCAAGACACTGTGCACGCGGCAGCCATTC
AGCCTGGCCCGGGAGGCCTGCCGCTCCTACAGCCACGTGGTGCTCAAGGAGGTGCGCTTC
TTCAACCTGCAGGTGCTCTACCCGCTGCTCAGCGACCCCGCGCTCAACCTGCGCATCGTG
CACCTGGTGCGCGACCCGCGGGCCGTGCTGCGCTCCCGGGAGGCGGCGGGCCCGATACTG
GCACGCGACAACGGCATCGTGCTGGGCACCAACGGCAAGTGGGTGGAGGCCGACCCTCAC
CTGCGCCTGATTCGCGAGGTGTGCCGCAGCCACGTGCGCATCGCCGAGGCCGCCACACTC
AAGCCGCCACCCTTCCTGCGCGGCCGCTACCGCCTGGTGCGCTTCGAGGACCTGGCGCGG
GAGCCGCTGGCAGAGATCCGCGCACTCTACGCCTTCACCGGCCTGACCCTCACGCCACAG
CTCGAGGCCTGGATCCACAACATCACCCACGGGTCGGGGATCGGCAAGCCAATCGAGGCC
TTCCATACTTCGTCTAGGAATGCGCGCAACGTCTCCCAGGCCTGGCGCCACGCGTTGCCC
TTCACTAAGATCCTGCGCGTGCAGGAGGTGTGCGCCGGCGCGCTGCAGCTGCTGGGCTAC
CGGCCTGTGTACTCTGCGGACCAGCAGCGTGACCTCACCCTGGATCTGGTGCTGCCACGA
GGCCCAGACCACTTCAGCTGGGCATCGCCTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 411 |
| Molecular Weight
| 46160.0 |
| Theoretical pI
| 10.5 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Carbohydrate sulfotransferase 5
MGMRARVPKVAHSTRRPPAARMWLPRFSSKTVTVLLLAQTTCLLLFIISRPGPSSPAGGE
DRVHVLVLSSWRSGSSFLGQLFSQHPDVFYLMEPAWHVWTTLSQGSAATLHMAVRDLMRS
IFLCDMDVFDAYMPQSRNLSAFFNWATSRALCSPPACSAFPRGTISKQDVCKTLCTRQPF
SLAREACRSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREAAGPIL
ARDNGIVLGTNGKWVEADPHLRLIREVCRSHVRIAEAATLKPPPFLRGRYRLVRFEDLAR
EPLAEIRALYAFTGLTLTPQLEAWIHNITHGSGIGKPIEAFHTSSRNARNVSQAWRHALP
FTKILRVQEVCAGALQLLGYRPVYSADQQRDLTLDLVLPRGPDHFSWASPD
|
| External Links |
|---|
| GenBank ID Protein
| 21362052 |
| UniProtKB/Swiss-Prot ID
| Q9GZS9 |
| UniProtKB/Swiss-Prot Entry Name
| CHST5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_024533.3 |
| GeneCard ID
| CHST5 |
| GenAtlas ID
| CHST5 |
| HGNC ID
| HGNC:1973 |
| References |
|---|
| General References
| Not Available |