Identification |
HMDB Protein ID
| CDBP02309 |
Secondary Accession Numbers
| Not Available |
Name
| Gamma-glutamyl hydrolase |
Description
| Not Available |
Synonyms
|
- Conjugase
- GH
- Gamma-Glu-X carboxypeptidase
|
Gene Name
| GGH |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
|
GO Classification
|
Biological Process |
response to zinc ion |
glutamine metabolic process |
response to insulin stimulus |
response to drug |
response to ethanol |
Cellular Component |
cytosol |
melanosome |
lysosome |
extracellular space |
Function |
hydrolase activity |
omega peptidase activity |
peptidase activity |
peptidase activity, acting on l-amino acid peptides |
exopeptidase activity |
catalytic activity |
Molecular Function |
gamma-glutamyl-peptidase activity |
Process |
metabolic process |
cellular metabolic process |
glutamine metabolic process |
glutamine family amino acid metabolic process |
cellular amino acid and derivative metabolic process |
cellular amino acid metabolic process |
|
Cellular Location
|
- Melanosome
- Lysosome
- Secreted
- extracellular space
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Folate biosynthesis | Not Available | ![Map00790](https://www.genome.jp/kegg/misc/thumbnail/map00790.gif) | Folate Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000024/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000024/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000024/thumb?image_type=simple) | ![Map00670](https://www.genome.jp/kegg/misc/thumbnail/map00670.gif) | Methotrexate Action Pathway | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000268/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000268/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000268/thumb?image_type=simple) | Not Available | Folate malabsorption, hereditary | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000701/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000701/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000701/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| 8 |
Locus
| 8q12.3 |
SNPs
| GGH |
Gene Sequence
|
>957 bp
ATGGCCAGTCCGGGCTGCCTGCTGTGCGTGCTGGGCCTGCTACTCTGCGGGGCGGCGAGC
CTCGAGCTGTCTAGACCCCACGGCGACACCGCCAAGAAGCCCATCATCGGAATATTAATG
CAAAAATGCCGTAATAAAGTCATGAAAAACTATGGAAGATACTATATTGCTGCGTCCTAT
GTAAAGTACTTGGAGTCTGCAGGTGCGAGAGTTGTACCAGTAAGGCTGGATCTTACAGAG
AAAGACTATGAAATACTTTTCAAATCTATTAATGGAATCCTTTTCCCTGGAGGAAGTGTT
GACCTCAGACGCTCAGATTATGCTAAAGTGGCCAAAATATTTTATAACTTGTCCATACAG
AGTTTTGATGATGGAGACTATTTTCCTGTGTGGGGCACATGCCTTGGATTTGAAGAGCTT
TCACTGCTGATTAGTGGAGAGTGCTTATTAACTGCCACAGATACTGTTGACGTGGCAATG
CCGCTGAACTTCACTGGAGGTCAATTGCACAGCAGAATGTTCCAGAATTTTCCTACTGAG
TTGTTGCTGTCATTAGCAGTAGAACCTCTGACTGCCAATTTCCATAAGTGGAGCCTCTCC
GTGAAGAATTTTACAATGAATGAAAAGTTAAAGAAGTTTTTCAATGTCTTAACTACAAAT
ACAGATGGCAAGATTGAGTTTATTTCAACAATGGAAGGATATAAGTATCCAGTATATGGT
GTCCAGTGGCATCCAGAGAAAGCACCTTATGAGTGGAAGAATTTGGATGGCATTTCCCAT
GCACCTAATGCTGTGAAAACCGCATTTTATTTAGCAGAGTTTTTTGTTAATGAAGCTCGG
AAAAACAACCATCATTTTAAATCTGAATCTGAAGAGGAGAAAGCATTGATTTATCAGTTC
AGTCCAATTTATACTGGAAATATTTCTTCATTTCAGCAATGTTACATATTTGATTGA
|
Protein Properties |
Number of Residues
| 318 |
Molecular Weight
| 35964.045 |
Theoretical pI
| 7.111 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Gamma-glutamyl hydrolase
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASY
VKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQ
SFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTE
LLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYG
VQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQF
SPIYTGNISSFQQCYIFD
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q92820 |
UniProtKB/Swiss-Prot Entry Name
| GGH_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| U55206 |
GeneCard ID
| GGH |
GenAtlas ID
| GGH |
HGNC ID
| HGNC:4248 |
References |
General References
| Not Available |