2308

CDBP02307

Fatty acid desaturase 2

O95864

FADS2_HUMAN

true false

Enzyme

Homo_sapiens

FADS2

444

52259.1

9.18

Involved in heme binding

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum

["None"]

["132-152", "158-178", "265-285", "306-326"]

AF126799

FADS2

Chromosome:1

11q12.2

FADS2

HGNC:3575

true

2020-06-12T23:07:03Z

2020-07-28T02:27:42Z