2307

CDBP02306

Sodium bicarbonate cotransporter 3

Q9Y6M7

S4A7_HUMAN

false true

Transporter

Homo_sapiens

SLC4A7

1214

127358.16

6.754

Involved in anion transport

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.

NM_003615.3

134288865

SLC4A7

3p22

SLC4A7

HGNC:11033

true

hsa:9497

NP_001245308.1:NM_001258379.1;NP_001245309.1:NM_001258380.1;NP_003606.3:NM_003615.4

Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.

Interacts with CFTR through SLC9A3R1/EBP50. Interacts with USH1C. Forms a complex with ATP6V1B1 and SLC9A3R1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2

2020-06-12T23:07:03Z

2020-07-28T02:27:42Z