| Identification |
|---|
| HMDB Protein ID
| CDBP02302 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aflatoxin B1 aldehyde reductase member 2 |
| Description
| Not Available |
| Synonyms
|
- AFB1 aldehyde reductase 1
- AFB1-AR 1
- Aldoketoreductase 7
- SSA reductase
- Succinic semialdehyde reductase
|
| Gene Name
| AKR7A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
|
| GO Classification
|
| Biological Process |
| doxorubicin metabolic process |
| carbohydrate metabolic process |
| cellular aldehyde metabolic process |
| daunorubicin metabolic process |
| Cellular Component |
| Golgi apparatus |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| electron carrier activity |
| alditol:NADP+ 1-oxidoreductase activity |
| phenanthrene-9,10-epoxide hydrolase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
- Golgi apparatus
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p36.13 |
| SNPs
| AKR7A2 |
| Gene Sequence
|
>1080 bp
ATGCTGAGTGCCGCGTCTCGCGTAGTCTCCCGCGCCGCCGTCCACTGCGCGCTTCGCTCT
CCGCCGCCCGAGGCCCGCGCGCTCGCCATGTCCCGGCCACCGCCACCGCGGGTCGCCTCG
GTGCTGGGCACCATGGAGATGGGGCGCCGCATGGACGCGCCCGCCAGCGCCGCGGCCGTG
CGCGCCTTTCTGGAGCGCGGCCACACCGAACTGGACACGGCCTTCATGTACAGCGACGGC
CAGTCCGAGACCATCCTGGGCGGCCTGGGGCTCGGGCTGGGCGGTGGCGACTGCAGAGTG
AAAATTGCCACCAAGGCCAACCCTTGGGATGGAAAATCACTAAAGCCTGACAGTGTCCGG
TCCCAGCTGGAGACGTCATTGAAGAGGCTGCAGTGTCCCCAAGTGGACCTCTTCTACCTA
CACGCACCTGACCACGGCACCCCGGTGGAAGAGACGCTGCATGCCTGCCAGCGGCTGCAC
CAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCTAGCTGGGAAGTGGCCGAG
ATCTGTACCCTCTGCAAGAGCAATGGCTGGATCCTGCCCACTGTGTACCAGGGCATGTAC
AACGCCACCACCCGGCAGGTGGAAACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTG
AGGTTCTATGCCTACAACCCTCTGGCTGGGGGCCTGCTGACTGGCAAGTACAAGTATGAG
GACAAGGACGGGAAACAGCCTGTGGGCCGCTTCTTTGGGAATAGCTGGGCTGAGACCTAC
AGGAATCGCTTCTGGAAGGAGCACCACTTCGAGGCCATTGCGTTGGTGGAGAAGGCCCTG
CAGGCCGCATATGGCGCCAGCGCCCCCAGTGTGACCTCGGCTGCCCTCCGGTGGATGTAC
CACCACTCACAGCTGCAGGGTGCCCACGGGGACGCGGTCATCCTGGGCATGTCCAGCCTG
GAGCAGCTGGAGCAGAACTTGGCAGCAACAGAGGAAGGGCCCCTGGAGCCGGCTGTCGTG
GATGCCTTTAATCAAGCCTGGCATTTGGTTGCTCACGAATGTCCCAACTACTTCCGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 359 |
| Molecular Weight
| 39588.65 |
| Theoretical pI
| 7.171 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aflatoxin B1 aldehyde reductase member 2
MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV
RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR
SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE
ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE
DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY
HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR
|
| External Links |
|---|
| GenBank ID Protein
| 41327764 |
| UniProtKB/Swiss-Prot ID
| O43488 |
| UniProtKB/Swiss-Prot Entry Name
| ARK72_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_003689.2 |
| GeneCard ID
| AKR7A2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:389 |
| References |
|---|
| General References
| Not Available |