| Identification |
|---|
| HMDB Protein ID
| CDBP02290 |
| Secondary Accession Numbers
| Not Available |
| Name
| Inositol-trisphosphate 3-kinase C |
| Description
| Not Available |
| Synonyms
|
- IP3 3-kinase C
- IP3K C
- Inositol 1,4,5-trisphosphate 3-kinase C
- InsP 3-kinase C
|
| Gene Name
| ITPKC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in inositol trisphosphate 3-kinase activity |
| Specific Function
| Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity).
|
| GO Classification
|
| Cellular Component |
| cytoplasm |
| nucleus |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| inositol or phosphatidylinositol kinase activity |
| inositol trisphosphate kinase activity |
| inositol trisphosphate 3-kinase activity |
| Molecular Function |
| ATP binding |
| inositol-1,4,5-trisphosphate 3-kinase activity |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Calcium signaling pathway | Not Available |  | | Phosphatidylinositol signaling system | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.1 |
| SNPs
| ITPKC |
| Gene Sequence
|
>2052 bp
ATGAGGCGCTGCCCGTGCCGTGGGAGCCTGAACGAGGCGGAGGCCGGGGCGCTGCCCGCG
GCGGCCCGCATGGGACTGGAGGCGCCGCGAGGAGGGCGGCGGCGGCAGCCGGGACAGCAG
CGACCTGGGCCCGGCGCAGGGGCCCCGGCGGGGCGGCCGGAGGGGGGCGGGCCCTGGGCC
CGGACAGAGGGGTCCAGCCTCCACAGCGAGCCTGAGAGGGCCGGCCTCGGGCCTGCGCCG
GGGACAGAGAGTCCGCAGGCAGAATTCTGGACAGACGGACAGACTGAGCCCGCGGCAGCT
GGCCTTGGAGTAGAGACCGAGAGGCCCAAGCAAAAGACGGAGCCAGACAGGTCCAGCCTC
CGGACGCATCTAGAATGGAGCTGGTCAGAGCTGGAGACGACTTGTCTTTGGACGGAGACC
GGGACAGATGGCCTTTGGACTGATCCGCACAGGTCCGACCTCCAGTTTCAGCCCGAGGAG
GCCAGCCCCTGGACACAGCCAGGGGTTCATGGGCCCTGGACAGAGCTGGAAACGCATGGG
TCACAGACTCAGCCAGAGAGGGTCAAGTCCTGGGCTGATAACCTCTGGACCCACCAGAAC
AGTTCCAGCCTCCAGACTCACCCAGAAGGAGCCTGTCCCTCAAAAGAGCCAAGTGCTGAT
GGCTCCTGGAAAGAATTGTATACTGATGGCTCCAGGACACAACAGGATATTGAAGGTCCC
TGGACAGAGCCATATACTGATGGCTCCCAGAAAAAACAGGATACTGAAGCAGCCAGGAAA
CAGCCTGGCACTGGTGGTTTCCAAATACAACAGGATACTGATGGCTCCTGGACACAACCT
AGCACTGACGGTTCCCAGACAGCACCTGGGACAGACTGCCTCTTGGGAGAGCCTGAGGAT
GGCCCATTAGAGGAACCAGAGCCTGGAGAATTGCTGACTCACCTGTACTCTCACCTGAAG
TGTAGCCCCCTGTGCCCTGTGCCCCGCCTCATCATTACCCCTGAGACCCCTGAGCCTGAG
GCCCAGCCAGTGGGACCCCCCTCCCGGGTTGAGGGGGGCAGCGGCGGCTTCTCCTCTGCC
TCTTCTTTCGACGAGTCTGAGGATGACGTGGTGGCCGGGGGCGGAGGTGCCAGCGATCCC
GAGGACAGGTCTGGGAGCAAACCCTGGAAGAAGCTGAAGACAGTTCTGAAGTATTCACCC
TTTGTGGTCTCCTTCCGAAAACACTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAAC
TTCCAGGCAGGAGAGGATGGTCGGATTCTGAAACGTTTCTGTCAGTGTGAGCAGCGCAGC
CTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTCGTGCCTGCCTACTATGGCATGGTG
CTGCAGGATGGCCAGACCTTCAACCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCC
TCCATTATGGACTGCAAGATGGGCAGCAGGACCTATCTGGAAGAGGAGCTAGTGAAGGCA
CGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAGAAGATGGTGGCTGTGGACCCTGGG
GCCCCTACCCCTGAGGAGCATGCCCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGG
AGGGAAACCATGAGCTCCACCTCTACCCTGGGCTTCCGGATCGAGGGCATCAAGAAGGCA
GATGGGACCTGTAACACCAACTTCAAGAAGACGCAGGCACTGGAGCAGGTGACAAAAGTG
CTGGAGGACTTCGTGGATGGAGACCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAA
GAACTTCGTGAAGCTCTGGAGATCTCCCCCTTCTTCAAGACCCACGAGGTGGTAGGCAGC
TCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCCAAGGTCTGGATGATAGACTTCGGC
AAGACGGTGGCCTTGCCCGACCACCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGC
AACCGTGAGGACGGCTACCTCTGGGGCCTGGACAACATGATCTGCCTCCTGCAGGGGCTG
GCACAGAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 683 |
| Molecular Weight
| 75207.0 |
| Theoretical pI
| 5.139 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inositol-trisphosphate 3-kinase C
MRRCPCRGSLNEAEAGALPAAARMGLEAPRGGRRRQPGQQRPGPGAGAPAGRPEGGGPWA
RTEGSSLHSEPERAGLGPAPGTESPQAEFWTDGQTEPAAAGLGVETERPKQKTEPDRSSL
RTHLEWSWSELETTCLWTETGTDGLWTDPHRSDLQFQPEEASPWTQPGVHGPWTELETHG
SQTQPERVKSWADNLWTHQNSSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQDIEGP
WTEPYTDGSQKKQDTEAARKQPGTGGFQIQQDTDGSWTQPSTDGSQTAPGTDCLLGEPED
GPLEEPEPGELLTHLYSHLKCSPLCPVPRLIITPETPEPEAQPVGPPSRVEGGSGGFSSA
SSFDESEDDVVAGGGGASDPEDRSGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGN
FQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGP
SIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQW
RETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLE
ELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEG
NREDGYLWGLDNMICLLQGLAQS
|
| External Links |
|---|
| GenBank ID Protein
| 14330286 |
| UniProtKB/Swiss-Prot ID
| Q96DU7 |
| UniProtKB/Swiss-Prot Entry Name
| IP3KC_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AJ290975 |
| GeneCard ID
| ITPKC |
| GenAtlas ID
| ITPKC |
| HGNC ID
| HGNC:14897 |
| References |
|---|
| General References
| Not Available |