2288 CDBP02287 Long-chain fatty acid transport protein 1 Q6PCB7 S27A1_HUMAN false true Transporter Homo_sapiens SLC27A1 646 71107.5 8.63 Lipid transport and metabolism Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids ["None"] ["14-34"] NM_198580.1 38524616 SLC27A1 Chromosome:1 19p13.11 true 2020-06-12T23:07:03Z 2020-06-12T23:07:03Z 0 0 0