| Identification |
|---|
| HMDB Protein ID
| CDBP02266 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carbonic anhydrase 4 |
| Description
| Not Available |
| Synonyms
|
- CA-IV
- Carbonate dehydratase IV
- Carbonic anhydrase IV
|
| Gene Name
| CA4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carbonate dehydratase activity |
| Specific Function
| Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
|
| GO Classification
|
| Biological Process |
| bicarbonate transport |
| organ development |
| response to steroid hormone stimulus |
| one-carbon metabolic process |
| small molecule metabolic process |
| response to drug |
| Cellular Component |
| Golgi apparatus |
| perinuclear region of cytoplasm |
| endoplasmic reticulum-Golgi intermediate compartment |
| sarcoplasmic reticulum |
| trans-Golgi network |
| brush border membrane |
| anchored to external side of plasma membrane |
| apical plasma membrane |
| secretory granule membrane |
| transport vesicle membrane |
| rough endoplasmic reticulum |
| sarcolemma |
| Component |
| membrane |
| cell part |
| membrane part |
| plasma membrane |
| intrinsic to membrane |
| anchored to membrane |
| Function |
| hydro-lyase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| carbonate dehydratase activity |
| transition metal ion binding |
| zinc ion binding |
| lyase activity |
| carbon-oxygen lyase activity |
| Molecular Function |
| metal ion binding |
| zinc ion binding |
| carbonate dehydratase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| one-carbon metabolic process |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Proximal tubule bicarbonate reclamation | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q23 |
| SNPs
| CA4 |
| Gene Sequence
|
>939 bp
ATGCGGATGCTGCTGGCGCTCCTGGCCCTCTCCGCGGCGCGGCCATCGGCCAGTGCAGAG
TCACACTGGTGCTACGAGGTTCAAGCCGAGTCCTCCAACTACCCCTGCTTGGTGCCAGTC
AAGTGGGGTGGAAACTGCCAGAAGGACCGCCAGTCCCCCATCAACATCGTCACCACCAAG
GCAAAGGTGGACAAAAAACTGGGACGCTTCTTCTTCTCTGGCTACGATAAGAAGCAAACG
TGGACTGTCCAAAATAACGGGCACTCAGTGATGATGTTGCTGGAGAACAAGGCCAGCATT
TCTGGAGGAGGACTGCCTGCCCCATACCAGGCCAAACAGTTGCACCTGCACTGGTCCGAC
TTGCCATATAAGGGCTCGGAGCACAGCCTCGATGGGGAGCACTTTGCCATGGAGATGCAC
ATAGTACATGAGAAAGAGAAGGGGACATCGAGGAATGTGAAAGAGGCCCAGGACCCTGAA
GACGAAATTGCGGTGCTGGCCTTTCTGGTGGAGGCTGGAACCCAGGTGAACGAGGGCTTC
CAGCCACTGGTGGAGGCACTGTCTAATATCCCCAAACCTGAGATGAGCACTACGATGGCA
GAGAGCAGCCTGTTGGACCTGCTCCCCAAGGAGGAGAAACTGAGGCACTACTTCCGCTAC
CTGGGCTCACTCACCACACCGACCTGCGATGAGAAGGTCGTCTGGACTGTGTTCCGGGAG
CCCATTCAGCTTCACAGAGAACAGATCCTGGCATTCTCTCAGAAGCTGTACTACGACAAG
GAACAGACAGTGAGCATGAAGGACAATGTCAGGCCCCTGCAGCAGCTGGGGCAGCGCACG
GTGATAAAGTCCGGGGCCCCGGGTCGGCCGCTGCCCTGGGCCCTGCCTGCCCTGCTGGGC
CCCATGCTGGCCTGCCTGCTGGCCGGCTTCCTGCGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 312 |
| Molecular Weight
| 35032.075 |
| Theoretical pI
| 7.821 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Carbonic anhydrase 4
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P22748 |
| UniProtKB/Swiss-Prot Entry Name
| CAH4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M83670 |
| GeneCard ID
| CA4 |
| GenAtlas ID
| CA4 |
| HGNC ID
| HGNC:1375 |
| References |
|---|
| General References
| Not Available |