| Identification |
|---|
| HMDB Protein ID
| CDBP02259 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium/potassium/calcium exchanger 1 |
| Description
| Not Available |
| Synonyms
|
- Na(+)/K(+)/Ca(2+)-exchange protein 1
- Retinal rod Na-Ca+K exchanger
|
| Gene Name
| SLC24A1 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in calcium, potassium:sodium antiporter activity |
| Specific Function
| Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| solute:cation antiporter activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| cation transmembrane transporter activity |
| cation:cation antiporter activity |
| calcium:cation antiporter activity |
| calcium, potassium:sodium antiporter activity |
| transporter activity |
| Process |
| calcium ion transport |
| multicellular organismal process |
| system process |
| neurological system process |
| sensory perception |
| sensory perception of light stimulus |
| visual perception |
| establishment of localization |
| transport |
| transmembrane transport |
| ion transport |
| cation transport |
| di-, tri-valent inorganic cation transport |
| divalent metal ion transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q22 |
| SNPs
| SLC24A1 |
| Gene Sequence
|
>3300 bp
ATGGGGAAATTGATCAGGATGGGGCCGCAAGAGAGGTGGTTACTCCGGACAAAGCGGCTT
CATTGGAGTCGCCTCCTCTTCTTACTGGGAATGTTGATCATCGGTTCTACTTATCAGCAC
CTTAGGAGACCCCGGGGCCTTTCCTCATTGTGGGCAGCAGTCTCTTCTCATCAGCCTATA
AAACTGGCCAGTCGGGACCTCTCCAGTGAAGAGATGATGATGATGAGCAGCAGCCCTTCA
AAACCTAGCTCCGAAATGGGGGGTAAGATGCTGGTACCCCAAGCCTCAGTGGGCAGTGAT
GAAGCAACACTGAGCATGACAGTGGAGAATATCCCCAGTATGCCTAAAAGAACAGCCAAG
ATGATCCCAACAACAACCAAGAATAATTACAGCCCAACAGCAGCAGGTACAGAAAGAAGG
AAGGAAGACACCCCAACATCCAGTAGAACACTGACTTACTACACCTCAACTTCAAGCAGA
CAAATAGTAAAAAAGTATACCCCAACACCCAGGGGAGAAATGAAGAGCTACAGCCCAACT
CAAGTGAGGGAAAAGGTGAAGTATACTCCTTCCCCACGTGGTAGAAGAGTAGGCACTTAC
GTGCCGTCCACATTCATGACAATGGAAACAAGCCATGCGATCACCCCCAGGACAACAGTG
AAAGACAGTGACATTACAGCAACCTATAAAATACTCGAAACCAACTCTCTTAAGAGAATA
ATGGAGGAAACCACCCCAACCACTCTCAAGGGAATGTTTGATAGCACCCCAACTTTTCTG
ACACATGAGGTAGAAGCAAACGTCTTGACTTCTCCAAGGAGCGTCATGGAAAAAAACAAC
CTGTTTCCCCCCAGAAGAGTGGAAAGTAACAGCTCAGCCCATCCCTGGGGGTTAGTGGGA
AAGAGCAACCCGAAGACTCCCCAGGGAACAGTCCTGTTGCATACCCCAGCCACCTCTGAG
GGGCAGGTGACAATAAGCACCATGACAGGCAGCAGCCCAGCAGAAACCAAAGCCTTCACT
GCTGCCTGGAGTCTTAGGAATCCTTCACCCAGGACCAGTGTATCAGCCATCAAAACAGCC
CCAGCCATAGTCTGGAGGCTGGCAAAGAAACCTTCCACAGCACCCAGCACCTCAACAACC
CCTACGGTCAGGGCAAAGCTGACCATGCAGGTCCATCACTGTGTGGTTGTGAAGCCAACC
CCAGCCATGCTCACCACTCCCTCCCCAAGCCTCACAACAGCCCTGCTCCCAGAGGAGCTC
AGTCCTAGTCCCTCAGTGCTGCCTCCCAGCTTGCCAGACCTCCACCCCAAGGGAGAGTAC
CCCCCAGATCTGTTCAGTGTGGAGGAGCGGCGGCAGGGCTGGGTGGTCCTGCACGTTTTT
GGCATGATGTATGTGTTTGTGGCCTTGGCCATTGTTTGCGACGAGTACTTCGTTCCAGCC
CTGGGTGTCATCACAGACAAGCTGCAGATCTCCGAGGATGTGGCAGGCGCCACATTCATG
GCTGCTGGAGGCTCTGCTCCTGAGCTCTTCACCTCCCTCATCGGTGTCTTCATTTCCCAC
AGCAACGTGGGCATTGGTACCATTGTGGGCTCTGCTGTGTTCAACATTCTCTTTGTCATT
GGCACTTGTTCCCTCTTCTCCCGAGAGATCCTCAACCTCACCTGGTGGCCCTTATTCCGT
GATGTCTCCTTCTACATCCTTGACCTGATAATGCTCATCCTCTTCTTCCTGGACAGCCTC
ATTGCCTGGTGGGAGAGCCTGCTGCTGCTGCTGGCCTATGCCTTCTATGTGTTCACCATG
AAGTGGAACAAGCATATCGAGGTCTGGGTGAAGGAGCAGCTCAGCAGGAGGCCAGTGGCC
AAGGTCATGGCCTTAGAAGACCTCAGCAAGCCGGGCGATGGGGCCATTGCGGTGGATGAG
CTACAGGATAACAAGAAGCTGAAGCTCCCGTCCTTGCTGACCCGAGGGAGCAGCTCGACC
TCTCTGCACAACAGCACCATCCGCAGCACCATCTACCAGCTCATGCTCCACAGCCTGGAC
CCCCTGAGGGAAGTTCGCCTTGCCAAGGAGAAGGAGGAGGAGAGCTTGAATCAAGGGGCC
AGAGCCCAACCCCAGGCCAAAGCAGAAAGCAAACCAGAAGAGGAGGAGCCAGCCAAGCTC
CCTGCGGTCACGGTCACACCAGCCCCTGTTCCAGACATCAAGGGAGATCAGAAGGAGAAT
CCAGGCGGTCAGGAAGATGTGGCTGAGGCCGAGAGCACAGGTGAAATGCCAGGCGAAGAG
GGCGAAACTGCTGGTGAAGGTGAAACTGAAGAGAAAAGTGGAGGTGAAACTCAACCAGAA
GGTGAAGGTGAAACTGAAACACAAGGAAAAGGAGAAGAATGTGAAGATGAAAATGAAGCA
GAAGGAAAAGGAGACAATGAAGGTGAAGATGAGGGTGAAATCCACGCAGAAGATGGTGAA
ATGAAAGGTAATGAAGGTGAAACTGAAAGCCAGGAACTCAGTGCTGAAAATCACGGTGAA
GCCAAAAATGATGAGAAAGGTGTAGAAGATGGAGGGGGAAGTGATGGAGGGGATAGCGAA
GAGGAGGAAGAGGAGGAGGAAGAGCAGGAGGAAGAGGAGGAGGAGGAAGAGCAGGAGGAA
GAGGAGGAGGAGGAGGAGGAAGAGGAGGAGAAGGGAAATGAAGAGCCTCTGTCCCTGGAC
TGGCCTGAAACCAGGCAGAAGCAGGCCATTTACCTCTTCCTTCTGCCCATCGTGTTCCCA
CTGTGGCTGACAGTCCCCGACGTCCGAAGGCAGGAGTCTAGGAAGTTTTTTGTTTTCACC
TTCCTGGGATCTATCATGTGGATAGCCATGTTCTCATACCTCATGGTGTGGTGGGCTCAC
CAGGTTGGTGAAACAATAGGGATTTCTGAAGAGATCATGGGCCTGACAATCCTTGCAGCA
GGCACATCAATTCCTGACCTCATCACCAGTGTGATTGTCGCTCGAAAAGGCCTGGGAGAC
ATGGCTGTGTCAAGCTCTGTGGGCAGTAACATATTTGATATCACTGTGGGCTTGCCTGTT
CCTTGGTTGCTTTTCTCTCTTATCAATGGATTACAGCCAGTTCCAGTCAGCAGCAATGGC
TTGTTTTGTGCAATTGTTTTGCTTTTTCTCATGCTTCTGTTTGTGATCTCTTCAATTGCG
TCATGTAAATGGAGAATGAACAAGATCCTGGGCTTCACAATGTTCCTCCTTTACTTTGTA
TTCCTGATAATCAGTGTGATGTTAGAAGATCGAATCATATCCTGTCCTGTATCTGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1099 |
| Molecular Weight
| 121373.1 |
| Theoretical pI
| 4.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["453-473", "498-518", "523-543", "564-584", "586-606", "908-928", "936-956", "972-992", "1011-1031", "1040-1060", "1069-1089"]
|
| Protein Sequence
|
>Sodium/potassium/calcium exchanger 1
MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPI
KLASRDLSSEEMMMMSSSPSKPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAK
MIPTTTKNNYSPTAAGTERRKEDTPTSSRTLTYYTSTSSRQIVKKYTPTPRGEMKSYSPT
QVREKVKYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLKRI
MEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVG
KSNPKTPQGTVLLHTPATSEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTA
PAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVKPTPAMLTTPSPSLTTALLPEEL
SPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPA
LGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVI
GTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTM
KWNKHIEVWVKEQLSRRPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSST
SLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKL
PAVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPE
GEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGE
AKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLD
WPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAH
QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPV
PWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFV
FLIISVMLEDRIISCPVSV
|
| External Links |
|---|
| GenBank ID Protein
| 4759128 |
| UniProtKB/Swiss-Prot ID
| O60721 |
| UniProtKB/Swiss-Prot Entry Name
| NCKX1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004727.2 |
| GeneCard ID
| SLC24A1 |
| GenAtlas ID
| SLC24A1 |
| HGNC ID
| HGNC:10975 |
| References |
|---|
| General References
| Not Available |