Showing Protein Sodium/potassium/calcium exchanger 4 (CDBP02214)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02214
Secondary Accession Numbers Not Available
Name Sodium/potassium/calcium exchanger 4
Description Not Available
Synonyms
  1. Na(+)/K(+)/Ca(2+)-exchange protein 4
  2. Solute carrier family 24 member 4
Gene Name SLC24A4
Protein Type Enzyme
Biological Properties
General Function Involved in transmembrane transport
Specific Function Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 14q32.12
SNPs SLC24A4
Gene Sequence 
>1818 bp
ATGCTGCCGCAGCAAGTCGGCTTCGTGTGCGCGGTGCTGGCCCTGGTGTGCTGTGCGTCC
GGCCTCTTCGGCAGCTTGGGGCACAAAACAGCTTCTGCTAGCAAACGTGTCCTGCCAGAC
ACATGGAGAAATAGAAAGTTGATGGCCCCAGTGAATGGGACACAGACAGCCAAGAACTGC
ACAGATCCTGCGATTCACGAGTTCCCCACAGATCTGTTCTCCAATAAGGAGCGACAGCAC
GGAGCCGTCCTGCTGCACATCCTTGGTGCTCTGTATATGTTCTATGCCTTGGCCATAGTG
TGCGATGACTTCTTTGTTCCGTCTCTAGAGAAGATCTGTGAGAGACTCCATCTGAGCGAA
GATGTGGCTGGAGCCACCTTCATGGCTGCAGGAAGCTCAACGCCAGAGCTGTTTGCGTCT
GTTATTGGGGTGTTCATCACCCATGGGGACGTCGGGGTGGGCACCATCGTGGGCTCTGCT
GTGTTCAACATCCTGTGCATAATTGGAGTGTGCGGACTGTTTGCTGGCCAGGTGGTCCGT
CTGACGTGGTGGGCCGTGTGCCGAGACTCCGTGTACTACACCATCTCTGTCATCGTGCTC
ATCGTGTTCATATATGATGAACAAATTGTGTGGTGGGAAGGCCTGGTGCTCATCATCTTG
TATGTGTTTTATATTCTGATCATGAAGTACAATGTGAAGATGCAAGCCTTTTTCACAGTC
AAACAAAAGAGCATTGCAAACGGTAACCCGGTCAACAGTGAGCTGGAGGCTGGTAATGAT
TTCTATGACGGTAGCTATGATGACCCTTCCGTGCCATTGCTGGGGCAAGTGAAGGAGAAG
CCACAGTATGGCAAGAACCCCGTGGTGATGGTGGACGAGATTATGAGCTCCAGCCCTCCC
AAGTTCACCTTCCCTGAAGCAGGCTTACGAATCATGATCACCAATAAGTTTGGACCCAGG
ACCCGACTACGGATGGCCAGCAGGATCATCATTAATGAGCGGCAGAGACTGATCAACTCG
GCCAATGGTGTGAGCAGTAAGCCGCTTCAAAACGGGAGGCACGAGAACATTGAGAACGGG
AATGTTCCTGTGGAAAACCCCGAAGACCCTCAGCAGAATCAGGAGCAGCAGCCGCCGCCA
CAGCCACCACCGCCAGAGCCAGAGCCGGTGGAGGCTGACTTCCTGTCCCCCTTCTCCGTG
CCGGAGGCCAGAGGGGACAAGGTCAAGTGGGTGTTCACCTGGCCCCTCATCTTCCTCCTG
TGCGTCACCATTCCCAACTGCAGCAAGCCCCGCTGGGAGAAGTTCTTCATGGTCACCTTC
ATCACCGCCACGCTGTGGATCGCTGTGTTCTCCTACATCATGGTGTGGCTGGTGACTATT
ATCGGATACACACTTGGGATCCCGGATGTCATCATGGGCATTACTTTCCTGGCAGCAGGG
ACAAGTGTTCCAGACTGCATGGCCAGCCTAATTGTGGCGAGACAAGGCCTTGGGGACATG
GCAGTCTCCAACACCATAGGAAGCAACGTGTTTGACATCCTGGTAGGACTTGGTGTACCG
TGGGGCCTGCAGACCATGGTTGTTAATTATGGATCAACAGTGAAGATCAACAGCCGGGGG
CTGGTCTATTCCGTGGTCCTGTTGCTGGGCTCTGTCGCTCTCACCGTCCTCGGCATCCAC
CTAAACAAGTGGCGACTGGACCGGAAGCTGGGTGTCTACGTGCTGGTTCTCTACGCCATC
TTCTTGTGCTTCTCCATAATGATAGAGTTTAACGTCTTTACCTTCGTCAACTTGCCGATG
TGCCGGGAAGACGATTAG
Protein Properties
Number of Residues 605
Molecular Weight 66950.8
Theoretical pI 6.31
Pfam Domain Function
Signals
  • ["1-21"]
Transmembrane Regions
  • ["81-101", "156-176", "184-204", "208-228", "408-428", "441-461", "463-483", "510-530", "541-561", "570-590"]
Protein Sequence 
>Sodium/potassium/calcium exchanger 4
MLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC
TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSE
DVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVR
LTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTV
KQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPP
KFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENG
NVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLL
CVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAG
TSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG
LVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPM
CREDD
GenBank ID Protein 21702721
UniProtKB/Swiss-Prot ID Q8NFF2
UniProtKB/Swiss-Prot Entry Name NCKX4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF520704
GeneCard ID SLC24A4
GenAtlas ID SLC24A4
HGNC ID HGNC:10978
References
General References Not Available