Identification
HMDB Protein ID CDBP02207
Secondary Accession Numbers Not Available
Name Myotubularin-related protein 3
Description Not Available
Synonyms
  1. FYVE domain-containing dual specificity protein phosphatase 1
  2. FYVE-DSP1
  3. Zinc finger FYVE domain-containing protein 10
Gene Name MTMR3
Protein Type Metal Binding
Biological Properties
General Function Involved in phosphatase activity
Specific Function Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues.
GO Classification
Biological Process
small molecule metabolic process
phosphatidylinositol biosynthetic process
phosphatidylinositol dephosphorylation
Cellular Component
cytosol
nucleus
membrane
Function
hydrolase activity
transition metal ion binding
zinc ion binding
phosphoric ester hydrolase activity
phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
ion binding
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
Molecular Function
protein serine/threonine phosphatase activity
metal ion binding
phosphatidylinositol-3-phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Membrane
Pathways
Gene Properties
Chromosome Location 22
Locus 22q12.2
SNPs MTMR3
Gene Sequence
>3597 bp
ATGGATGAAGAGACTCGGCACAGCCTTGAGTGCATCCAGGCCAATCAGATCTTTCCCAGG
AAGCAGCTGATCCGGGAGGATGAGAATCTTCAGGTTCCTTTCCTTGAACTTCATGGAGAG
AGCACAGAGTTTGTGGGCCGTGCCGAGGATGCCATCATTGCCCTTTCCAATTACAGACTT
CACATCAAGTTCAAGGAGTCTCTTGTTAATGTTCCATTACAGCTTATAGAAAGTGTTGAA
TGCCGAGATATATTTCAGCTTCATTTGACTTGCAAAGACTGCAAAGTTATCAGGTGTCAG
TTTTCAACCTTTGAGCAGTGTCAAGAGTGGCTGAAGAGACTGAACAACGCAATCCGACCA
CCTGCTAAAATAGAAGATCTCTTCTCATTTGCATACCATGCTTGGTGCATGGAGGTCTAT
GCCAGTGAAAAAGAGCAACATGGAGACCTGTGCAGACCAGGGGAGCATGTAACTTCAAGG
TTTAAAAACGAGGTGGAGAGGATGGGTTTTGATATGAACAACGCCTGGAGGATTTCCAAC
ATCAATGAGAAGTACAAATTATGTGGTAGCTATCCTCAAGAGCTCATAGTGCCTGCCTGG
ATCACTGACAAAGAACTGGAAAGTGTATCAAGTTTCAGGTCCTGGAAGCGCATCCCTGCC
GTCATCTACAGGCACCAGAGCAATGGAGCTGTCATTGCCCGCTGTGGACAGCCAGAGGTT
AGCTGGTGGGGCTGGCGAAATGCAGATGATGAGCATCTGGTACAGTCAGTAGCCAAAGCT
TGTGCCTCTGACTCCCGATCGAGTGGCAGCAAGCTGTCAACTAGGAACACTTCTCGAGAC
TTTCCCAATGGGGGAGACCTTTCTGACGTGGAGTTCGATTCTTCTCTGTCAAATGCTTCA
GGAGCAGAGAGTTTAGCCATCCAACCGCAGAAGCTTTTGATCTTGGATGCACGCTCCTAT
GCAGCTGCTGTGGCAAACCGAGCCAAAGGAGGAGGCTGCGAATGCCCAGAGTATTACCCA
AACTGTGAAGTTGTGTTTATGGGGATGGCAAACATTCATTCTATTCGGAGGAGTTTTCAG
TCTCTGCGGTTGCTGTGCACTCAGATGCCAGATCCGGGAAATTGGCTATCAGCTCTTGAA
AGCACAAAATGGCTCCATCACTTGTCTGTGCTTCTGAAATCAGCGCTTCTGGTAGTGCAT
GCTGTGGATCAGGATCAGCGGCCGGTGCTAGTACACTGCTCAGATGGCTGGGACCGCACC
CCCCAGATTGTGGCATTGGCTAAGCTCTTGCTGGACCCTTATTACCGAACCATAGAGGGT
TTCCAGGTCCTCGTGGAAATGGAGTGGCTGGATTTTGGCCATAAATTTGCTGACCGGTGT
GGTCATGGGGAGAACTCGGATGATCTGAATGAACGTTGCCCAGTGTTTCTGCAGTGGCTT
GACTGTGTTCATCAGCTTCAGAGGCAATTTCCTTGCTCTTTTGAGTTCAATGAAGCATTC
CTTGTGAAACTGGTGCAGCATACCTATTCCTGCCTGTTTGGAACATTCCTGTGCAACAAC
GCCAAGGAGAGAGGGGAAAAGCATACTCAGGAACGGACATGTTCCGTGTGGTCACTTCTT
CGGGCAGGCAACAAGGCTTTCAAAAACCTACTGTATTCCTCTCAGTCAGAAGCCGTGCTG
TACCCTGTGTGCCATGTGCGTAACCTGATGCTGTGGAGTGCAGTGTACCTGCCCTGCCCA
TCCCCAACCACCCCTGTGGACGACAGCTGTGCACCATACCCAGCCCCAGGCACCAGCCCT
GATGATCCCCCCCTGAGCCGGCTACCAAAGACTAGATCATACGACAATCTGACCACAGCC
TGTGACAACACAGTGCCTCTGGCCAGCCGGCGCTGCAGCGACCCCAGCCTGAACGAGAAG
TGGCAGGAGCACCGGCGCTCACTAGAGCTGAGCAGCCTGGCTGGCCCTGGAGAGGATCCC
CTTTCTGCCGACAGCCTAGGGAAGCCCACCAGAGTGCCGGGGGGTGCCGAGCTTTCTGTT
GCAGCCGGAGTAGCTGAGGGGCAGATGGAGAACATCTTGCAGGAGGCCACCAAAGAGGAG
AGTGGAGTAGAGGAACCTGCCCACAGGGCAGGCATTGAGATACAGGAGGGTAAAGAGGAC
CCTCTCTTAGAAAAGGAGAGCAGGAGGAAGACACCTGAGGCCTCAGCCATTGGACTTCAC
CAAGACCCAGAACTGGGTGATGCTGCTCTGAGGAGCCATCTGGATATGAGCTGGCCTCTG
TTCTCACAGGGCATTTCTGAACAGCAGAGTGGGCTCAGTGTTCTCCTCAGTTCTCTCCAG
GTCCCCCCCAGGGGAGAGGATTCCCTGGAGGTCCCTGTGGAGCAGTTTCGAATAGAAGAG
ATTGCAGAGGGTAGGGAGGAAGCAGTTCTTCCAATCCCAGTAGATGCAAAAGTTGGCTAT
GGTACCTCACAGTCATGTTCTCTGCTACCTTCCCAAGTCCCTTTTGAGACCAGAGGACCA
AACGTGGACAGTTCTACAGACATGTTAGTGGAAGATAAGGTGAAGTCAGTAAGTGGGCCC
CAAGGTCATCATAGATCTTGCCTTGTAAATAGTGGCAAGGACAGGCTTCCTCAGACCATG
GAACCCAGCCCTTCAGAGACAAGCCTGGTCGAGAGGCCCCAAGTGGGGTCTGTGGTGCAT
AGGACTTCCCTTGGCAGCACTCTCAGCCTGACACGTTCCCCTTGTGCCTTGCCTTTAGCC
GAATGTAAAGAGGGGCTTGTGTGCAATGGTGCCCCAGAGACTGAAAACAGGGCCTCAGAG
CAGCCCCCAGGTCTTAGCACCCTCCAGATGTACCCCACACCCAATGGGCATTGCGCCAAT
GGGGAGGCTGGTAGGAGCAAGGACTCACTGAGCCGTCAGCTGTCTGCTATGAGCTGCAGC
TCTGCCCACTTACACTCAAGGAACTTGCACCACAAGTGGCTGCATAGCCACTCAGGAAGG
CCATCTGCAACCAGCAGCCCCGACCAGCCTTCCCGCAGCCACCTGGACGATGATGGCATG
TCAGTGTACACAGACACGATCCAACAGCGCCTGCGTCAGATTGAGTCAGGCCACCAGCAG
GAAGTAGAAACTTTGAAGAAACAAGTCCAGGAGCTGAAGAGTCGCCTGGAGAGCCAGTAC
CTGACCAGCTCCCTACACTTTAATGGAGACTTTGGGGATGAGGTGACTTCAATCCCCGAC
TCGGAAAGCAATCTGGATCAGAACTGTTTGTCTCGCTGCAGCACAGAGATTTTCTCTGAA
GCCAGCTGGGAGCAGGTGGATAAACAGGACACAGAGATGACCCGTTGGCTTCCTGACCAC
CTGGCCGCCCACTGCTATGCGTGCGACAGTGCCTTCTGGCTTGCCAGCAGGAAGCACCAC
TGCAGGAATTGTGGGAACGTATTCTGCTCCAGTTGTTGTAACCAGAAGGTTCCAGTTCCC
AGCCAGCAGCTCTTTGAACCCAGTCGAGTATGCAAGTCTTGCTATAGCAGCCTACATCCC
ACAAGCTCCAGCATTGACCTTGAACTGGATAAGCCCATTGCTGCCACTTCCAACTGA
Protein Properties
Number of Residues 1198
Molecular Weight 133617.635
Theoretical pI 5.8
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Myotubularin-related protein 3
MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPD
SESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHH
CRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
GenBank ID Protein 10835109
UniProtKB/Swiss-Prot ID Q13615
UniProtKB/Swiss-Prot Entry Name MTMR3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_021090.3
GeneCard ID MTMR3
GenAtlas ID MTMR3
HGNC ID HGNC:7451
References
General References Not Available