| Identification |
|---|
| HMDB Protein ID
| CDBP02194 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peroxiredoxin-2 |
| Description
| Not Available |
| Synonyms
|
- NKEF-B
- Natural killer cell-enhancing factor B
- PRP
- TSA
- Thiol-specific antioxidant protein
- Thioredoxin peroxidase 1
- Thioredoxin-dependent peroxide reductase 1
|
| Gene Name
| PRDX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in antioxidant activity |
| Specific Function
| Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
|
| GO Classification
|
| Biological Process |
| negative regulation of apoptotic process |
| removal of superoxide radicals |
| hydrogen peroxide catabolic process |
| Cellular Component |
| cytoplasm |
| Function |
| peroxiredoxin activity |
| catalytic activity |
| antioxidant activity |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| oxidoreductase activity |
| Molecular Function |
| thioredoxin peroxidase activity |
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.2 |
| SNPs
| PRDX2 |
| Gene Sequence
|
>597 bp
ATGGCCTCCGGTAACGCGCGCATCGGAAAGCCAGCCCCTGACTTCAAGGCCACAGCGGTG
GTTGATGGCGCCTTCAAAGAGGTGAAGCTGTCGGACTACAAAGGGAAGTACGTGGTCCTC
TTTTTCTACCCTCTGGACTTCACTTTTGTGTGCCCCACCGAGATCATCGCGTTCACAACC
GTGAAGAGGACTTCCGCAAAGCTGGGCTGTGAAGTGCTGGGCGTCTCGGTGGACTCTCAG
TTCACCCACCTGGCTTGGATCAACACCCCCCGGAAAGAGGGAGGCTTGGGCCCCTTGAAC
ATCCCCCTGCTTGCTGACGTGACCAGACGCTTGTCTGAGGATTACGGCGTGCTGAAAAAC
GATGAGGGCATTGCTTACAGGGGCCTCTTTATCATCGATGGCAAGGGTGTCCTTCGCCAG
ATCACTGTTAATGATTTGCCTGTGGGACGCTCCGTGGATGAGGCTCTGCGGCTGGTCCAG
GCCTTCCAGTACACAGACGAGCATGGGGAAGTTTGTCCGGCTGCTTGGAAGCCTGGACGT
GACACGATTAAGCCGAACGTGGATGACAGCAAGGAATATTTCTCCAAACACAATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 198 |
| Molecular Weight
| 21891.725 |
| Theoretical pI
| 5.972 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxiredoxin-2
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSN
RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT
DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS
DTIKPNVDDSKEYFSKHN
|
| External Links |
|---|
| GenBank ID Protein
| 438069 |
| UniProtKB/Swiss-Prot ID
| P32119 |
| UniProtKB/Swiss-Prot Entry Name
| PRDX2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Z22548 |
| GeneCard ID
| PRDX2 |
| GenAtlas ID
| PRDX2 |
| HGNC ID
| HGNC:9353 |
| References |
|---|
| General References
| Not Available |