| Identification |
|---|
| HMDB Protein ID
| CDBP02186 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peroxiredoxin-1 |
| Description
| Not Available |
| Synonyms
|
- NKEF-A
- Natural killer cell-enhancing factor A
- PAG
- Proliferation-associated gene protein
- Thioredoxin peroxidase 2
- Thioredoxin-dependent peroxide reductase 2
|
| Gene Name
| PRDX1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in antioxidant activity |
| Specific Function
| Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
|
| GO Classification
|
| Biological Process |
| natural killer cell mediated cytotoxicity |
| regulation of NF-kappaB import into nucleus |
| regulation of stress-activated MAPK cascade |
| cell proliferation |
| skeletal system development |
| removal of superoxide radicals |
| hydrogen peroxide catabolic process |
| erythrocyte homeostasis |
| Cellular Component |
| mitochondrion |
| nucleus |
| melanosome |
| Function |
| catalytic activity |
| antioxidant activity |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| oxidoreductase activity |
| peroxiredoxin activity |
| Molecular Function |
| thioredoxin peroxidase activity |
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- Cytoplasm
- Melanosome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Peroxisome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p34.1 |
| SNPs
| PRDX1 |
| Gene Sequence
|
>600 bp
ATGTCTTCAGGAAATGCTAAAATTGGGCACCCTGCCCCCAACTTCAAAGCCACAGCTGTT
ATGCCAGATGGTCAGTTTAAAGATATCAGCCTGTCTGACTACAAAGGAAAATATGTTGTG
TTCTTCTTTTACCCTCTTGACTTCACCTTTGTGTGCCCCACGGAGATCATTGCTTTCAGT
GATAGGGCAGAAGAATTTAAGAAACTCAACTGCCAAGTGATTGGTGCTTCTGTGGATTCT
CACTTCTGTCATCTAGCATGGGTCAATACACCTAAGAAACAAGGAGGACTGGGACCCATG
AACATTCCTTTGGTATCAGACCCGAAGCGCACCATTGCTCAGGATTATGGGGTCTTAAAG
GCTGATGAAGGCATCTCGTTCAGGGGCCTTTTTATCATTGATGATAAGGGTATTCTTCGG
CAGATCACTGTAAATGACCTCCCTGTTGGCCGCTCTGTGGATGAGACTTTGAGACTAGTT
CAGGCCTTCCAGTTCACTGACAAACATGGGGAAGTGTGCCCAGCTGGCTGGAAACCTGGC
AGTGATACCATCAAGCCTGATGTCCAAAAGAGCAAAGAATATTTCTCCAAGCAGAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 199 |
| Molecular Weight
| 22110.19 |
| Theoretical pI
| 8.132 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxiredoxin-1
MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
DRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLK
ADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPG
SDTIKPDVQKSKEYFSKQK
|
| External Links |
|---|
| GenBank ID Protein
| 197692225 |
| UniProtKB/Swiss-Prot ID
| Q06830 |
| UniProtKB/Swiss-Prot Entry Name
| PRDX1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB451262 |
| GeneCard ID
| PRDX1 |
| GenAtlas ID
| PRDX1 |
| HGNC ID
| HGNC:9352 |
| References |
|---|
| General References
| Not Available |