Showing Protein Sodium-dependent phosphate transport protein 4 (CDBP02176)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP02176
Secondary Accession Numbers Not Available
Name Sodium-dependent phosphate transport protein 4
Description Not Available
Synonyms
  1. Na(+)/PI cotransporter 4
  2. Sodium/phosphate cotransporter 4
  3. Solute carrier family 17 member 3
Gene Name SLC17A3
Protein Type Transporter
Biological Properties
General Function Involved in transmembrane transport
Specific Function Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
GO Classification
Biological Process
glucose-6-phosphate transport
urate metabolic process
urate transport
Cellular Component
endoplasmic reticulum membrane
perinuclear region of cytoplasm
brush border membrane
apical plasma membrane
integral to plasma membrane
Molecular Function
sodium:phosphate symporter activity
efflux transmembrane transporter activity
organic anion transmembrane transporter activity
toxin transporter activity
urate transmembrane transporter activity
voltage-gated anion channel activity
drug transmembrane transporter activity
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location 6
Locus 6p21.3
SNPs SLC17A3
Gene Sequence 
>1263 bp
ATGGCCACCAAGACAGAGTTGAGTCCCACAGCAAGGGAGAGCAAGAACGCACAAGATATG
CAAGTGGATGAGACACTGATCCCCAGGAAAGTTCCAAGTTTATGTTCTGCTCGCTATGGA
ATAGCCCTCGTCTTACATTTCTGCAATTTCACAACGATAGCACAAAATGTCATCATGAAC
ATCACCATGGTAGCCATGGTCAACAGCACAAGCCCTCAATCCCAGCTCAATGATTCCTCT
GAGGTGCTGCCTGTTGACTCATTTGGTGGCCTAAGTAAAGCCCCAAAGAGTCTTCCTGCA
AAGTCCTCAATACTTGGGGGTCAGTTTGCAATTTGGGAAAAGTGGGGCCCTCCACAAGAA
CGAAGCAGACTCTGCAGCATTGCTTTATCAGGAATGTTACTGGGATGCTTTACTGCCATC
CTCATAGGTGGCTTCATTAGTGAAACCCTTGGGTGGCCCTTTGTCTTCTATATCTTTGGA
GGTGTTGGCTGTGTCTGCTGCCTTCTCTGGTTTGTTGTGATTTATGATGACCCCGTTTCC
TATCCATGGATAAGCACCTCAGAAAAAGAATACATCATATCCTCCTTGAAACAACAGGTC
GGGTCTTCTAAGCAGCCTCTTCCCATCAAAGCTATGCTCAGATCTCTACCCATTTGGTCC
ATATGTTTAGGCTGTTTCAGCCATCAATGGTTAGTTAGCACAATGGTTGTATACATACCA
ACTTACATCAGCTCTGTGTACCATGTTAACATCAGAGACAATGGACTTCTATCTGCCCTT
CCTTTTATTGTTGCCTGGGTCATAGGCATGGTGGGAGGCTATCTGGCAGATTTCCTTCTA
ACCAAAAAGTTTAGACTCATCACTGTGAGGAAAATTGCCACAATTTTAGGAAGTCTCCCC
TCTTCAGCACTCATTGTGTCTCTGCCTTACCTCAATTCCGGCTATATCACAGCAACTGCC
TTGCTGACGCTCTCTTGCGGATTAAGCACATTGTGTCAGTCAGGGATTTATATCAATGTC
TTAGATATTGCTCCAAGGTATTCCAGTTTTCTCATGGGAGCATCAAGAGGATTTTCGAGC
ATAGCACCTGTCATTGTACCCACTGTCAGTGGATTTCTTCTTAGTCAGGACCCTGAGTTT
GGGTGGAGGAATGTCTTCTTCTTGCTGTTTGCCGTTAACCTGTTAGGACTACTCTTCTAC
CTCATATTTGGAGAAGCAGATGTCCAAGAATGGGCTAAAGAGAGAAAACTCACTCGTTTA
TGA
Protein Properties
Number of Residues 420
Molecular Weight 54258.275
Theoretical pI 8.523
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Sodium-dependent phosphate transport protein 4
MATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMN
ITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQE
RSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVS
YPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIP
TYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLP
SSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSS
IAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL
GenBank ID Protein 11225666
UniProtKB/Swiss-Prot ID O00476
UniProtKB/Swiss-Prot Entry Name NPT4_HUMAN
PDB IDs Not Available
GenBank Gene ID AL138726
GeneCard ID SLC17A3
GenAtlas ID SLC17A3
HGNC ID HGNC:10931
References
General References Not Available