| Identification |
|---|
| HMDB Protein ID
| CDBP02159 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-type lectin domain family 4 member M |
| Description
| Not Available |
| Synonyms
|
- CD209 antigen-like protein 1
- CD299 antigen
- DC-SIGN-related protein
- DC-SIGN2
- DC-SIGNR
- Dendritic cell-specific ICAM-3-grabbing non-integrin 2
- L-SIGN
- Liver/lymph node-specific ICAM-3-grabbing non-integrin
|
| Gene Name
| CLEC4M |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sugar binding |
| Specific Function
| Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus |
| GO Classification
|
| Function |
| binding |
| carbohydrate binding |
| sugar binding |
|
| Cellular Location
|
- Isoform 10:Secreted (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13 |
| SNPs
| CLEC4M |
| Gene Sequence
|
>1200 bp
ATGAGTGACTCCAAGGAACCAAGGGTGCAGCAGCTGGGCCTCCTGGAAGAAGATCCAACA
ACCAGTGGCATCAGACTTTTTCCAAGAGACTTTCAATTCCAGCAGATACATGGCCACAAG
AGCTCTACAGGGTGTCTTGGCCATGGCGCCCTGGTGCTGCAACTCCTCTCCTTCATGCTC
TTGGCTGGGGTCCTGGTGGCCATCCTTGTCCAAGTGTCCAAGGTCCCCAGCTCCCTAAGT
CAGGAACAATCCGAGCAAGACGCAATCTACCAGAACCTGACCCAGCTTAAAGCTGCAGTG
GGTGAGCTCTCAGAGAAATCCAAGCTGCAGGAGATCTACCAGGAGCTGACCCAGCTGAAG
GCTGCAGTGGGTGAGTTGCCAGAGAAATCCAAGCTGCAGGAGATCTACCAGGAGCTGACC
CGGCTGAAGGCTGCAGTGGGTGAGTTGCCAGAGAAATCCAAGCTGCAGGAGATCTACCAG
GAGCTGACCCGGCTGAAGGCTGCAGTGGGTGAGTTGCCAGAGAAATCCAAGCTGCAGGAG
ATCTACCAGGAGCTGACCCGGCTGAAGGCTGCAGTGGGTGAGTTGCCAGAGAAATCCAAG
CTGCAGGAGATCTACCAGGAGCTGACGGAGCTGAAGGCTGCAGTGGGTGAGTTGCCAGAG
AAATCCAAGCTGCAGGAGATCTACCAGGAGCTGACCCAGCTGAAGGCTGCAGTGGGTGAG
TTGCCAGACCAGTCCAAGCAGCAGCAAATCTATCAAGAACTGACCGATTTGAAGACTGCA
TTTGAACGCCTGTGCCGCCACTGTCCCAAGGACTGGACATTCTTCCAAGGAAACTGTTAC
TTCATGTCTAACTCCCAGCGGAACTGGCACGACTCCGTCACCGCCTGCCAGGAAGTGAGG
GCCCAGCTCGTCGTAATCAAAACTGCTGAGGAGCAGAACTTCCTACAGCTGCAGACTTCC
AGGAGTAACCGCTTCTCCTGGATGGGACTTTCAGACCTAAATCAGGAAGGCACGTGGCAA
TGGGTGGACGGCTCACCTCTGTCACCCAGCTTCCAGCGGTACTGGAACAGTGGAGAACCC
AACAATAGCGGGAATGAAGACTGTGCGGAATTTAGTGGCAGTGGCTGGAACGACAATCGA
TGTGACGTTGACAATTACTGGATCTGCAAAAAGCCCGCAGCCTGCTTCAGAGACGAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 399 |
| Molecular Weight
| 45349.9 |
| Theoretical pI
| 4.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>C-type lectin domain family 4 member M
MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFML
LAGVLVAILVQVSKVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLK
AAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQE
IYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVGE
LPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEVR
AQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEP
NNSGNEDCAEFSGSGWNDNRCDVDNYWICKKPAACFRDE
|
| External Links |
|---|
| GenBank ID Protein
| 42542390 |
| UniProtKB/Swiss-Prot ID
| Q9H2X3 |
| UniProtKB/Swiss-Prot Entry Name
| CLC4M_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_014257.4 |
| GeneCard ID
| CLEC4M |
| GenAtlas ID
| CLEC4M |
| HGNC ID
| HGNC:13523 |
| References |
|---|
| General References
| Not Available |