| Identification |
|---|
| HMDB Protein ID
| CDBP02158 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cadherin-15 |
| Description
| Not Available |
| Synonyms
|
- Cadherin-14
- M-cadherin
- Muscle cadherin
|
| Gene Name
| CDH15 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| metal ion binding |
| binding |
| calcium ion binding |
| ion binding |
| cation binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q24.3 |
| SNPs
| CDH15 |
| Gene Sequence
|
>2445 bp
ATGGACGCCGCGTTCCTCCTCGTCCTCGGGCTGTTGGCCCAGAGCCTCTGCCTGTCTTTG
GGGGTTCCTGGATGGAGGAGGCCCACCACCCTGTACCCCTGGCGCCGGGCGCCTGCCCTG
AGCCGCGTGCGGAGGGCCTGGGTCATCCCCCCGATCAGCGTATCCGAGAACCACAAGCGT
CTCCCCTACCCCCTGGTTCAGATCAAGTCGGACAAGCAGCAGCTGGGCAGCGTCATCTAC
AGCATCCAGGGACCCGGCGTGGATGAGGAGCCCCGGGGCGTCTTCTCTATCGACAAGTTC
ACAGGGAAGGTCTTCCTCAATGCCATGCTGGACCGCGAGAAGACTGATCGCTTCAGGCTA
AGAGCGTTTGCCCTGGACCTGGGAGGATCCACCCTGGAGGACCCCACGGACCTGGAGATT
GTAGTTGTGGATCAGAATGACAACCGGCCAGCCTTCCTGCAGGAGGCGTTCACTGGCCGC
GTGCTGGAGGGTGCAGTCCCAGGCACCTATGTGACCAGGGCAGAGGCCACAGATGCCGAC
GACCCCGAGACGGACAACGCAGCGCTGCGGTTCTCCATCCTGCAGCAGGGCAGCCCCGAG
CTCTTCAGCATCGACGAGCTCACAGGAGAGATCCGCACAGTGCAAGTGGGGCTGGACCGC
GAGGTGGTCGCGGTGTACAATCTGACCCTGCAGGTGGCGGACATGTCTGGAGACGGCCTC
ACAGCCACTGCCTCAGCCATCATCACCCTTGATGACATCAATGACAATGCCCCCGAGTTC
ACCAGGGATGAGTTCTTCATGGAGGCCATAGAGGCCGTCAGCGGAGTGGATGTGGGACGC
CTGGAAGTGGAGGACAGGGACCTGCCAGGCTCCCCAAACTGGGTGGCCAGGTTCACTATC
CTGGAAGGCGACCCCGATGGGCAGTTCACCATCCGCACGGACCCCAAGACCAACGAGGGT
GTTCTGTCCATTGTGAAGGCCCTGGACTATGAGAGCTGTGAACACTACGAACTCAAAGTG
TCGGTGCAGAATGAGGCCCCGCTGCAGGCGGCTGCCCTTAGGGCTGAGCGGGGCCAGGCC
AAGGTCCGCGTGCATGTGCAGGACACCAACGAGCCCCCCGTGTTCCAGGAGAACCCACTT
CGGACCAGCCTAGCAGAGGGGGCACCCCCAGGCACTCTGGTGGCCACCTTCTCTGCCCGG
GACCCTGACACAGAGCAGCTGCAGAGGCTCAGCTACTCCAAGGACTACGACCCGGAAGAC
TGGCTGCAAGTGGACGCAGCCACTGGCCGGATCCAGACCCAGCACGTGCTCAGCCCGGCG
TCCCCCTTCCTCAAGGGCGGCTGGTACAGAGCCATCGTCCTGGCCCAGGATGACGCCTCC
CAGCCCCGCACCGCCACCGGCACCCTGTCCATCGAGATCCTGGAGGTGAACGACCATGCA
CCTGTGCTGGCCCCGCCGCCGCCGGGCAGCCTGTGCAGCGAGCCACACCAAGGCCCAGGC
CTCCTCCTGGGCGCCACGGATGAGGACCTGCCCCCCCACGGGGCCCCCTTCCACTTCCAG
CTGAGCCCCAGGCTCCCAGAGCTCGGCCGGAACTGGAGCCTCAGCCAGGTCAACGTGAGC
CACGCGCGCCTGCGGCCGCGACACCAGGTCCCCGAAGGCCTGCACCGCCTCAGCCTGCTG
CTCCGGGACTCGGGGCAGCCGCCCCAGCAGCGCGAGCAGCCTCTGAACGTGACCGTGTGC
CGCTGCGGCAAGGACGGCGTCTGCCTGCCGGGGGCCGCAGCGCTGCTGGCGGGGGGCACA
GGCCTCAGCCTGGGCGCACTGGTCATCGTGCTGGCCAGCGCCCTCCTGCTGCTGGTGCTG
GTCCTGCTCGTGGCACTCCGGGCGCGGTTCTGGAAGCAGTCTCGGGGCAAGGGGCTGCTG
CACGGCCCCCAGGACGACCTTCGAGACAATGTCCTCAACTACGATGAGCAAGGAGGCGGG
GAGGAGGACCAGGACGCCTACGACATCAGCCAGCTGCGTCACCCGACAGCGCTGAGCCTG
CCTCTGGGACCGCCGCCACTTCGCAGAGATGCCCCGCAGGGCCGCCTGCACCCCCAGCCA
CCCCGAGTGCTGCCCACCAGCCCCCTGGACATCGCCGACTTCATCAATGATGGCTTGGAG
GCTGCAGATAGTGACCCCAGTGTGCCGCCTTACGACACAGCCCTCATCTATGACTACGAG
GGTGACGGCTCGGTGGCGGGGACGCTGAGCTCCATCCTGTCCAGCCAGGGCGATGAGGAC
CAGGACTACGACTACCTCAGAGACTGGGGGCCCCGCTTCGCCCGGCTGGCAGACATGTAT
GGGCACCCGTGCGGGTTGGAGTACGGGGCCAGATGGGACCACCAGGCCAGGGAGGGTCTT
TCTCCTGGGGCACTGCTACCCAGACACAGAGGCCGGACAGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 814 |
| Molecular Weight
| 88915.0 |
| Theoretical pI
| 4.58 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-15
MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKR
LPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRL
RAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDAD
DPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGL
TATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTI
LEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQA
KVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPED
WLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHA
PVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVS
HARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGT
GLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGG
EEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLE
AADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMY
GHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA
|
| External Links |
|---|
| GenBank ID Protein
| 14286300 |
| UniProtKB/Swiss-Prot ID
| P55291 |
| UniProtKB/Swiss-Prot Entry Name
| CAD15_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC008951 |
| GeneCard ID
| CDH15 |
| GenAtlas ID
| CDH15 |
| HGNC ID
| HGNC:1754 |
| References |
|---|
| General References
| Not Available |