Identification |
HMDB Protein ID
| CDBP02148 |
Secondary Accession Numbers
| Not Available |
Name
| Sodium/glucose cotransporter 1 |
Description
| Not Available |
Synonyms
|
- High affinity sodium-glucose cotransporter
- Na(+)/glucose cotransporter 1
- Solute carrier family 5 member 1
|
Gene Name
| SLC5A1 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in transporter activity |
Specific Function
| Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
|
GO Classification
|
Biological Process |
small molecule metabolic process |
intestinal absorption |
carbohydrate metabolic process |
Cellular Component |
cell-cell junction |
brush border membrane |
apical plasma membrane |
integral to plasma membrane |
Component |
membrane |
cell part |
Function |
transporter activity |
Molecular Function |
glucose:sodium symporter activity |
Process |
establishment of localization |
transport |
transmembrane transport |
|
Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Carbohydrate digestion and absorption | Not Available | | Bile secretion | Not Available | | Mineral absorption | Not Available | | Lactose Degradation | | Not Available | Lactose Intolerance | | Not Available |
|
Gene Properties |
Chromosome Location
| 22 |
Locus
| 22q12.3 |
SNPs
| SLC5A1 |
Gene Sequence
|
>1995 bp
ATGGACAGTAGCACCTGGAGCCCCAAGACCACCGCGGTCACCCGGCCTGTTGAGACCCAC
GAGCTCATTCGCAATGCAGCCGATATCTCCATCATCGTTATCTACTTCGTGGTAGTGATG
GCCGTCGGACTGTGGGCTATGTTTTCCACCAATCGTGGGACTGTTGGAGGCTTCTTCCTG
GCAGGCCGAAGTATGGTGTGGTGGCCGATTGGAGCCTCCCTCTTTGCTAGTAACATTGGA
AGTGGCCACTTTGTGGGGCTGGCCGGGACTGGGGCAGCTTCAGGCATCGCCATTGGAGGC
TTTGAATGGAATGCCCTGGTTTTGGTGGTTGTGCTGGGCTGGCTGTTTGTCCCCATCTAT
ATTAAGGCTGGGGTGGTGACAATGCCAGAGTACCTGAGGAAGCGGTTTGGAGGCCAGCGG
ATCCAGGTCTACCTTTCCCTTCTGTCCCTGCTGCTCTACATTTTCACCAAGATCTCGGCA
GACATCTTCTCGGGGGCCATATTCATCAATCTGGCCTTAGGCCTGAATCTGTATTTAGCC
ATCTTTCTCTTATTGGCAATCACTGCCCTTTACACAATTACAGGGGGCCTGGCGGCGGTG
ATTTACACGGACACCTTGCAGACGGTGATCATGCTGGTGGGGTCTTTAATCCTGACTGGG
TTTGCTTTTCACGAAGTGGGAGGCTATGACGCCTTCATGGAAAAGTACATGAAAGCCATT
CCAACCATAGTGTCTGATGGCAACACCACCTTTCAGGAAAAATGCTACACTCCAAGGGCC
GACTCCTTCCACATCTTCCGAGATCCCCTCACGGGAGACCTCCCATGGCCTGGGTTCATC
TTTGGGATGTCCATCCTTACCTTGTGGTACTGGTGCACAGATCAGGTCATTGTGCAGCGC
TGCCTCTCAGCCAAGAATATGTCTCACGTGAAGGGTGGCTGCATCCTGTGTGGGTATCTA
AAGCTGATGCCCATGTTCATCATGGTGATGCCAGGAATGATCAGCCGCATTCTGTACACA
GAAAAAATTGCCTGTGTCGTCCCTTCAGAATGTGAGAAATATTGCGGTACCAAGGTTGGC
TGTACCAACATCGCCTATCCAACCTTAGTGGTGGAGCTCATGCCCAATGGACTGCGAGGC
CTGATGCTATCAGTCATGCTGGCCTCCCTCATGAGCTCCCTGACCTCCATCTTCAACAGC
GCCAGCACCCTCTTCACCATGGACATCTACGCCAAGGTCCGCAAGAGAGCATCTGAGAAA
GAGCTCATGATTGCCGGAAGGTTGTTTATCCTGGTGCTGATTGGCATCAGCATCGCCTGG
GTGCCCATTGTGCAGTCAGCACAAAGTGGGCAACTCTTCGATTACATCCAGTCCATCACC
AGTTACTTGGGACCACCCATTGCGGCTGTCTTCCTGCTTGCTATTTTCTGGAAGAGAGTC
AATGAGCCAGGAGCCTTTTGGGGACTGATCCTAGGACTTCTGATTGGGATTTCACGTATG
ATTACTGAGTTTGCTTATGGAACCGGGAGCTGCATGGAGCCCAGCAACTGTCCCACGATT
ATCTGTGGGGTGCACTACTTGTACTTTGCCATTATCCTCTTCGCCATTTCTTTCATCACC
ATCGTGGTCATCTCCCTCCTCACCAAACCCATTCCGGATGTGCATCTCTACCGTCTGTGT
TGGAGCCTGCGCAACAGCAAAGAGGAGCGTATTGACCTGGATGCGGAAGAGGAGAACATC
CAAGAAGGCCCTAAGGAGACCATTGAAATAGAAACACAAGTTCCTGAGAAGAAAAAAGGA
ATCTTCAGGAGAGCCTATGACCTATTTTGTGGGCTAGAGCAGCACGGTGCACCCAAGATG
ACTGAGGAAGAGGAGAAAGCCATGAAGATGAAGATGACGGACACCTCTGAGAAGCCTTTG
TGGAGGACAGTGTTGAACGTCAATGGCATCATCCTGGTGACCGTGGCTGTCTTTTGCCAT
GCATATTTTGCCTGA
|
Protein Properties |
Number of Residues
| 664 |
Molecular Weight
| 73497.275 |
Theoretical pI
| 7.685 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Sodium/glucose cotransporter 1
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
|
External Links |
GenBank ID Protein
| 189066539 |
UniProtKB/Swiss-Prot ID
| P13866 |
UniProtKB/Swiss-Prot Entry Name
| SC5A1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK312948 |
GeneCard ID
| SLC5A1 |
GenAtlas ID
| SLC5A1 |
HGNC ID
| HGNC:11036 |
References |
General References
| Not Available |