| Identification |
|---|
| HMDB Protein ID
| CDBP02146 |
| Secondary Accession Numbers
| Not Available |
| Name
| Zinc finger protein 148 |
| Description
| Not Available |
| Synonyms
|
- Transcription factor ZBP-89
- Zinc finger DNA-binding protein 89
|
| Gene Name
| ZNF148 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| nucleic acid binding |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q21 |
| SNPs
| ZNF148 |
| Gene Sequence
|
>2385 bp
ATGAACATTGACGACAAACTGGAAGGATTGTTTCTTAAATGTGGCGGCATAGACGAAATG
CAGTCTTCCAGGACAATGGTTGTAATGGGTGGAGTGTCTGGCCAGTCTACTGTGTCTGGA
GAGCTACAGGATTCAGTACTTCAAGATCGAAGTATGCCTCACCAGGAGATCCTTGCTGCA
GATGAAGTGTTACAAGAAAGTGAAATGAGACAACAGGATATGATATCACATGATGAACTC
ATGGTCCATGAGGAGACAGTGAAAAATGATGAAGAGCAGATGGAAACACATGAAAGACTT
CCTCAAGGACTACAGTATGCACTTAATGTCCCTATAAGCGTAAAGCAGGAAATTACTTTT
ACTGATGTATCTGAGCAACTGATGAGAGACAAAAAACAAATCAGAGAGCCAGTAGACTTA
CAGAAAAAGAAGAAGCGGAAACAACGTTCTCCCGCAAAAATCCTTACAATAAATGAGGAT
GGATCACTTGGTTTGAAAACCCCTAAATCTCACGTTTGTGAGCACTGCAATGCTGCCTTT
AGAACGAACTATCACTTACAGAGACATGTCTTCATTCATACAGGTGAAAAACCATTTCAA
TGTAGTCAATGTGACATGCGTTTCATACAGAAGTACCTGCTTCAGAGACATGAGAAGATT
CATACTGGTGAAAAACCATTTCGCTGTGATGAATGTGGTATGAGATTCATACAAAAATAT
CATATGGAAAGGCATAAGAGAACTCATAGTGGAGAAAAACCTTACCAGTGTGAATACTGT
TTACAGTATTTTTCCAGAACAGATCGTGTATTGAAACATAAACGTATGTGCCATGAAAAT
CATGACAAAAAACTAAATAGATGTGCCATCAAAGGTGGCCTTCTGACATCTGAGGAAGAT
TCTGGCTTTTCTACATCACCAAAAGACAACTCACTGCCAAAAAAGAAAAGGCAGAAAACG
GAGAAAAAATCATCTGGAATGGACAAAGAGAGTGCTTTGGACAAATCTGACCTGAAAAAA
GACAAAAATGATTACTTGCCTCTTTATTCTTCAAGTACTAAAGTAAAAGATGAGTATATG
GTTGCAGAATATGCTGTTGAAATGCCACATTCGTCAGTTGGGGGCTCGCATTTAGAAGAT
GCGTCAGGAGAAATACACCCACCTAAGTTAGTTCTCAAAAAAATTAATAGTAAGAGAAGT
CTGAAACAGCCACTGGAGCAAAATCAAACAATTTCACCTTTATCCACATATGAAGAGAGC
AAAGTTTCAAAGTATGCTTTTGAACTTGTGGATAAACAGGCTTTACTGGACTCAGAAGGC
AATGCTGACATTGATCAGGTTGATAATTTGCAGGAGGGGCCCAGTAAACCTGTGCATAGT
AGTACTAATTATGATGATGCCATGCAGTTTTTGAAGAAGAAGCGGTATCTTCAAGCAGCA
AGTAACAACAGCAGGGAATATGCGCTGAATGTGGGTACCATAGCTTCTCAGCCTTCTGTA
ACACAAGCAGCTGTGGCAAGTGTCATTGATGAAAGTACCACGGCATCCATATTAGAGTCA
CAGGCACTGAATGTGGAGATTAAGAGTAATCATGACAAAAATGTTATTCCAGATGAGGTA
CTGCAGACTCTGTTGGATCATTATTCCCACAAAGCTAATGGACAGCATGAGATATCCTTC
AGTGTTGCAGATACTGAAGTGACTTCTAGCATATCAATAAATTCTTCAGAAGTACCAGAG
GTCACCCCGTCAGAGAATGTTGGATCAAGCTCCCAAGCATCCTCATCAGATAAAGCCAAC
ATGTTGCAGGAATACTCCAAGTTTCTGCAGCAGGCTTTGGACAGAACTAGCCAAAATGAT
GCCTATTTGAATAGCCCGAGCCTTAACTTTGTGACTGATAACCAGACCCTCCCAAATCAG
CCAGCATTCTCTTCCATAGACAAGCAGGTCTATGCCACCATGCCCATCAATAGCTTTCGA
TCAGGAATGAATTCTCCACTAAGAACAACTCCAGATAAGTCCCACTTTGGACTAATAGTT
GGTGATTCACAGCACTCATTTCCCTTTTCAGGTGATGAGACAAACCATGCTTCTGCCACA
TCAACACAGGACTTTCTGGATCAAGTGACTTCTCAGAAGAAAGCTGAGGCCCAGCCTGTC
CACCAAGCTTACCAAATGAGCTCCTTTGAACAGCCCTTCCGTGCTCCCTATCATGGATCA
AGAGCTGGAATAGCTACTCAATTTAGCACTGCCAATGGACAGGTGAACCTTCGGGGACCA
GGGACAAGTGCTGAATTTTCAGAATTTCCCTTGGTGAATGTAAATGATAATAGAGCTGGG
ATGACATCTTCACCTGATGCCACAACTGGCCAGACTTTTGGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 794 |
| Molecular Weight
| 88975.6 |
| Theoretical pI
| 6.46 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Zinc finger protein 148
MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQDSVLQDRSMPHQEILAA
DEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITF
TDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAF
RTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKY
HMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEED
SGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLKKDKNDYLPLYSSSTKVKDEYM
VAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEES
KVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAA
SNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILESQALNVEIKSNHDKNVIPDEV
LQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTPSENVGSSSQASSSDKAN
MLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFR
SGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPV
HQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAG
MTSSPDATTGQTFG
|
| External Links |
|---|
| GenBank ID Protein
| 2828110 |
| UniProtKB/Swiss-Prot ID
| Q9UQR1 |
| UniProtKB/Swiss-Prot Entry Name
| ZN148_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF039019 |
| GeneCard ID
| ZNF148 |
| GenAtlas ID
| ZNF148 |
| HGNC ID
| HGNC:12933 |
| References |
|---|
| General References
| Not Available |