Showing Protein Pterin-4-alpha-carbinolamine dehydratase (CDBP02133)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP02133
Secondary Accession Numbers Not Available
Name Pterin-4-alpha-carbinolamine dehydratase
Description Not Available
Synonyms
  1. 4-alpha-hydroxy-tetrahydropterin dehydratase
  2. DCoH
  3. Dimerization cofactor of HNF1
  4. Dimerization cofactor of hepatocyte nuclear factor 1-alpha
  5. PCD
  6. PHS
  7. Phenylalanine hydroxylase-stimulating protein
  8. Pterin carbinolamine dehydratase
Gene Name PCBD1
Protein Type Enzyme
Biological Properties
General Function Involved in 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
Specific Function Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.
GO Classification
Biological Process
cellular nitrogen compound metabolic process
protein heterooligomerization
protein homotetramerization
regulation of transcription, DNA-dependent
transcription, DNA-dependent
tetrahydrobiopterin biosynthetic process
L-phenylalanine catabolic process
Cellular Component
cytosol
nucleus
Function
catalytic activity
lyase activity
4-alpha-hydroxytetrahydrobiopterin dehydratase activity
carbon-oxygen lyase activity
hydro-lyase activity
Molecular Function
phenylalanine 4-monooxygenase activity
4-alpha-hydroxytetrahydrobiopterin dehydratase activity
transcription coactivator activity
Process
metabolic process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
pteridine and derivative biosynthetic process
tetrahydrobiopterin biosynthetic process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 10
Locus 10q22
SNPs PCBD1
Gene Sequence 
>315 bp
ATGGCTGGCAAAGCACACAGGCTGAGCGCTGAGGAGAGGGACCAGCTGCTGCCAAACCTG
AGGGCTGTGGGGTGGAATGAGCTGGAAGGCCGTGATGCCATCTTCAAGCAGTTTCATTTC
AAAGACTTCAACAGGGCCTTTGGGTTCATGACAAGAGTGGCCCTGCAGGCTGAGAAACTG
GACCACCATCCTGAATGGTTTAACGTGTACAACAAGGTCCACATCACGCTGAGCACCCAT
GAGTGTGCCGGCCTTTCAGAACGGGACATAAACCTGGCCAGCTTCATCGAACAAGTAGCA
GTGTCCATGACATAG
Protein Properties
Number of Residues 104
Molecular Weight 11999.515
Theoretical pI 6.793
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Pterin-4-alpha-carbinolamine dehydratase
MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKL
DHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT
GenBank ID Protein 4587464
UniProtKB/Swiss-Prot ID P61457
UniProtKB/Swiss-Prot Entry Name PHS_HUMAN
PDB IDs Not Available
GenBank Gene ID AF082858
GeneCard ID PCBD1
GenAtlas ID PCBD1
HGNC ID HGNC:8646
References
General References Not Available