| Identification |
|---|
| HMDB Protein ID
| CDBP02133 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pterin-4-alpha-carbinolamine dehydratase |
| Description
| Not Available |
| Synonyms
|
- 4-alpha-hydroxy-tetrahydropterin dehydratase
- DCoH
- Dimerization cofactor of HNF1
- Dimerization cofactor of hepatocyte nuclear factor 1-alpha
- PCD
- PHS
- Phenylalanine hydroxylase-stimulating protein
- Pterin carbinolamine dehydratase
|
| Gene Name
| PCBD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| Specific Function
| Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.
|
| GO Classification
|
| Biological Process |
| cellular nitrogen compound metabolic process |
| protein heterooligomerization |
| protein homotetramerization |
| regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| tetrahydrobiopterin biosynthetic process |
| L-phenylalanine catabolic process |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| catalytic activity |
| lyase activity |
| 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| carbon-oxygen lyase activity |
| hydro-lyase activity |
| Molecular Function |
| 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| transcription coactivator activity |
| phenylalanine 4-monooxygenase activity |
| Process |
| metabolic process |
| biosynthetic process |
| cellular biosynthetic process |
| heterocycle biosynthetic process |
| pteridine and derivative biosynthetic process |
| tetrahydrobiopterin biosynthetic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q22 |
| SNPs
| PCBD1 |
| Gene Sequence
|
>315 bp
ATGGCTGGCAAAGCACACAGGCTGAGCGCTGAGGAGAGGGACCAGCTGCTGCCAAACCTG
AGGGCTGTGGGGTGGAATGAGCTGGAAGGCCGTGATGCCATCTTCAAGCAGTTTCATTTC
AAAGACTTCAACAGGGCCTTTGGGTTCATGACAAGAGTGGCCCTGCAGGCTGAGAAACTG
GACCACCATCCTGAATGGTTTAACGTGTACAACAAGGTCCACATCACGCTGAGCACCCAT
GAGTGTGCCGGCCTTTCAGAACGGGACATAAACCTGGCCAGCTTCATCGAACAAGTAGCA
GTGTCCATGACATAG
|
| Protein Properties |
|---|
| Number of Residues
| 104 |
| Molecular Weight
| 11999.515 |
| Theoretical pI
| 6.793 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pterin-4-alpha-carbinolamine dehydratase
MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKL
DHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT
|
| External Links |
|---|
| GenBank ID Protein
| 4587464 |
| UniProtKB/Swiss-Prot ID
| P61457 |
| UniProtKB/Swiss-Prot Entry Name
| PHS_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF082858 |
| GeneCard ID
| PCBD1 |
| GenAtlas ID
| PCBD1 |
| HGNC ID
| HGNC:8646 |
| References |
|---|
| General References
| Not Available |