| Identification |
|---|
| HMDB Protein ID
| CDBP02121 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA-3-methyladenine glycosylase |
| Description
| Not Available |
| Synonyms
|
- 3-alkyladenine DNA glycosylase
- 3-methyladenine DNA glycosidase
- ADPG
- N-methylpurine-DNA glycosylase
|
| Gene Name
| MPG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions |
| GO Classification
|
| Function |
| hydrolase activity, hydrolyzing n-glycosyl compounds |
| alkylbase dna n-glycosylase activity |
| nucleic acid binding |
| dna binding |
| dna n-glycosylase activity |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| Process |
| base-excision repair |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| dna metabolic process |
| dna repair |
|
| Cellular Location
|
- Nucleus (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p13.3 |
| SNPs
| MPG |
| Gene Sequence
|
>897 bp
ATGGTCACCCCCGCTTTGCAGATGAAGAAACCAAAGCAGTTTTGCCGACGGATGGGGCAA
AAGAAGCAGCGACCAGCTAGAGCAGGGCAGCCACACAGCTCGTCCGACGCAGCCCAGGCA
CCTGCAGAGCAGCCACACAGCTCGTCCGATGCAGCCCAGGCACCTTGCCCCAGGGAGCGC
TGCTTGGGACCGCCCACCACTCCGGGCCCATACCGCAGCATCTATTTCTCAAGCCCAAAG
GGCCACCTTACCCGACTGGGGTTGGAGTTCTTCGACCAGCCGGCAGTCCCCCTGGCCCGG
GCATTTCTGGGACAGGTCCTAGTCCGGCGACTTCCTAATGGCACAGAACTCCGAGGCCGC
ATCGTGGAGACCGAGGCATACCTGGGGCCAGAGGATGAAGCCGCCCACTCAAGGGGTGGC
CGGCAGACCCCCCGCAACCGAGGCATGTTCATGAAGCCGGGGACCCTGTACGTGTACATC
ATTTACGGCATGTACTTCTGCATGAACATCTCCAGCCAGGGGGACGGGGCTTGCGTCTTG
CTGCGAGCACTGGAGCCCCTGGAAGGTCTGGAGACCATGCGTCAGCTTCGCAGCACCCTC
CGGAAAGGCACCGCCAGCCGTGTCCTCAAGGACCGCGAGCTCTGCAGTGGCCCCTCCAAG
CTGTGCCAGGCCCTGGCCATCAACAAGAGCTTTGACCAGAGGGACCTGGCACAGGATGAA
GCTGTATGGCTGGAGCGTGGTCCCCTGGAGCCCAGTGAGCCGGCTGTAGTGGCAGCAGCC
CGGGTGGGCGTCGGCCATGCAGGGGAGTGGGCCCGGAAACCCCTCCGCTTCTATGTCCGG
GGCAGCCCCTGGGTCAGTGTGGTCGACAGAGTGGCTGAGCAGGACACACAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 298 |
| Molecular Weight
| 32868.4 |
| Theoretical pI
| 10.0 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>DNA-3-methyladenine glycosylase
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRER
CLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGR
IVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVL
LRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDE
AVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
|
| External Links |
|---|
| GenBank ID Protein
| 62632769 |
| UniProtKB/Swiss-Prot ID
| P29372 |
| UniProtKB/Swiss-Prot Entry Name
| 3MG_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_002434.2 |
| GeneCard ID
| MPG |
| GenAtlas ID
| MPG |
| HGNC ID
| HGNC:7211 |
| References |
|---|
| General References
| Not Available |