| Identification |
|---|
| HMDB Protein ID
| CDBP02119 |
| Secondary Accession Numbers
| Not Available |
| Name
| Oxysterol-binding protein 1 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| OSBP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in steroid metabolic process |
| Specific Function
| Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability |
| GO Classification
|
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
| steroid metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Golgi apparatus membrane
- Peripheral membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q12-q13 |
| SNPs
| OSBP |
| Gene Sequence
|
>2424 bp
ATGGCGGCGACGGAGCTGAGAGGAGTGGTGGGGCCAGGCCCGGCAGCCATTGCAGCACTT
GGCGGCGGCGGCGCCGGTCCCCCAGTGGTGGGAGGAGGCGGCGGCCGCGGAGATGCGGGG
CCAGGCTCCGGGGCCGCGTCAGGGACGGTGGTCGCGGCGGCGGCGGGAGGCCCGGGCCCG
GGGGCCGGGGGAGTGGCGGCGGCTGGCCCGGCCCCTGCGCCGCCGACTGGGGGCTCGGGC
GGCTCGGGCGCTGGGGGTTCGGGCTCGGCTCGAGAGGGCTGGCTCTTCAAATGGACCAAT
TATATCAAAGGCTACCAGCGGCGATGGTTCGTGCTGAGCAACGGGCTCCTGAGCTACTAC
AGATCAAAGGCAGAAATGAGACATACCTGCCGTGGTACCATCAACCTCGCCACAGCCAAC
ATCACCGTGGAGGACTCCTGCAACTTCATCATTTCCAATGGGGGTGCTCAGACCTACCAT
CTGAAAGCTAGTTCAGAAGTTGAGCGGCAGCGCTGGGTGACGGCCCTGGAACTGGCCAAG
GCCAAAGCTGTGAAGATGCTGGCAGAGTCAGATGAATCAGGAGATGAAGAGTCTGTCTCA
CAAACTGACAAGACTGAGCTGCAGAATACCCTTCGGACCCTCTCTAGCAAAGTAGAGGAC
TTGAGCACGTGCAATGACTTGATAGCTAAGCATGGCACAGCTCTGCAGCGTTCTCTCAGT
GAGCTGGAGTCCCTGAAGTTGCCTGCTGAGAGCAATGAAAAGATCAAACAGGTCAACGAA
CGAGCCACACTCTTTAGGATAACATCCAATGCCATGATCAACGCCTGCAGAGATTTCCTC
ATGTTAGCCCAGACCCATAGTAAAAAATGGCAAAAGTCACTACAGTATGAAAGAGACCAG
CGTATCCGACTGGAAGAAACCCTCGAGCAGCTGGCGAAGCAGCATAATCACCTGGAGAGG
GCCTTCCGAGGAGCCACGGTGCTGCCGGCAAACACTCCTGGCAATGTGGGTTCTGGTAAA
GATCAGTGCTGCTCTGGCAAAGGGGACATGAGCGATGAAGATGATGAGAATGAATTTTTT
GATGCACCTGAGATCATCACCATGCCTGAAAATTTGGGCCACAAACGTACTGGCAGCAAT
ATCAGTGGAGCCAGCAGTGACATCAGCCTTGATGAACAGTACAAGCATCAGCTGGAGGAG
ACCAAAAAGGAAAAGAGAACCAGAATACCATACAAGCCAAACTATAGCCTCAATTTATGG
AGCATCATGAAGAACTGCATTGGAAAAGAACTCTCTAAGATCCCCATGCCGGTAAACTTT
AATGAGCCCTTGTCCATGCTTCAGCGCCTTACTGAAGATCTGGAATACCATGAGCTGTTA
GACCGAGCTGCAAAATGTGAGAATTCTCTAGAACAGCTCTGTTATGTTGCAGCTTTCACC
GTGTCCTCCTACTCCACTACTGTCTTCCGCACCAGTAAGCCATTCAACCCACTGCTTGGG
GAGACCTTTGAGCTGGACCGATTAGAGGAGAATGGGTACCGATCCCTCTGTGAACAGGTG
AGTCATCATCCCCCTGCTGCTGCGCACCATGCTGAGTCCAAAAATGGCTGGACATTGCGT
CAGGAAATCAAAATCACCAGCAAGTTTCGAGGCAAATACCTCTCCATTATGCCCCTCGGT
ACCATTCATTGTATTTTCCATGCAACTGGGCACCACTACACTTGGAAGAAAGTTACCACA
ACTGTACACAACATTATTGTGGGCAAGTTGTGGATAGATCAGTCTGGCGAAATTGATATT
GTGAATCACAAGACAGGAGACAAGTGTAATCTTAAATTTGTTCCTTATAGCTACTTCTCT
CGGGATGTAGCAAGAAAGGTGACGGGGGAAGTGACAGATCCATCAGGAAAAGTCCACTTT
GCTCTTCTGGGGACGTGGGATGAGAAAATGGAATGTTTCAAAGTACAGCCAGTCATTGGG
GAAAATGGGGGTGATGCTCGACAGAGAGGCCATGAAGCAGAGGAAAGCAGGGTCATGCTG
TGGAAAAGGAATCCTTTACCGAAGAATGCAGAAAACATGTACTACTTCTCAGAGCTTGCT
CTGACTCTCAATGCTTGGGAAAGTGGCACTGCCCCCACAGACAGCCGGTTACGACCTGAC
CAGAGACTGATGGAAAATGGACGCTGGGATGAAGCAAATGCGGAGAAGCAGCGCCTGGAG
GAAAAACAAAGACTTTCCAGAAAGAAGAGAGAAGCGGAAGCTATGAAAGCCACAGAGGAT
GGCACACCATATGATCCCTATAAGGCACTGTGGTTTGAGCGGAAGAAGGACCCTGTTACC
AAGGAGTTAACCCATATTTATAGGGGAGAATACTGGGAGTGTAAAGAAAAACAGGACTGG
AGCTCATGCCCGGACATTTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 807 |
| Molecular Weight
| 89419.9 |
| Theoretical pI
| 7.31 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Oxysterol-binding protein 1
MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGP
GAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYY
RSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAK
AKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLS
ELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQ
RIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFF
DAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLW
SIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFT
VSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLR
QEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDI
VNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIG
ENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPD
QRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVT
KELTHIYRGEYWECKEKQDWSSCPDIF
|
| External Links |
|---|
| GenBank ID Protein
| 10441380 |
| UniProtKB/Swiss-Prot ID
| P22059 |
| UniProtKB/Swiss-Prot Entry Name
| OSBP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF185696 |
| GeneCard ID
| OSBP |
| GenAtlas ID
| OSBP |
| HGNC ID
| HGNC:8503 |
| References |
|---|
| General References
| Not Available |