| Identification |
|---|
| HMDB Protein ID
| CDBP02091 |
| Secondary Accession Numbers
| Not Available |
| Name
| Caldesmon |
| Description
| Not Available |
| Synonyms
|
- CDM
|
| Gene Name
| CALD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in actin binding |
| Specific Function
| Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping |
| GO Classification
|
| Function |
| myosin binding |
| calmodulin binding |
| protein binding |
| cytoskeletal protein binding |
| actin binding |
| binding |
| Process |
| multicellular organismal process |
| system process |
| muscle system process |
| muscle contraction |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm
- cytoskeleton
- myofibril
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q33 |
| SNPs
| CALD1 |
| Gene Sequence
|
>2382 bp
ATGGATGATTTTGAGCGTCGCAGAGAACTTAGAAGGCAAAAGAGGGAGGAGATGCGACTC
GAAGCAGAAAGAATCGCCTACCAGAGGAATGACGATGATGAAGAGGAGGCAGCCCGGGAA
CGGCGCCGCCGAGCCCGACAGGAACGGCTGCGGCAGAAGCAGGAGGAAGAATCCTTGGGA
CAGGTGACCGACCAGGTGGAGGTGAATGCCCAGAACAGTGTGCCTGACGAGGAGGCCAAG
ACAACCACCACAAACACTCAAGTGGAAGGGGATGATGAGGCCGCATTCCTGGAGCGCCTG
GCTCGGCGTGAGGAAAGACGCCAAAAACGCCTTCAGGAGGCTCTGGAGCGGCAGAAGGAG
TTCGACCCAACAATAACAGATGCAAGTCTGTCGCTCCCAAGCAGAAGAATGCAAAATGAC
ACAGCAGAAAATGAAACTACCGAGAAGGAAGAAAAAAGTGAAAGTCGCCAAGAAAGATAC
GAGATAGAGGAAACAGAAACAGTCACCAAGTCCTACCAGAAGAATGATTGGAGGGATGCT
GAAGAAAACAAGAAAGAAGACAAGGAAAAGGAGGAGGAGGAAGAGGAGAAGCCAAAGCGA
GGGAGCATTGGAGAAAATCAGGTAGAGGTGATGGTGGAAGAGAAAACAACTGAAAGCCAG
GAGGAAACAGTGGTAATGTCATTAAAAAATGGGCAGATCAGTTCAGAAGAGCCTAAACAA
GAGGAGGAGAGGGAACAAGGTTCAGATGAGATTTCCCATCATGAAAAGATGGAAGAGGAA
GACAAGGAAAGAGCTGAGGCAGAGAGGGCAAGGTTGGAAGCAGAAGAAAGAGAAAGAATT
AAAGCCGAGCAAGACAAAAAGATAGCAGATGAACGAGCAAGAATTGAAGCAGAAGAAAAA
GCAGCTGCCCAAGAAAGAGAAAGGAGAGAGGCAGAAGAGAGGGAAAGGATGAGGGAGGAA
GAGAAAAGGGCAGCAGAGGAGAGGCAGAGGATAAAGGAGGAAGAGAAAAGGGCAGCAGAG
GAGAGGCAGAGGATAAAGGAGGAAGAGAAAAGGGCAGCAGAGGAGAGGCAGAGGATAAAA
GAGGAAGAGAAAAGGGCAGCAGAGGAGAGGCAAAGGGCCAGGGCAGAGGAGGAAGAGAAG
GCTAAGGTAGAAGAGCAGAAACGTAACAAGCAGCTAGAAGAGAAAAAACATGCCATGCAA
GAGACAAAGATAAAAGGGGAAAAGGTAGAACAGAAAATAGAAGGGAAATGGGTAAATGAA
AAGAAAGCACAAGAAGATAAACTTCAGACAGCTGTCCTAAAGAAACAGGGAGAAGAGAAG
GGAACTAAAGTGCAAGCTAAAAGAGAAAAGCTCCAAGAAGACAAGCCTACCTTCAAAAAA
GAAGAGATCAAAGATGAAAAGATTAAAAAGGACAAAGAACCCAAAGAAGAAGTTAAGAGC
TTCATGGATCGAAAGAAGGGATTTACAGAAGTTAAGTCGCAGAATGGAGAATTCATGACC
CACAAACTTAAACATACTGAGAATACTTTCAGCCGCCCTGGAGGGAGGGCCAGCGTGGAC
ACCAAGGAGGCTGAGGGCGCCCCCCAGGTGGAAGCCGGCAAAAGGCTGGAGGAGCTTCGT
CGTCGTCGCGGGGAGACCGAGAGCGAAGAGTTCGAGAAGCTCAAACAGAAGCAGCAGGAG
GCGGCTTTGGAGCTGGAGGAACTCAAGAAAAAGAGGGAGGAGAGAAGGAAGGTCCTGGAG
GAGGAAGAGCAGAGGAGGAAGCAGGAGGAAGCCGATCGAAAACTCAGAGAGGAGGAAGAG
AAGAGGAGGCTAAAGGAAGAGATTGAAAGGCGAAGAGCAGAAGCTGCTGAGAAACGCCAG
AAGATGCCAGAAGATGGCTTGTCAGATGACAAGAAACCATTCAAGTGTTTCACTCCTAAA
GGTTCATCTCTCAAGATAGAAGAGCGAGCAGAATTTTTGAATAAGTCTGTGCAGAAAAGC
AGTGGTGTCAAATCGACCCATCAAGCAGCAATAGTCTCCAAGATTGACAGCAGACTGGAG
CAGTATACCAGTGCAATTGAGGGAACAAAAAGCGCAAAACCTACAAAGCCGGCAGCCTCG
GATCTTCCTGTTCCTGCTGAAGGTGTACGCAACATCAAGAGTATGTGGGAGAAAGGGAAT
GTGTTTTCATCCCCCACTGCAGCAGGCACACCAAATAAGGAAACTGCTGGCTTGAAGGTA
GGGGTTTCTAGCCGCATCAATGAATGGCTAACTAAAACCCCAGATGGAAACAAGTCACCT
GCTCCCAAACCTTCTGACTTGAGACCAGGAGACGTATCCAGCAAGCGGAACCTCTGGGAA
AAGCAATCTGTGGATAAGGTCACTTCCCCCACTAAGGTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 793 |
| Molecular Weight
| 93249.5 |
| Theoretical pI
| 5.35 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Caldesmon
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ
EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK
AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK
EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKRAMQETKIKGEKVEQKIEGKWVNE
KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS
FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR
RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE
KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS
SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN
VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE
KQSVDKVTSPTKV
|
| External Links |
|---|
| GenBank ID Protein
| 44680105 |
| UniProtKB/Swiss-Prot ID
| Q05682 |
| UniProtKB/Swiss-Prot Entry Name
| CALD1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_033138.3 |
| GeneCard ID
| CALD1 |
| GenAtlas ID
| CALD1 |
| HGNC ID
| HGNC:1441 |
| References |
|---|
| General References
| Not Available |