Showing Protein Platelet basic protein (CDBP02088)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP02088
Secondary Accession Numbers Not Available
Name Platelet basic protein
Description Not Available
Synonyms
  1. Beta-TG
  2. Beta-thromboglobulin
  3. C-X-C motif chemokine 7
  4. CTAP-III
  5. CTAP-III(1-81)
  6. Connective tissue-activating peptide III
  7. Connective tissue-activating peptide III(1-81)
  8. LA-PF4
  9. LDGF
  10. Leukocyte-derived growth factor
  11. Low-affinity platelet factor IV
  12. MDGF
  13. Macrophage-derived growth factor
  14. NAP-2
  15. NAP-2(1-63)
  16. NAP-2(1-66)
  17. NAP-2(73)
  18. NAP-2(74)
  19. Neutrophil-activating peptide 2
  20. Neutrophil-activating peptide 2(1-63)
  21. Neutrophil-activating peptide 2(1-66)
  22. Neutrophil-activating peptide 2(73)
  23. Neutrophil-activating peptide 2(74)
  24. PBP
  25. Small-inducible cytokine B7
  26. TC-1
  27. TC-2
Gene Name PPBP
Protein Type Receptor
Biological Properties
General Function Involved in cytokine activity
Specific Function LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation
GO Classification
Component
extracellular region
Function
binding
protein binding
receptor binding
cytokine activity
chemokine activity
Process
immune system process
immune response
Cellular Location
  1. Secreted
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q12-q13
SNPs PPBP
Gene Sequence 
>387 bp
ATGAGCCTCAGACTTGATACCACCCCTTCCTGTAACAGTGCGAGACCACTTCATGCCTTG
CAGGTGCTGCTGCTTCTGTCATTGCTGCTGACTGCTCTGGCTTCCTCCACCAAAGGACAA
ACTAAGAGAAACTTGGCGAAAGGCAAAGAGGAAAGTCTAGACAGTGACTTGTATGCTGAA
CTCCGCTGCATGTGTATAAAGACAACCTCTGGAATTCATCCCAAAAACATCCAAAGTTTG
GAAGTGATCGGGAAAGGAACCCATTGCAACCAAGTCGAAGTGATAGCCACACTGAAGGAT
GGGAGGAAAATCTGCCTGGACCCAGATGCTCCCAGAATCAAGAAAATTGTACAGAAAAAA
TTGGCAGGTGATGAATCTGCTGATTAA
Protein Properties
Number of Residues 128
Molecular Weight 13894.0
Theoretical pI 9.07
Pfam Domain Function
Signals
  • ["1-34"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Platelet basic protein
MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAE
LRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKK
LAGDESAD
GenBank ID Protein 181176
UniProtKB/Swiss-Prot ID P02775
UniProtKB/Swiss-Prot Entry Name CXCL7_HUMAN
PDB IDs
GenBank Gene ID M54995
GeneCard ID PPBP
GenAtlas ID PPBP
HGNC ID HGNC:9240
References
General References Not Available